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Previous studies performed on Mecp2\u2010deficient brain showed striking changes in neuronal maturation. We recently showed that MeCP2 deficiency affects microtubule (MT) dynamics in RTT astrocytes. Here, we analyze MT stability in primary fibroblast cultures from patients with RTT syndrome and identify a significant decrease in stability compared to controls. Furthermore, we found that MT stability was reduced both in cells expressing the mutant or the wild\u2010type allele in RTT fibroblasts, suggesting that mutated cells could damage wild\u2010type ones through a non\u2010cell\u2010autonomous pathway. These results suggest that MeCP2 has a stabilizing role on MT dynamics and that its deficiency could lead to impaired MT stability that may explain in part the dendritic abnormalities observed in RTT brains.<\/jats:p>","DOI":"10.1016\/j.febslet.2012.11.033","type":"journal-article","created":{"date-parts":[[2012,12,10]],"date-time":"2012-12-10T18:47:12Z","timestamp":1355165232000},"page":"245-253","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"title":["MeCP2 deficiency is associated with impaired microtubule 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