{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,1,14]],"date-time":"2024-01-14T00:05:29Z","timestamp":1705190729381},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004,10]]},"DOI":"10.1016\/j.femsim.2004.05.007","type":"journal-article","created":{"date-parts":[[2004,6,16]],"date-time":"2004-06-16T11:57:45Z","timestamp":1087387065000},"page":"233-239","source":"Crossref","is-referenced-by-count":3,"title":["Cell mediated immune response elicited in mice after immunization with the P64k meningococcal protein: epitope mapping"],"prefix":"10.1093","volume":"42","author":[{"given":"Sonia","family":"Gonz\u00c3\u00a1lez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Consuelo","family":"Naz\u00c3\u00a1bal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kanury V.S.","family":"Rao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osvaldo","family":"Reyes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hilda E.","family":"Garay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evelin","family":"Caballero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julio C.","family":"Alvarez-Obreg\u00c3\u00b3n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gretel","family":"Sardi\u00c3\u00b1as","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo","family":"Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","reference":[{"key":"10.1016\/j.femsim.2004.05.007-BIB1","doi-asserted-by":"crossref","first-page":"347","DOI":"10.2165\/00003495-199855030-00003","article-title":"Meningococcal vaccines. Current status and future possibilities","volume":"55","author":"Peltola","year":"1998","journal-title":"Drugs"},{"key":"10.1016\/j.femsim.2004.05.007-BIB2","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1111\/j.1470-8744.1998.tb00494.x","article-title":"Expression in Escherichia coli of the lpdA gene, protein sequence analysis and immunological characterization of the P64k protein from Neisseria meningitidis","volume":"27","author":"Guill\u00c3\u00a9n","year":"1998","journal-title":"Biotechnol. Appl. Biochem"},{"key":"10.1016\/j.femsim.2004.05.007-BIB3","first-page":"83","article-title":"Functional and structural characterization of the recombinant P64k protein of Neisseria meningitidis","volume":"16","author":"G\u00c3\u00b3mez","year":"1999","journal-title":"Biotecnolog\u00c3\u00ada Aplicada"},{"key":"10.1016\/j.femsim.2004.05.007-BIB4","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1006\/jmbi.1997.1009","article-title":"Molecular structure of the lipoamide dehydrogenase domain of a surface antigen from Neisseria meningitidis","volume":"269","author":"Li","year":"1997","journal-title":"J. Mol. Biol"},{"key":"10.1016\/j.femsim.2004.05.007-BIB5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/BA19990115","article-title":"B-cell epitope mapping of the Neisseria meningitidis P64k protein using overlapping peptides","volume":"32","author":"Gonz\u00c3\u00a1lez","year":"2000","journal-title":"Biotechnol. Appl. Biochem"},{"key":"10.1016\/j.femsim.2004.05.007-BIB6","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1046\/j.1365-3083.2000.00788.x","article-title":"P64k meningococcal protein as immunological carrier for weak immunogens","volume":"52","author":"Gonz\u00c3\u00a1lez","year":"2000","journal-title":"Scand. J. Immunol"},{"key":"10.1016\/j.femsim.2004.05.007-BIB7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1023\/A:1008261031034","article-title":"A novel cancer vaccine composed of human recombinant epidermal growth factor linked to a carrier protein: Report of a pilot clinical trial","volume":"9","author":"Gonz\u00c3\u00a1lez","year":"1998","journal-title":"Ann. Oncol"},{"key":"10.1016\/j.femsim.2004.05.007-BIB8","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1139\/w00-133","article-title":"Mapping of monoclonal antibodies specific to P64k: a common antigen of several isolates of Neisseria meningitidis","volume":"47","author":"Naz\u00c3\u00a1bal","year":"2001","journal-title":"Can. J. Microbiol"},{"key":"10.1016\/j.femsim.2004.05.007-BIB9","unstructured":"[9] United States Pharmacopeia-USP XXIV (2000), United States Pharmacopeia Convention, 24\u00e2\u0080\u009319 ed"},{"key":"10.1016\/j.femsim.2004.05.007-BIB10","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1111\/j.1470-8744.1999.tb00540.x","article-title":"Preformulation study of the vaccine candidate P64k against Neisseria meningitidis","volume":"29","author":"Exp\u00c3\u00b3sito","year":"1999","journal-title":"Biotechnol. Appl. Biochem"},{"key":"10.1016\/j.femsim.2004.05.007-BIB11","doi-asserted-by":"crossref","unstructured":"[11] Mills, K.H.G. (1996) Induction and detection of T-cell responses. In: Vaccine Protocols (Robinson, A., Farrar, G.H., Wiblin, C.N., Eds.), pp.197\u00e2\u0080\u0093222 