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Emerging evidence has demonstrated that the long ncRNAs (lncRNA) Human metastasis associated lung adenocarcinoma transcript 1 (MALAT1) participates in the regulation of the pathophysiological processes. However, whether there is crosstalk between CXCR2 and MALAT1 remains unknown. In this study, we demonstrated that MALAT1 was upregulated in patients with unstable angina. MALAT1 silencing significantly downregulated the expression of the miR\u201022\u20103p target gene CXCR2 via reversing the effect of the miR\u201022\u20103p, resulting in the aggravation of Oxidized low\u2010density lipoprotein (ox\u2010LDL)\u2010induced endothelial injury; this process was associated with the AKT pathway. 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