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In HeLa cells, Pirin suppressed E\u2010cadherin expression and regulated the expression of other EMT markers. Furthermore, cells expressing Pirin exhibited a spindle\u2010like morphology, which is reminiscent of EMT. A Pirin mutant defective for Bcl3 binding decreased E\u2010cadherin expression similar to wild\u2010type, suggesting that Pirin regulates E\u2010cadherin independently of Bcl3\u2010Slug signaling. These data provide direct evidence that Pirin contributes to cancer metastasis.<\/jats:p>","DOI":"10.1016\/j.febslet.2015.01.040","type":"journal-article","created":{"date-parts":[[2015,2,11]],"date-time":"2015-02-11T01:17:11Z","timestamp":1423617431000},"page":"738-743","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Pirin regulates epithelial to mesenchymal transition independently of Bcl3\u2010Slug 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