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HMG\u2010CoA reductase inhibitor statins can induce liver injury by inhibiting GGPP. However, the function of\n                    <jats:italic>GGPPS<\/jats:italic>\n                    in liver injury has not yet been revealed. In this study, we found that\n                    <jats:italic>GGPPS<\/jats:italic>\n                    increased in liver injury and that\n                    <jats:italic>GGPPS<\/jats:italic>\n                    deletion augmented liver injury and fibrosis.\n                    <jats:italic>GGPPS<\/jats:italic>\n                    inhibition induced hepatocyte apoptosis, inflammation and TGF\u2010\u03b21 secretion, which activated hepatic stellate cells. Our findings imply that\n                    <jats:italic>GGPPS<\/jats:italic>\n                    deletion induces hepatocyte apoptosis, which makes the liver vulnerable to hepatotoxicity.\n                  <\/jats:p>","DOI":"10.1016\/j.febslet.2015.03.015","type":"journal-article","created":{"date-parts":[[2015,4,5]],"date-time":"2015-04-05T15:16:30Z","timestamp":1428246990000},"page":"1119-1126","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["<i>GGPPS<\/i>\n                    deficiency aggravates CCl\n                    <sub>4<\/sub>\n                    \u2010induced liver injury by inducing hepatocyte apoptosis"],"prefix":"10.1002","volume":"589","author":[{"given":"Wei-Bo","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shan-Shan","family":"Lai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"De-Cai","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shan","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan-Dan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi-Tao","family":"Ding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao-Jun","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Xue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,3,24]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI24282"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.65.070196.001325"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2009.07.033"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1240010"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.3646"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2004.02.037"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2221"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gde.2004.11.001"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2010.11.016"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20121806"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.4480"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-14-248"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2013.07.026"},{"key":"e_1_2_7_15_1","first-page":"764981","article-title":"Hepatic Stellate cell coculture enables sorafenib resistance in Huh7 Cells through HGF\/c-Met\/Akt and Jak2\/Stat3 pathways","volume":"2014","author":"Chen W.","year":"2014","journal-title":"Biomed. 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