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A novel all\u2010<jats:sc>d<\/jats:sc>\u2010amino\u2010acid from hIAPP \u03b2\u2010sheet core segment (hIAPP 22\u201327) is demonstrated to inhibit hIAPP fibril formation efficiently both at the phospholipid membrane and in bulk solution. The inhibitor terminates hIAPP aggregation to the \u03b1\u2010helical oligomeric intermediates at the membrane surface, whereas it stops the aggregation at the stage of \u03b2\u2010sheet oligomeric intermediates in bulk solution. 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