{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T03:08:24Z","timestamp":1791688104423,"version":"4.3.4"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,11,21]],"date-time":"2013-11-21T00:00:00Z","timestamp":1384992000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"University Paris Diderot, CNRS"},{"name":"Association Fran\u00e7aise contre les Myopathies"},{"DOI":"10.13039\/501100004543","name":"China Scholar Council","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["FEBS Letters"],"published-print":{"date-parts":[[2014,1,3]]},"abstract":"<jats:p>Muscle glycogen phosphorylase (GP) plays an important role in muscle functions. Mercury has toxic effects in skeletal muscle leading to muscle weakness or cramps. However, the mechanisms underlying these toxic effects are poorly understood. We report that GP is irreversibly inhibited by inorganic (Hg<jats:sup>2+<\/jats:sup>) and organic (CH<jats:sub>3<\/jats:sub>Hg<jats:sup>+<\/jats:sup>) mercury (IC<jats:sub>50<\/jats:sub>\n= 380 nM and <jats:italic>k<\/jats:italic>\n<jats:sub>inact<\/jats:sub>\n= 600 M<jats:sup>\u22121<\/jats:sup>\ns<jats:sup>\u22121<\/jats:sup> for Hg<jats:sup>2+<\/jats:sup> and IC<jats:sub>50<\/jats:sub>\n= 43 \u03bcM and <jats:italic>k<\/jats:italic>\n<jats:sub>inact<\/jats:sub>\n= 13 M<jats:sup>\u22121<\/jats:sup>\ns<jats:sup>\u22121<\/jats:sup> for CH<jats:sub>3<\/jats:sub>Hg<jats:sup>+<\/jats:sup>) through reaction of these compounds with cysteine residues of the enzyme. Our data suggest that the irreversible inhibition of GP could represent one of the mechanisms that contribute to mercury\u2010dependent muscle toxicity.<\/jats:p>","DOI":"10.1016\/j.febslet.2013.11.021","type":"journal-article","created":{"date-parts":[[2013,11,21]],"date-time":"2013-11-21T22:15:26Z","timestamp":1385072126000},"page":"138-142","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Skeletal muscle glycogen phosphorylase is irreversibly inhibited by mercury: Molecular, cellular and kinetic aspects"],"prefix":"10.1002","volume":"588","author":[{"given":"Ximing","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9cile","family":"Mathieu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sol\u00e8ne 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