{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T10:47:45Z","timestamp":1775213265773,"version":"3.50.1"},"reference-count":48,"publisher":"Oxford University Press (OUP)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,2]]},"DOI":"10.1016\/j.femsim.2004.11.006","type":"journal-article","created":{"date-parts":[[2004,12,16]],"date-time":"2004-12-16T00:01:49Z","timestamp":1103155309000},"page":"115-124","source":"Crossref","is-referenced-by-count":71,"title":["Immunobiology of hookworm infection"],"prefix":"10.1093","volume":"43","author":[{"given":"Alex","family":"Loukas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie L.","family":"Constant","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey M.","family":"Bethony","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","reference":[{"key":"10.1016\/j.femsim.2004.11.006-BIB1","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1016\/S0020-7519(03)00158-9","article-title":"Progress in the development of a recombinant vaccine for human hookworm disease: the Human Hookworm Vaccine Initiative","volume":"33","author":"Hotez","year":"2003","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.femsim.2004.11.006-BIB2","unstructured":"[2] Behnke, J.M. Immunology Gilles, H.M., Ball, P.A.J., Eds. Human parasitic diseases, Hookworm infections vol. 4 1991 Elsevier Amsterdam93 155"},{"key":"10.1016\/j.femsim.2004.11.006-BIB3","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1128\/CMR.14.4.689-703.2001","article-title":"Immune responses in hookworm infections","volume":"14","author":"Loukas","year":"2001","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.femsim.2004.11.006-BIB4","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1056\/NEJMra032492","article-title":"Hookworm infection","volume":"351","author":"Hotez","year":"2004","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.femsim.2004.11.006-BIB5","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1097\/00001432-200410000-00006","article-title":"Hookworm infection: new developments and prospects for control","volume":"17","author":"Bungiro","year":"2004","journal-title":"Curr. Opin. Infect. Dis."},{"key":"10.1016\/j.femsim.2004.11.006-BIB6","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1016\/0140-6736(90)91186-E","article-title":"Human eosinophilic enteritis caused by dog hookworm Ancylostoma caninum","volume":"335","author":"Prociv","year":"1990","journal-title":"Lancet"},{"key":"10.1016\/j.femsim.2004.11.006-BIB7","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.4269\/ajtmh.1966.15.1032","article-title":"The nature and causes of hookworm anemia","volume":"15","author":"Roche","year":"1966","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.femsim.2004.11.006-BIB8","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/S0959-437X(96)80092-X","article-title":"Hookworm: developmental biology of the infectious process","volume":"6","author":"Hawdon","year":"1996","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.1016\/j.femsim.2004.11.006-BIB9","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/S0020-7519(03)00088-2","article-title":"The second messenger cyclic GMP mediates activation in Ancylostoma caninum infective larvae","volume":"33","author":"Hawdon","year":"2003","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.femsim.2004.11.006-BIB10","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S1471-4922(03)00189-2","article-title":"Digestive proteases of blood-feeding nematodes","volume":"19","author":"Williamson","year":"2003","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.femsim.2004.11.006-BIB11","doi-asserted-by":"crossref","first-page":"2149","DOI":"10.1073\/pnas.93.5.2149","article-title":"Anticoagulant repertoire of the hookworm Ancylostoma caninum","volume":"93","author":"Stassens","year":"1996","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.femsim.2004.11.006-BIB12","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1016\/j.ijpara.2004.04.013","article-title":"A pore-forming haemolysin from the hookworm, Ancylostoma caninum","volume":"34","author":"Don","year":"2004","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.femsim.2004.11.006-BIB13","doi-asserted-by":"crossref","first-page":"35950","DOI":"10.1074\/jbc.M405842200","article-title":"A multi-enzyme cascade of hemoglobin proteolysis in the intestine of blood-feeding hookworms","volume":"279","author":"Williamson","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.femsim.2004.11.006-BIB14","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1038\/ng1237","article-title":"Transcriptome analysis of the acoelomate human parasite Schistosoma mansoni","volume":"35","author":"Verjovski-Almeida","year":"2003","journal-title":"Nat. Genet."},{"key":"10.1016\/j.femsim.2004.11.006-BIB15","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S1471-4922(01)01941-9","article-title":"Is Necator americanus approaching a mutualistic symbiotic relationship with humans","volume":"17","author":"Pritchard","year":"2001","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.femsim.2004.11.006-BIB16","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/0169-4758(95)80206-1","article-title":"The survival strategies of hookworms","volume":"11","author":"Pritchard","year":"1995","journal-title":"Parasitol. Today"},{"key":"10.1016\/j.femsim.2004.11.006-BIB17","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1111\/j.1365-3024.1995.tb01005.x","article-title":"The specificity of the human IgE response to Necator americanus","volume":"17","author":"Pritchard","year":"1995","journal-title":"Parasite Immunol."