{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T13:14:21Z","timestamp":1762175661435},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004,6]]},"DOI":"10.1016\/j.femsim.2004.03.003","type":"journal-article","created":{"date-parts":[[2004,4,10]],"date-time":"2004-04-10T09:40:04Z","timestamp":1081590004000},"page":"161-167","source":"Crossref","is-referenced-by-count":47,"title":["The<i>Helicobacter pylori<\/i>plasticity region locus<i>jhp0947\u00e2\u0080\u0093jhp0949<\/i>is associated with duodenal ulcer disease and interleukin-12 production in monocyte cells"],"prefix":"10.1093","volume":"41","author":[{"given":"Ramon","family":"Jonge","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ernst J.","family":"Kuipers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabine C.L.","family":"Langeveld","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruud J.L.F.","family":"Loffeld","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeroen","family":"Stoof","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arnoud H.M.","family":"Vliet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes G.","family":"Kusters","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","reference":[{"key":"10.1016\/j.femsim.2004.03.003-BIB1","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1111\/j.1365-2036.1998.00009.x","article-title":"Review article: relationship between Helicobacter pylori, atrophic gastritis and gastric cancer","volume":"12","author":"Kuipers","year":"1998","journal-title":"Aliment. Pharmacol. Ther."},{"key":"10.1016\/j.femsim.2004.03.003-BIB2","doi-asserted-by":"crossref","first-page":"6265","DOI":"10.1128\/IAI.68.11.6265-6272.2000","article-title":"Modulation of innate cytokine responses by products of Helicobacter pylori","volume":"68","author":"Meyer","year":"2000","journal-title":"Infect. Immun."},{"key":"10.1016\/j.femsim.2004.03.003-BIB3","doi-asserted-by":"crossref","first-page":"4729","DOI":"10.4049\/jimmunol.156.12.4729","article-title":"Helicobacter-specific cell-mediated immune responses display a predominant Th1 phenotype and promote a delayed-type hypersensitivity response in the stomachs of mice","volume":"156","author":"Mohammadi","year":"1996","journal-title":"J. Immunol."},{"key":"10.1016\/j.femsim.2004.03.003-BIB4","doi-asserted-by":"crossref","first-page":"22","DOI":"10.3109\/00365529709025058","article-title":"Expression of mRNA for interferon-gamma, interleukin-10, and interleukin-12 (p40) in normal gastric mucosa and in mucosa infected with Helicobacter pylori","volume":"32","author":"Karttunen","year":"1997","journal-title":"Scand. J. Gastroenterol."},{"key":"10.1016\/j.femsim.2004.03.003-BIB5","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1111\/j.1574-6968.2001.tb10570.x","article-title":"The role of Helicobacter pylori virulence factors in interleukin production by monocytic cells","volume":"196","author":"Jonge","year":"2001","journal-title":"FEMS Microbiol. Lett."},{"key":"10.1016\/j.femsim.2004.03.003-BIB6","doi-asserted-by":"crossref","first-page":"4163","DOI":"10.1128\/IAI.71.7.4163-4166.2003","article-title":"Helicobacter pylori preferentially induces interleukin 12 (IL-12) rather than IL-6 or IL-10 in human dendritic cells","volume":"71","author":"Guiney","year":"2003","journal-title":"Infect. Immun."},{"key":"10.1016\/j.femsim.2004.03.003-BIB7","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1128\/IAI.63.5.1681-1687.1995","article-title":"Interleukin-8 response of gastric epithelial cell lines to Helicobacter pylori stimulation in vitro","volume":"63","author":"Sharma","year":"1995","journal-title":"Infect. Immun."},{"key":"10.1016\/j.femsim.2004.03.003-BIB8","doi-asserted-by":"crossref","first-page":"962","DOI":"10.4049\/jimmunol.158.2.962","article-title":"T helper 1 effector cells specific for Helicobacter pylori in the gastric antrum of patients with peptic ulcer disease","volume":"158","author":"D'Elios","year":"1997","journal-title":"J. Immunol."},{"key":"10.1016\/j.femsim.2004.03.003-BIB9","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1146\/annurev.iy.13.040195.001343","article-title":"Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity","volume":"13","author":"Trinchieri","year":"1995","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.femsim.2004.03.003-BIB10","doi-asserted-by":"crossref","first-page":"2534","DOI":"10.1128\/IAI.71.5.2534-2541.2003","article-title":"Development of an interleukin-12-deficient mouse model that is permissive for colonization by a motile KE26695 strain of Helicobacter pylori","volume":"71","author":"Hoffman","year":"2003","journal-title":"Infect. Immun."},{"key":"10.1016\/j.femsim.2004.03.003-BIB11","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1046\/j.1365-2249.1999.00968.x","article-title":"Production of IL-12 in gastritis relates to infection with Helicobacter pylori","volume":"117","author":"Bauditz","year":"1999","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.femsim.2004.03.003-BIB12","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0167-7012(02)00136-7","article-title":"Direct random insertion mutagenesis of Helicobacter pylori","volume":"52","author":"deJonge","year":"2003","journal-title":"J. Microbiol. Meth."