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Injection of high levels of lipopolysaccharide induces septic shock and death in mice within 30 h, whereas ceramide synthase 2 (CerS2) null mice, defective in the synthesis of very\u2010long acyl chain ceramides, die within \u223c10 h. The augmented rate of death of CerS2 null mice is due to elevated levels of TNF\u03b1 secretion as a result of enhanced activity of TNF\u03b1\u2010converting enzyme (TACE). 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