},{"key":"10.1016\/j.femsim.2004.11.006-BIB18","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1111\/j.1365-3024.1995.tb00968.x","article-title":"Immunity in humans to Necator americanus: IgE, parasite weight and fecundity","volume":"17","author":"Pritchard","year":"1995","journal-title":"Parasite Immunol."},{"key":"10.1016\/j.femsim.2004.11.006-BIB19","doi-asserted-by":"crossref","first-page":"126","DOI":"10.4269\/ajtmh.1987.37.126","article-title":"The clinical and immunologic responses of normal human volunteers to low dose hookworm (Necator americanus) infection","volume":"37","author":"Maxwell","year":"1987","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.femsim.2004.11.006-BIB20","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1093\/infdis\/154.5.778","article-title":"Changes in the structural and functional properties of human eosinophils during experimental hookworm infection","volume":"154","author":"White","year":"1986","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.femsim.2004.11.006-BIB21","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1086\/344268","article-title":"Emerging patterns of hookworm infection: influence of aging on the intensity of Necator infection in Hainan Province, People's Republic of China","volume":"35","author":"Bethony","year":"2002","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.femsim.2004.11.006-BIB22","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1111\/j.1365-3024.1995.tb00897.x","article-title":"Immunoepidemiology of human necatoriasis: correlations between antibody responses and parasite burdens","volume":"17","author":"Quinnell","year":"1995","journal-title":"Parasite Immunol."},{"key":"10.1016\/j.femsim.2004.11.006-BIB23","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1111\/j.1365-2249.2004.02449.x","article-title":"Cellular responses and cytokine production in post-treatment hookworm patients from an endemic area in Brazil","volume":"136","author":"Geiger","year":"2004","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.femsim.2004.11.006-BIB24","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1086\/422256","article-title":"Immune responses in human necatoriasis: association between interleukin-5 responses and resistance to reinfection","volume":"190","author":"Quinnell","year":"2004","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.femsim.2004.11.006-BIB25","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1034\/j.1398-9995.2000.00477.x","article-title":"Prenatal immune priming with helminth infections: parasite-specific cellular reactivity and Th1 and Th2 cytokine responses in neonates","volume":"55","author":"Pit","year":"2000","journal-title":"Allergy"},{"key":"10.1016\/j.femsim.2004.11.006-BIB26","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1007\/s004360100419","article-title":"Parasite-specific antibody and cellular immune responses in human infected with Necator americanus and Oesophagostomum bifurcum","volume":"87","author":"Pit","year":"2001","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.femsim.2004.11.006-BIB27","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/nri843","article-title":"The immunobiology of schistosomiasis","volume":"2","author":"Pearce","year":"2002","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.femsim.2004.11.006-BIB28","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1046\/j.1365-3024.1998.00151.x","article-title":"Profound suppression of cellular proliferation mediated by the secretions of nematodes","volume":"20","author":"Allen","year":"1998","journal-title":"Parasite Immunol."},{"key":"10.1016\/j.femsim.2004.11.006-BIB29","doi-asserted-by":"crossref","first-page":"2699","DOI":"10.4049\/jimmunol.173.4.2699","article-title":"A secreted protein from the human hookworm Necator americanus binds selectively to NK cells and induces IFN-\u00ce\u00b3 production","volume":"173","author":"Hsieh","year":"2004","journal-title":"J. Immunol."},{"key":"10.1016\/j.femsim.2004.11.006-BIB30","doi-asserted-by":"crossref","first-page":"10008","DOI":"10.1016\/S0021-9258(17)36982-X","article-title":"A hookworm glycoprotein that inhibits neutrophil function is a ligand of the integrin CD11b\/CD18","volume":"269","author":"Moyle","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.femsim.2004.11.006-BIB31","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0166-6851(03)00121-X","article-title":"Isolation and molecular cloning of a secreted hookworm platelet inhibitor from adult Ancylostoma caninum","volume":"129","author":"Valle","year":"2003","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.femsim.2004.11.006-BIB32","doi-asserted-by":"crossref","first-page":"6447","DOI":"10.4049\/jimmunol.165.11.6447","article-title":"Eotaxin is specifically cleaved by hookworm metalloproteases preventing its action in vitro and in vivo","volume":"165","author":"Culley","year":"2000","journal-title":"J. Immunol."},{"key":"10.1016\/j.femsim.2004.11.006-BIB33","doi-asserted-by":"crossref","first-page":"705","DOI":"10.2307\/3276143","article-title":"Persistence of immunity following double vaccination of pups with x-irradiated Ancylostoma caninum larvae","volume":"51","author":"Miller","year":"1965","journal-title":"J. Parasitol."},{"key":"10.1016\/j.femsim.2004.11.006-BIB34","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/S0065-308X(08)60577-1","article-title":"Industrial development and field use of the canine hookworm vaccine","volume":"16","author":"Miller","year":"1978","journal-title":"Adv. Parasitol."