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Several studies have reported that eIF4E is over\u2010expressed in cervical cancer; however, the mechanism remains elusive. The results of this study further confirm over\u2010expression of eIF4E in cervical cancer tumors and cell lines, and we have discovered that the transcription of eIF4E is induced by protein E6 of the human papillomavirus (HPV). Moreover, regulation of eIF4E by E6 significantly influences cell proliferation, the cell cycle, migration, and apoptosis. 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