{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T06:08:50Z","timestamp":1790057330774,"version":"4.0.1"},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,12,10]],"date-time":"2012-12-10T00:00:00Z","timestamp":1355097600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":995,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1"},{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":995,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["febsletters.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["FEBS Letters"],"published-print":{"date-parts":[[2013,1,16]]},"abstract":"<jats:p>\n                    This study focuses on clarifying the contribution of sulfation to radiation\u2010induced apoptosis in human Burkitt's lymphoma cell lines, using 3\u2032\u2010phosphoadenosine 5\u2032\u2010phosphosulfate transporters (PAPSTs). Overexpression of PAPST1 or PAPST2 reduced radiation\u2010induced apoptosis in Namalwa cells, whereas the repression of PAPST1 expression enhanced apoptosis. Inhibition of PAPST slightly decreased keratan sulfate (KS) expression, so that depletion of KS significantly increased radiation\u2010induced apoptosis. In addition, the repression of all three\n                    <jats:italic>N<\/jats:italic>\n                    \u2010acetylglucosamine\u20106\u2010\n                    <jats:italic>O<\/jats:italic>\n                    \u2010sulfotransferases (CHST2, CHST6, and CHST7) increased apoptosis. In contrast, PAPST1 expression promoted the phosphorylation of p38 MAPK and Akt in irradiated Namalwa cells. These findings suggest that 6\u2010\n                    <jats:italic>O<\/jats:italic>\n                    \u2010sulfation of GlcNAc residues in KS reduces radiation\u2010induced apoptosis of human Burkitt's lymphoma cells.\n                  <\/jats:p>","DOI":"10.1016\/j.febslet.2012.12.002","type":"journal-article","created":{"date-parts":[[2012,12,10]],"date-time":"2012-12-10T05:03:42Z","timestamp":1355115822000},"page":"231-237","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"title":["Sulfation of keratan sulfate proteoglycan reduces radiation\u2010induced apoptosis in human Burkitt's lymphoma cell lines"],"prefix":"10.1002","volume":"587","author":[{"given":"Fumiaki","family":"Nakayama","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sachiko","family":"Umeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomomi","family":"Ichimiya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin","family":"Kamiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaharu","family":"Hazawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Yasuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoko","family":"Nishihara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Imai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,12,10]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2008.09.001"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.49.29453"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M302439200"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M508991200"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/glycob\/cwq154"},{"key":"e_1_2_7_7_1","first-page":"2741","article-title":"Differential production of high molecular weight sulfated glycoproteins in normal colonic mucosa, primary colon carcinoma, and metastases","volume":"47","author":"Yamori T.","year":"1987","journal-title":"Cancer Res."},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2002.tb01285.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)41595-5"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1269\/jrr.08021"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/79987"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M002101200"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2000.3141"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/glycob\/10.10.951"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1986.tb09680.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj2340031"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1206701"},{"key":"e_1_2_7_18_1","unstructured":"Nakayama F. Umeda S. Yasuda T. Asada M. Motomura K. Suzuki M. Zakrzewska M. Imamura T. and Imai T. (in press). Structural stability of human fibroblast growth factor-1 is essential for protective effects against radiation-induced intestinal damage. Int. J. Radiat. Oncol. Biol. Phys. 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