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Ectopic expression of miR\u201016 significantly inhibited cell proliferation and colony formation. Moreover, miR\u201016 suppressed cell migration and invasion in NSCLC cells. Hepatoma\u2010derived growth factor (HDGF) was found to be a direct target of miR\u201016 in NSCLC cell lines. Rescue experiments showed that the suppressive effect of miR\u201016 on cell proliferation, colony formation, migration, and invasion is partially mediated by inhibiting HDGF expression. 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