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We investigated the effects of the neuroendocrine secretory proteins 7B2 and proSAAS on hIAPP fibrillation in vitro and on cytotoxicity. In vitro, 21\u2010kDa 7B2 and proSAAS blocked hIAPP fibrillation. Structure\u2013function studies showed that a central region within 21\u2010kDa 7B2 is important in this effect and revealed the importance of the N\u2010terminal region of proSAAS. Both chaperones blocked the cytotoxic effects of exogenous hIAPP on Rin5f cells; 7B2 generated by overexpression was also effective. 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