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In the current study we isolated from an intra\u2010cerebral brain\u2010site\u2010specific (AD temporal lobe vs. AD occipital lobe) polymerase chain reaction (PCR)\u2010select cDNA suppression subtractive hybridization (PCR\u2010cDNA\u2010SSH) expression analysis the novel gene P9TLDR, potentially a microtubule\u2010associated protein involved in neuronal migration, with an altered expression pattern: down\u2010regulated in the temporal lobe cortex of early stage AD brains. In an in vitro AD\u2010related cell model, amyloid\u2010\u03b2 peptide (A\u03b2)\u2010treated neurons, reduced P9TLDR expression correlated with increased tau protein phosphorylation. In conclusion, interference with the P9TLDR signalling pathways might be a therapeutic strategy for the treatment of AD.<\/jats:p>","DOI":"10.1016\/j.febslet.2012.10.050","type":"journal-article","created":{"date-parts":[[2012,11,15]],"date-time":"2012-11-15T10:31:02Z","timestamp":1352975462000},"page":"4357-4361","source":"Crossref","is-referenced-by-count":2,"title":["Characterization of the novel protein P9TLDR (temporal lobe down\u2010regulated) with a brain\u2010site\u2010specific gene expression modality in Alzheimer's disease 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