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Formate oxidoreductase activity was detected in blue native polyacrylamide gel electrophoresis (BN\u2010PAGE) resolved membranes of <jats:italic>E. coli<\/jats:italic>, which were also capable of cyanide sensitive formate:oxygen oxidoreductase activity. The latter was compromised in strains devoid of specific oxygen reductases, particularly, in those devoid of cytochrome <jats:italic>bo<\/jats:italic>\n<jats:sub>3<\/jats:sub> or <jats:italic>bdI<\/jats:italic>. A principal component analysis (PCA) integrating <jats:italic>E. coli<\/jats:italic> aerobic respiratory chain gene transcription, enzyme activity and growth dynamics was performed, correlating formate:oxygen oxidoreductase activity and the transcription of the genes encoding cytochromes <jats:italic>bo<jats:sub>3<\/jats:sub>\n<\/jats:italic> and <jats:italic>bdI<\/jats:italic>, and corroborating previous evidence that associated these complexes in FdOx.<\/jats:p>","DOI":"10.1016\/j.febslet.2013.06.031","type":"journal-article","created":{"date-parts":[[2013,7,2]],"date-time":"2013-07-02T06:01:50Z","timestamp":1372744910000},"page":"2559-2564","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["The formate:oxygen oxidoreductase supercomplex of <i>Escherichia coli<\/i> aerobic respiratory chain"],"prefix":"10.1002","volume":"587","author":[{"given":"Pedro M.F.","family":"Sousa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco A.M.","family":"Videira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana M.P.","family":"Melo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,7,2]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbabio.2009.02.019"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.06051-11"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4614-3573-0_5"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.52.30881"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)47736-8"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)89576-X"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2010.10.014"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.056531-0"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1128\/jb.173.16.4983-4993.1991"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/22.22.4673"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00871633"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M506479200"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2006.62"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)40989-7"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja01318a036"},{"key":"e_1_2_8_17_1","unstructured":"I.T. 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