},{"key":"10.1016\/j.femsim.2004.11.006-BIB35","first-page":"231","article-title":"Transfer of immunity to Ancylostoma caninum infection in pups by serum and lymphoid cells","volume":"12","author":"Miller","year":"1967","journal-title":"Immunology"},{"key":"10.1016\/j.femsim.2004.11.006-BIB36","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0304-4017(01)00480-0","article-title":"Vaccination against gastrointestinal nematode parasites of ruminants using gut-expressed antigens","volume":"100","author":"Knox","year":"2001","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.femsim.2004.11.006-BIB37","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0166-6851(99)00011-0","article-title":"Ancylostoma secreted protein 2: cloning and characterization of a second member of a family of nematode secreted proteins from Ancylostoma caninum","volume":"99","author":"Hawdon","year":"1999","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.femsim.2004.11.006-BIB38","doi-asserted-by":"crossref","first-page":"6672","DOI":"10.1074\/jbc.271.12.6672","article-title":"Cloning and characterization of Ancylostoma-secreted protein. A novel protein associated with the transition to parasitism by infective hookworm larvae","volume":"271","author":"Hawdon","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.femsim.2004.11.006-BIB39","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/S0166-6851(01)00453-4","article-title":"A developmentally regulated metalloprotease secreted by host-stimulated Ancylostoma caninum third-stage infective larvae is a member of the astacin family of proteases","volume":"120","author":"Zhan","year":"2002","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.femsim.2004.11.006-BIB40","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1093\/infdis\/174.6.1380","article-title":"Vaccination with alum-precipitated recombinant Ancylostoma-secreted protein1 protects mice against challenge infections with infective hookworm (Ancylostoma caninum) larvae","volume":"174","author":"Ghosh","year":"1996","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.femsim.2004.11.006-BIB41","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1086\/381901","article-title":"Cloning, yeast expression, isolation and vaccine testing of recombinant Ancylostoma secreted protein 1 (ASP-1) and ASP-2 from Ancylostoma ceylanicum","volume":"189","author":"Goud","year":"2004","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.femsim.2004.11.006-BIB42","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1645\/GE-46R","article-title":"Effect of vaccination with a recombinant fusion protein encoding an astacin-like metalloprotease (MTP-1) secreted by host-stimulated Ancylostoma caninum third-stage infective larvae","volume":"89","author":"Hotez","year":"2003","journal-title":"J. Parasitol."},{"key":"10.1016\/j.femsim.2004.11.006-BIB43","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.4049\/jimmunol.143.4.1346","article-title":"Immunologic control of a parasitic arthropod. Identification of a protective antigen from Boophilus microplus","volume":"143","author":"Willadsen","year":"1989","journal-title":"J. Immunol."},{"key":"10.1016\/j.femsim.2004.11.006-BIB44","doi-asserted-by":"crossref","unstructured":"[44] Knox, D.P., Skuce, P.J., Newlands, G.F., Redmond, D.L. Nematode gut peptidases, proteins and vaccination Kennedy, M.W., Harnett, W., Eds. Parasitic Nematodes: Molecular Biology, Biochemistry and Immunology 2001 CAB International New York247 268","DOI":"10.1079\/9780851994239.0247"},{"key":"10.1016\/j.femsim.2004.11.006-BIB45","doi-asserted-by":"crossref","first-page":"1952","DOI":"10.1086\/386346","article-title":"Vaccination of dogs with a recombinant cysteine protease from the intestine of canine hookworms diminishes the fecundity and growth of worms","volume":"189","author":"Loukas","year":"2004","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.femsim.2004.11.006-BIB46","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1016\/j.addr.2003.10.033","article-title":"Helminths at mucosal barriers \u00e2\u0080\u0093 interaction with the immune system","volume":"56","author":"Mulcahy","year":"2004","journal-title":"Adv. Drug. Deliv. Rev."},{"key":"10.1016\/j.femsim.2004.11.006-BIB47","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1289\/ehp.02110537","article-title":"Estimating the burden of disease from water, sanitation, and hygiene at a global level","volume":"110","author":"Pruss","year":"2002","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.femsim.2004.11.006-BIB48","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0020-7519(02)00248-5","article-title":"Successful vaccination of BALB\/c mice against human hookworm (Necator americanus): the immunological phenotype of the protective response","volume":"33","author":"Girod","year":"2003","journal-title":"Int. J. Parasitol."}],"container-title":["FEMS Immunology & Medical Microbiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/femspd\/article-pdf\/43\/2\/115\/19167569\/43-2-115.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,30]],"date-time":"2023-04-30T22:45:54Z","timestamp":1682894754000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/femspd\/article-lookup\/doi\/10.1016\/j.femsim.2004.11.006"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,2]]},"references-count":48,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2005,2]]}},"URL":"https:\/\/doi.org\/10.1016\/j.femsim.2004.11.006","relation":{},"ISSN":["0928-8244","1574-695X"],"issn-type":[{"value":"0928-8244","type":"print"},{"value":"1574-695X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,2]]}}}