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During the entire life cycle, mRNAs interact with distinct sets of <jats:italic>trans<\/jats:italic>\u2010acting factors that determine their fate at any given phase of gene expression. Recent studies have shown that mutations in components acting in <jats:italic>trans<\/jats:italic> on mRNAs are frequent causes of a large variety of different human disorders. The etiology of most of these diseases is, however, only poorly understood, mostly because the consequences for mRNA\u2010metabolism are unclear. Here we discuss three prominent genetic diseases that fall into this category, namely spinal muscular atrophy (SMA), retinitis pigmentosa (RP) and X\u2010linked syndromic mental retardation (XLMR). Whereas SMA and RP can be directly linked to mRNA processing, XLMR results from mutations in the mRNA surveillance system. We discuss how defects in mRNA maturation and turnover might lead to the tissue specific defects seen in these diseases.<\/jats:p>","DOI":"10.1016\/j.febslet.2015.04.052","type":"journal-article","created":{"date-parts":[[2015,5,14]],"date-time":"2015-05-14T00:49:18Z","timestamp":1431564558000},"page":"1598-1606","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["mRNA metabolism and neuronal disease"],"prefix":"10.1002","volume":"589","author":[{"given":"Bastian","family":"Linder","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Utz","family":"Fischer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niels 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