},{"key":"10.1016\/j.femsim.2004.03.003-BIB13","doi-asserted-by":"crossref","first-page":"5791","DOI":"10.1073\/pnas.90.12.5791","article-title":"Molecular characterization of the 128-kDa immunodominant antigen of Helicobacter pylori associated with cytotoxicity and duodenal ulcer","volume":"90","author":"Covacci","year":"1993","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.femsim.2004.03.003-BIB14","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1046\/j.1365-2958.1998.00806.x","article-title":"Metronidazole resistance in Helicobacter pylori is due to null mutations in a gene (rdxA) that encodes an oxygen-insensitive NADPH nitroreductase","volume":"28","author":"Goodwin","year":"1998","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.femsim.2004.03.003-BIB15","unstructured":"[15] Sambrook, J., Fritsch, E.F., Maniatis, T. (1989) Molecular cloning, a laboratory manual, 2nd ed. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY."},{"key":"10.1016\/j.femsim.2004.03.003-BIB16","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S0167-7012(00)00159-7","article-title":"Efficient amplification of multiple transposon-flanking sequences","volume":"41","author":"Kwon","year":"2000","journal-title":"J. Microbiol. Meth."},{"key":"10.1016\/j.femsim.2004.03.003-BIB17","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1111\/j.1574-695X.2000.tb01468.x","article-title":"IgG antibody titer against Helicobacter pylori correlates with presence of cytotoxin associated gene A-positive H. pylori strains","volume":"28","author":"Loffeld","year":"2000","journal-title":"FEMS Immunol. Med. Microbiol."},{"key":"10.1016\/j.femsim.2004.03.003-BIB18","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1038\/16495","article-title":"Genomic-sequence comparison of two unrelated isolates of the human gastric pathogen Helicobacter pylori","volume":"397","author":"Alm","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.femsim.2004.03.003-BIB19","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1038\/41483","article-title":"The complete genome sequence of the gastric pathogen Helicobacter pylori","volume":"388","author":"Tomb","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.femsim.2004.03.003-BIB20","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1046\/j.1462-5822.2003.00286.x","article-title":"Structural definition on the surface of Helicobacter pylori type IV secretion apparatus","volume":"5","author":"Tanaka","year":"2003","journal-title":"Cell Microbiol."},{"key":"10.1016\/j.femsim.2004.03.003-BIB21","doi-asserted-by":"crossref","first-page":"6240","DOI":"10.1128\/IAI.68.11.6240-6249.2000","article-title":"Distribution of open reading frames of plasticity region of strain J99 in Helicobacter pylori strains isolated from gastric carcinoma and gastritis patients in Costa Rica","volume":"68","author":"Occhialini","year":"2000","journal-title":"Infect. Immun."},{"key":"10.1016\/j.femsim.2004.03.003-BIB22","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1128\/JCM.41.4.1651-1655.2003","article-title":"New pathogenicity marker found in the plasticity region of the Helicobacter pylori genome","volume":"41","author":"Santos","year":"2003","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.femsim.2004.03.003-BIB23","doi-asserted-by":"crossref","first-page":"2274","DOI":"10.1128\/JCM.37.7.2274-2279.1999","article-title":"Relationship between Helicobacter pylori iceA, cagA, and vacA status and clinical outcome: studies in four different countries","volume":"37","author":"Yamaoka","year":"1999","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.femsim.2004.03.003-BIB24","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1111\/j.1083-4389.2004.00213.x","article-title":"The functional status of the Helicobacter pylori sabB adhesin gene as a putative marker for disease outcome","volume":"9","author":"Jonge","year":"2004","journal-title":"Helicobacter"}],"container-title":["FEMS Immunology &amp; Medical Microbiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/femspd\/article-pdf\/41\/2\/161\/19167456\/41-2-161.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,28]],"date-time":"2023-04-28T07:17:00Z","timestamp":1682666220000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/femspd\/article-lookup\/doi\/10.1016\/j.femsim.2004.03.003"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,6]]},"references-count":24,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2004,6]]}},"URL":"https:\/\/doi.org\/10.1016\/j.femsim.2004.03.003","relation":{},"ISSN":["0928-8244","1574-695X"],"issn-type":[{"value":"0928-8244","type":"print"},{"value":"1574-695X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,6]]}}}