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To evaluate connections between KDACs and artemisinin,\n                    <jats:italic>Saccharomyces cerevisiae<\/jats:italic>\n                    deletion mutants in KDAC genes were assayed. Deletion of\n                    <jats:italic>RPD3<\/jats:italic>\n                    , but not other KDAC genes, resulted in strong sensitivity to artemisinin, which was also observed in\n                    <jats:italic>sit4<\/jats:italic>\n                    \u0394 mutants with impaired endoplasmic reticulum (ER) to Golgi protein trafficking. Decreased accumulation of the transporters Pdr5p, Fur4p, and Tat2p was observed in\n                    <jats:italic>rpd3<\/jats:italic>\n                    \u0394 and\n                    <jats:italic>sit4<\/jats:italic>\n                    \u0394 cells. The unfolded protein response is induced in\n                    <jats:italic>rpd3<\/jats:italic>\n                    \u0394 cells consistent with retention of proteins in the ER. Disruption of protein trafficking appears to sensitize cells to artemisinin and targeting these pathways may be useful as part of artemisinin based anti\u2010malarial therapy.\n                  <\/jats:p>","DOI":"10.1016\/j.febslet.2014.09.021","type":"journal-article","created":{"date-parts":[[2014,9,27]],"date-time":"2014-09-27T15:30:11Z","timestamp":1411831811000},"page":"4018-4025","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Improper protein trafficking contributes to artemisinin sensitivity in cells lacking the KDAC Rpd3p"],"prefix":"10.1002","volume":"588","author":[{"given":"Amornrat Naranuntarat","family":"Jensen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Worathad","family":"Chindaudomsate","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanate","family":"Thitiananpakorn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Skorn","family":"Mongkolsuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laran T.","family":"Jensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,9,27]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature03342"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60024-0"},{"key":"e_1_2_7_4_1","unstructured":"WHO 2013 World Health Organization Geneva Switzerland"},{"key":"e_1_2_7_5_1","first-page":"CD008492","article-title":"Artemisinin-based combination therapy for treating uncomplicated Plasmodium vivax malaria","volume":"10","author":"Gogtay N.","year":"2013","journal-title":"Cochrane Database Syst. 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