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To refine the TRAK1\/2 binding sites within the kinesin\u20101 cargo domain, rationally designed C\u2010terminal truncations of KIF5A and KIF5C were generated and their co\u2010association with TRAK1\/2 determined by quantitative co\u2010immunoprecipitations following co\u2010expression in mammalian cells. Three contributory regions forming the TRAK2 binding site within KIF5A and KIF5C cargo binding domains were delineated. 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