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Y1030 was identified to be the major tyrosine phosphorylation site in MEGF10 and is phosphorylated at least in part by c\u2010Src. Overexpression of wild\u2010type MEGF10 enhanced C2C12 myoblast proliferation, while overexpression of Y1030F mutated MEGF10 did not. We conclude that MEGF10\u2010mediated signaling via tyrosine phosphorylation helps to regulate myoblast proliferation. 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