Humana Press, Totowa, NJ.","DOI":"10.1385\/0-89603-334-1:197"},{"key":"10.1016\/j.femsim.2004.05.007-BIB12","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1097\/00001432-198912000-00014","article-title":"Recognition of foreign antigen by T cells and their role in immune protection","volume":"2","author":"Mills","year":"1989","journal-title":"Curr. Opinion Infect. Dis"},{"key":"10.1016\/j.femsim.2004.05.007-BIB13","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/0167-5699(86)90006-X","article-title":"Processing of viral antigens and presentation to class II-restricted T cells","volume":"7","author":"Mills","year":"1986","journal-title":"Immunol. Today"},{"key":"10.1016\/j.femsim.2004.05.007-BIB14","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1146\/annurev.iy.07.040189.001045","article-title":"TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties","volume":"7","author":"Mosmann","year":"1989","journal-title":"Annu. Rev. Immunol"},{"key":"10.1016\/j.femsim.2004.05.007-BIB15","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/0264-410X(93)90190-9","article-title":"Adjuvants \u00e2\u0080\u0093 a balance between toxicity and adjuvanticity","volume":"11","author":"Gupta","year":"1993","journal-title":"Vaccine"},{"key":"10.1016\/j.femsim.2004.05.007-BIB16","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/S0952-7915(00)00120-5","article-title":"Immunological concepts of vaccine adjuvant activity","volume":"12","author":"Schijns","year":"2000","journal-title":"Curr. Opin. Immunol"},{"key":"10.1016\/j.femsim.2004.05.007-BIB17","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1016\/0264-410X(95)00011-O","article-title":"Adjuvants for human vaccines \u00e2\u0080\u0093 current status, problems and future prospects","volume":"13","author":"Gupta","year":"1995","journal-title":"Vaccine"},{"key":"10.1016\/j.femsim.2004.05.007-BIB18","first-page":"269","article-title":"Influence of several adjuvants on the immune response against a recombinant meningococcal high molecular weight antigen","volume":"92","author":"Gonzalez","year":"1998","journal-title":"Dev. Biol. Stand"},{"key":"10.1016\/j.femsim.2004.05.007-BIB19","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/j.1600-065X.1988.tb00771.x","article-title":"Antigen processing for presentation to T lymphocytes: function, mechanisms, and implications for the T-cell repertoire","volume":"106","author":"Berzofsky","year":"1988","journal-title":"Immunol. Rev"},{"key":"10.1016\/j.femsim.2004.05.007-BIB20","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/0268-960X(92)90025-L","article-title":"Detection and measurement of cytokines","volume":"6","author":"Thorpe","year":"1992","journal-title":"Blood Rev"},{"key":"10.1016\/j.femsim.2004.05.007-BIB21","doi-asserted-by":"crossref","first-page":"3445","DOI":"10.4049\/jimmunol.141.10.3445","article-title":"Characterization of T helper 1 and 2 cell subsets in normal mice. Helper T cells responsible for IL-4 and IL-5 production are present as precursors that require priming before they develop into lymphokine-secreting cells","volume":"141","author":"Swain","year":"1988","journal-title":"J. Immunol"},{"key":"10.1016\/j.femsim.2004.05.007-BIB22","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/j.1600-065X.1988.tb00739.x","article-title":"The role of helper T cell products in mouse B cell differentiation and isotype regulation","volume":"102","author":"Coffman","year":"1988","journal-title":"Immunol. Rev"},{"key":"10.1016\/j.femsim.2004.05.007-BIB23","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1002\/j.1460-2075.1987.tb02360.x","article-title":"Mapping of T cell epitopes using recombinant antigens and synthetic peptides","volume":"6","author":"Lamb","year":"1987","journal-title":"EMBO J"},{"key":"10.1016\/j.femsim.2004.05.007-BIB24","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/0022-1759(90)90108-8","article-title":"Multi-pin peptide synthesis strategy for T cell determinant analysis","volume":"134","author":"Maeji","year":"1990","journal-title":"J. Immunol. Meth"},{"key":"10.1016\/j.femsim.2004.05.007-BIB25","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1111\/j.1699-0463.1993.tb00161.x","article-title":"The involvement of antigen processing in determinant selection by class II MHC and its relationship to immunodominance","volume":"101","author":"Deng","year":"1993","journal-title":"APMIS"},{"key":"10.1016\/j.femsim.2004.05.007-BIB26","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1128\/IAI.66.2.786-793.1998","article-title":"Mapping of the T-cell epitope in the major 43-kilodalton glycoprotein of Paracoccidioides brasiliensis which induces a Th-1 response protective against