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We previously demonstrated that overexpression of mitochondrial chaperone glucose\u2010regulated protein75 (Grp75\/mortalin) protects mitochondria. In this study we investigated the modulation of the lipopolisaccharide (LPS)\u2010induced inflammatory response of microglial BV\u20102 cells by Grp75. We demonstrate that LPS\u2010induced activation promotes significant metabolic changes suppressing mitochondrial function and increasing glycolysis. Overexpression of Grp75 attenuates the LPS\u2010induced oxidative and metabolic responses, and suppresses proinflammatory activation, which depends on both NF\u2010\u03baB activation and lactate. Thus overexpression of Grp75 provides a novel strategy to modulate proinflammatory cytokine production of relevance to inflammation\u2010associated pathologies.<\/jats:p>","DOI":"10.1016\/j.febslet.2013.01.067","type":"journal-article","created":{"date-parts":[[2013,2,8]],"date-time":"2013-02-08T04:03:03Z","timestamp":1360296183000},"page":"756-762","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":230,"title":["Inflammatory response of microglial BV\u20102 cells includes a glycolytic shift and is modulated by mitochondrial glucose\u2010regulated protein 75\/mortalin"],"prefix":"10.1002","volume":"587","author":[{"given":"Ludmila A.","family":"Voloboueva","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John F.","family":"Emery","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyun","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rona G.","family":"Giffard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,2,8]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2008.03634.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-004-0348-9"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12272-010-1006-7"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra022567"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mito.2010.05.014"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1980"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09663"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20102049"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2011.05.049"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20110367"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2006.05.011"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(03)00154-5"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.271726"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2002.tb02094.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00462.2004"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0802059"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199704103361506"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jcbfm.9600600"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2008.125"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-005-2996-1"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.4.1705"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-09-1676"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/PL00005349"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.490400612"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/0891-5849(94)90182-1"},{"key":"e_1_2_7_27_1","first-page":"105","article-title":"Edaravone, a newly developed radical scavenger, protects against ischemia&ndash;reperfusion injury of the small intestine in rats","volume":"13","author":"Tomatsuri N.","year":"2004","journal-title":"Int. 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