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Under normal conditions, IAPP plays a role in the maintenance of energy homeostasis by regulating several metabolic parameters, such as satiety, blood glucose levels, adiposity and body weight. The mechanisms of IAPP amyloid formation, the nature of IAPP toxic species and the cellular pathways that lead to pancreatic \u03b2\u2010cell toxicity are not well characterized. Several mechanisms of toxicity, including receptor and non\u2010receptor\u2010mediated events, have been proposed. 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