fungal infection in BALB\/c mice","volume":"66","author":"Taborda","year":"1998","journal-title":"Infect. Immun"},{"key":"10.1016\/j.femsim.2004.05.007-BIB27","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/0168-1702(95)00016-J","article-title":"A helper T-cell epitope of the E7 protein of human papillomavirus type 16 in BALB\/c mice","volume":"37","author":"Vandebriel","year":"1995","journal-title":"Virus Res"},{"key":"10.1016\/j.femsim.2004.05.007-BIB28","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1006\/clin.1997.4437","article-title":"T-Cell epitope mapping the PorB protein of serogroup B Neisseria meningitidis in B10 congenic strains of mice","volume":"85","author":"Delvig","year":"1997","journal-title":"Clin. Immunol. Immunopathol"},{"key":"10.1016\/j.femsim.2004.05.007-BIB29","unstructured":"[29] Duarte, C., Guill\u00c3\u00a9n, G., Alvarez, A., Carpio, E., Quintana, D., G\u00c3\u00b3mez, C.E., Silva, R., Nazabal, C., Leal, M.J., Martin, A. System for the expression of heterologous antigens as fusion proteins. European Patent EP 0 816 506"},{"key":"10.1016\/j.femsim.2004.05.007-BIB30","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1093\/bioinformatics\/17.12.1236","article-title":"ProPred: prediction of HLA-DR binding sites","volume":"17","author":"Singh","year":"2001","journal-title":"Bioinformatics"},{"key":"10.1016\/j.femsim.2004.05.007-BIB31","doi-asserted-by":"crossref","unstructured":"[31] Swain, M.T., Brooks, A.J., Kemp, G.J.L. (2001) An automated approach to modelling class II MHC alleles and predicting peptide binding. In: Proceedings of the Second IEEE International Symposium on Bio-Informatics and Biomedical Engineering, pp. 81\u00e2\u0080\u009388. IEEE Computer Society Press","DOI":"10.1109\/BIBE.2001.974415"},{"key":"10.1016\/j.femsim.2004.05.007-BIB32","doi-asserted-by":"crossref","first-page":"163","DOI":"10.4049\/jimmunol.152.1.163","article-title":"Scheme for ranking potential HLA-A2 binding peptides based on independent binding of individual peptide side-chains","volume":"152","author":"Parker","year":"1994","journal-title":"J. Immunol"},{"key":"10.1016\/j.femsim.2004.05.007-BIB33","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/S0198-8859(02)00432-9","article-title":"Prediction of MHC class I binding peptides using profile motifs","volume":"63","author":"Reche","year":"2002","journal-title":"Hum. Immunol"},{"key":"10.1016\/j.femsim.2004.05.007-BIB34","doi-asserted-by":"crossref","first-page":"2237","DOI":"10.1002\/eji.1830191209","article-title":"Universally immunogenic T cell epitopes: promiscuous binding to human MHC class II and promiscuous recognition by T cells","volume":"19","author":"Panina-Bordignon","year":"1989","journal-title":"Eur. J. Immunol"},{"key":"10.1016\/j.femsim.2004.05.007-BIB35","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1038\/317359a0","article-title":"Binding of immunogenic peptides to Ia histocompatibility molecules","volume":"317","author":"Babbitt","year":"1985","journal-title":"Nature"},{"key":"10.1016\/j.femsim.2004.05.007-BIB36","doi-asserted-by":"crossref","first-page":"3968","DOI":"10.1073\/pnas.83.11.3968","article-title":"Interaction between a processed ovalbumin peptide and Ia molecules","volume":"83","author":"Buus","year":"1986","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.femsim.2004.05.007-BIB37","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1038\/324260a0","article-title":"Interaction of peptide antigens and class II major histocompatibility complex antigens","volume":"324","author":"Guillet","year":"1986","journal-title":"Nature"},{"key":"10.1016\/j.femsim.2004.05.007-BIB38","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1042\/BA20010029","article-title":"Safety and preliminary immunogenicity of the recombinant outer membrane protein P64k of Neisseria meningitidis in human volunteers","volume":"34","author":"Perez","year":"2001","journal-title":"Biotechnol. Appl. Biochem"}],"container-title":["FEMS Immunology &amp; Medical Microbiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/femspd\/article-pdf\/42\/2\/233\/19167821\/42-2-233.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,13]],"date-time":"2024-01-13T17:17:27Z","timestamp":1705166247000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/femspd\/article-lookup\/doi\/10.1016\/j.femsim.2004.05.007"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,10]]},"references-count":38,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2004,10]]}},"URL":"https:\/\/doi.org\/10.1016\/j.femsim.2004.05.007","relation":{},"ISSN":["0928-8244","1574-695X"],"issn-type":[{"value":"0928-8244","type":"print"},{"value":"1574-695X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,10]]}}}