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G\u2010quadruplexes have been implicated in multiple cellular functions including chromatin epigenetic regulation, DNA recombination, transcriptional regulation of gene promoters and enhancers, and translation. Here we will review the evidence for the occurrence of G\u2010quadruplexes both in vitro and in vivo; their role in neurological diseases including G\u2010quadruplex\u2010forming repeat expansions in the <jats:italic>C9orf72<\/jats:italic> gene in frontotemporal dementia and amyotrophic lateral sclerosis and loss of the G\u2010quadruplex binding protein FMRP in the intellectual disability fragile X syndrome. We also review mounting evidence that supports a role for G\u2010quadruplexes in regulating the processing or function of a range of non\u2010coding RNAs. Finally we will highlight current perspectives for therapeutic interventions that target G\u2010quadruplexes.<\/jats:p>","DOI":"10.1016\/j.febslet.2015.05.003","type":"journal-article","created":{"date-parts":[[2015,5,13]],"date-time":"2015-05-13T00:30:22Z","timestamp":1431477022000},"page":"1653-1668","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":213,"title":["G\u2010quadruplexes: Emerging roles in neurodegenerative diseases and the non\u2010coding transcriptome"],"prefix":"10.1002","volume":"589","author":[{"given":"Roberto","family":"Simone","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pietro","family":"Fratta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Neidle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary N.","family":"Parkinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian M.","family":"Isaacs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,5,12]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkl655"},{"key":"e_1_2_9_3_1","article-title":"Quadruplex nucleic acids","author":"Neidle S.","year":"2006","journal-title":"R. 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