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Collagen V structure is not available and the disease\u2010causing mechanism is unclear. To address this issue, we manually curated missense mutations suspected to promote classic type EDS (cEDS) insurgence from the literature and performed a genotype\u2013phenotype correlation study. Further, we generated a homology model of the collagen V triple helix to evaluate the pathogenic effects. The resulting structure was used to map known protein\u2013protein interactions enriched with in silico predictions. An interaction network model for collagen V was created. 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