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Thus, we sought to characterize the lipid A structures of <jats:italic>Desulfovibrionaceae<\/jats:italic> lipopolysaccharides (LPS) that are associated with the microbiota inflammatory properties. LPS variants were obtained from two SRB isolates from the gut of a single individual. These LPS variants shared similar lipid A moieties with Enterobacterial LPS, but differed from one another with regard to fatty\u2010acid numbers and endotoxic activity. This first complete structural characterization of Desulfovibrio lipid A gives new insights into previously published data on Desulfovibrio lipid A biosynthesis. LPS microdiversity within SRBs illustrates how adaptation can influence pro\u2010inflammatory potential.<\/jats:p>","DOI":"10.1016\/j.febslet.2014.11.042","type":"journal-article","created":{"date-parts":[[2014,12,3]],"date-time":"2014-12-03T10:13:50Z","timestamp":1417601630000},"page":"165-171","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":86,"title":["<i>Desulfovibrio desulfuricans<\/i> isolates from the gut of a single individual: Structural and biological lipid A characterization"],"prefix":"10.1002","volume":"589","author":[{"given":"Wei","family":"Zhang-Sun","sequence":"first","affiliation":[{"name":"Equipe \u00abEndotoxins: Structures and Activities\u00bb, Institut de G\u00e9n\u00e9tique et Microbiologie, Universit\u00e9 Paris-Sud, CNRS UMR 8621, Orsay, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis A.","family":"Augusto","sequence":"additional","affiliation":[{"name":"Equipe \u00abEndotoxins: Structures and Activities\u00bb, Institut de G\u00e9n\u00e9tique et Microbiologie, Universit\u00e9 Paris-Sud, CNRS UMR 8621, Orsay, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liping","family":"Zhao","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Microbial Ecology and Ecogenomics, Department of Biological Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martine","family":"Caroff","sequence":"additional","affiliation":[{"name":"Equipe \u00abEndotoxins: Structures and Activities\u00bb, Institut de G\u00e9n\u00e9tique et Microbiologie, Universit\u00e9 Paris-Sud, CNRS UMR 8621, Orsay, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,12,3]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1152\/physiol.00023.2012"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/ismej.2012.153"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2013.03.007"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.2337\/db06-1491"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/09680519010070030101"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carres.2003.07.010"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/09680519010070020801"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/rcm.4960"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.01875-07"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1139\/o03-070"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2164(09)01202-7"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/30.11.1770"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/1574-6941.12228"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/ismej.2009.112"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1100\/2012\/647352"},{"key":"e_1_2_6_17_1","unstructured":"J.R. 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