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Loss of muscle mass, called muscle atrophy exacerbates disease\u2010associated metabolic perturbations. In this study, we characterized the molecular functions and mechanisms underlying regulation of skeletal muscle atrophy induced by denervation. Denervation significantly increased the expression of heme oxygenase\u20101 (HO\u20101) and atrogenes in skeletal muscle. Forkhead box protein O1 (FoxO1) drastically increased in atrophied muscle and selectively stimulated HO\u20101 gene transcription through direct DNA binding. Lack of HO\u20101 substantially attenuated muscle atrophy, whereas HO\u20101 overexpression caused muscle damage in vitro and in vivo. Collectively, HO\u20101 induced by FoxO1 may cause skeletal muscle atrophy.<\/jats:p>","DOI":"10.1016\/j.febslet.2013.11.009","type":"journal-article","created":{"date-parts":[[2013,11,21]],"date-time":"2013-11-21T12:24:58Z","timestamp":1385036698000},"page":"79-85","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["A FoxO1\u2010dependent, but NRF2\u2010independent induction of heme oxygenase\u20101 during muscle atrophy"],"prefix":"10.1002","volume":"588","author":[{"given":"Jione","family":"Kang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mi Gyeong","family":"Jeong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sera","family":"Oh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun 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