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On the molecular level, we observed inhibition of the non\u2010canonical Wnt\/planar\u2010cell\u2010polarity (PCP) pathway denoted by reduction of c\u2010jun\u2010n\u2010terminal\u2010kinase (JNK) phosphorylation. Upstream of JNK, increased protein levels of the Wnt\/PCP trans\u2010membrane receptor van\u2010Gogh\u2010like\u20102 (Vangl2) were observed along with an enrichment of Vangl2 in perinuclear located vesicles. The findings suggest that Dpr1 is essential for execution of the Wnt\/PCP pathway and regulation of the Vangl2\/JNK axis. 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