{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T05:36:56Z","timestamp":1791351416791,"version":"4.3.1"},"reference-count":21,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2004,11,1]],"date-time":"2004-11-01T00:00:00Z","timestamp":1099267200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2004,11,1]],"date-time":"2004-11-01T00:00:00Z","timestamp":1099267200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,5,27]],"date-time":"2022-05-27T00:00:00Z","timestamp":1653609600000},"content-version":"vor","delay-in-days":6416,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","fertstert.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fertility and Sterility"],"published-print":{"date-parts":[[2004,11]]},"DOI":"10.1016\/j.fertnstert.2004.03.064","type":"journal-article","created":{"date-parts":[[2004,11,9]],"date-time":"2004-11-09T11:54:11Z","timestamp":1100001251000},"page":"1436-1439","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":76,"title":["Evaluation and treatment of familial globozoospermia in five brothers"],"prefix":"10.1016","volume":"82","author":[{"given":"Zaid","family":"Kilani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radwan","family":"Ismail","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samer","family":"Ghunaim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hossam","family":"Mohamed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Hughes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian","family":"Brewis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher L.R.","family":"Barratt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fertnstert.2004.03.064_bib1","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1093\/oxfordjournals.humrep.a136000","article-title":"Successful fertilization and establishment of pregnancies after intracytoplasmic sperm injection in patients with globoozospermia","volume":"10","author":"Liu","year":"1995","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2004.03.064_bib2","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.1093\/humrep\/13.8.2177","article-title":"Triplet pregnancy and delivery after intracytoplasmic injection of round headed sperm","volume":"13","author":"Kilani","year":"1998","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2004.03.064_bib3","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1093\/humrep\/15.1.139","article-title":"A normal live birth after intracytoplasmic sperm injection for globozoospermia without assisted oocyte activation","volume":"15","author":"Stone","year":"2000","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2004.03.064_bib4","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/S0015-0282(16)41900-X","article-title":"Round-headed human spermatozoa","volume":"27","author":"Anton-Lamprecht","year":"1976","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2004.03.064_bib5","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1016\/S0015-0282(01)02904-1","article-title":"Chromosome 15 aneuploidy in the sperm and conceptus of a sibling with variable familial expression of round-headed sperm syndrome","volume":"76","author":"Carrell","year":"2001","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2004.03.064_bib6","doi-asserted-by":"crossref","first-page":"2563","DOI":"10.1093\/humrep\/15.12.2563","article-title":"Do morphological anomalies reflect chromosomal aneuploidies?","volume":"12","author":"Viville","year":"2000","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2004.03.064_bib7","doi-asserted-by":"crossref","first-page":"2128","DOI":"10.1093\/humrep\/17.8.2128","article-title":"Globozoospermia is associated with chromatin structure abnormalities: case report","volume":"17","author":"Vicari","year":"2002","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2004.03.064_bib8","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1002\/j.1939-4640.2001.tb02198.x","article-title":"Chromatin structure in globozoospermia: a case report","volume":"22","author":"Larson","year":"2001","journal-title":"J Androl"},{"key":"10.1016\/j.fertnstert.2004.03.064_bib9","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/S0015-0282(16)53833-3","article-title":"Analysis of sperm function in globozoospermia: implications for the mechanism of sperm-zona interaction","volume":"54","author":"Aitken","year":"1990","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2004.03.064_bib10","series-title":"WHO laboratory manual for the examination of human semen and sperm-cervical mucus interaction","year":"1999"},{"key":"10.1016\/j.fertnstert.2004.03.064_bib11","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1002\/mrd.1120170308","article-title":"Visualization and characterization of the acrosome reaction of human spermatozoa by immunolocalization with monoclonal antibody","volume":"17","author":"Moore","year":"1987","journal-title":"Gamete Res"},{"key":"10.1016\/j.fertnstert.2004.03.064_bib12","series-title":"Practical methods in electron microscopy: fixation, dehydration and embedding of biological specimens","author":"Glauert","year":"1995"},{"key":"10.1016\/j.fertnstert.2004.03.064_bib13","doi-asserted-by":"crossref","first-page":"2119","DOI":"10.1093\/oxfordjournals.humrep.a137993","article-title":"Human blastocyst grading: an indicator of development potential?","volume":"8","author":"Dokras","year":"1993","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2004.03.064_bib14","first-page":"33","article-title":"On round-headed human spermatozoa","volume":"20","author":"Kullander","year":"1975","journal-title":"Int J Fertil"},{"key":"10.1016\/j.fertnstert.2004.03.064_bib15","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1111\/j.1439-0272.1978.tb03023.x","article-title":"Teratozoospermia absoluta de presentacion familiar","volume":"10","author":"Nistal","year":"1978","journal-title":"Andrologia"},{"key":"10.1016\/j.fertnstert.2004.03.064_bib16","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/j.1439-0272.1984.tb00262.x","article-title":"Biochemical and genetic investigation of round-headed spermatozoa in infertile men including two brothers and their father","volume":"16","author":"Florke-Gerloff","year":"1984","journal-title":"Andrologia"},{"key":"10.1016\/j.fertnstert.2004.03.064_bib17","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/S0015-0282(98)00498-1","article-title":"Characterisation of aneuploidy rates, protamine levels, ultrastructure, and functional ability of round-headed sperm from two siblings and implications for intracytoplasmic sperm injection","volume":"71","author":"Carrell","year":"1999","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2004.03.064_bib18","doi-asserted-by":"crossref","first-page":"3094","DOI":"10.1093\/humrep\/13.11.3094","article-title":"Cytogenetic analysis of unfertilized oocytes following intracytoplasmic sperm injection using spermatozoa from a globozoospermic man","volume":"13","author":"Edirisinghe","year":"1998","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2004.03.064_bib19","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1038\/12729","article-title":"Globozoospermia in mice lacking the casein kinase II catalytic subunit","volume":"23","author":"Xu","year":"1999","journal-title":"Nat Genet"},{"key":"10.1016\/j.fertnstert.2004.03.064_bib20","doi-asserted-by":"crossref","first-page":"11211","DOI":"10.1073\/pnas.162027899","article-title":"Lack of acrosome formation in mice lacking a Golgi protein, GOPC","volume":"99","author":"Yao","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.fertnstert.2004.03.064_bib21","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1126\/science.1063665","article-title":"Lack of acrosome formation in Hrb-deficient mice","volume":"294","author":"Kang-Decker","year":"2001","journal-title":"Science"}],"container-title":["Fertility and Sterility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028204022332?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028204022332?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T07:03:56Z","timestamp":1758006236000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0015028204022332"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,11]]},"references-count":21,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2004,11]]}},"alternative-id":["S0015028204022332"],"URL":"https:\/\/doi.org\/10.1016\/j.fertnstert.2004.03.064","relation":{},"ISSN":["0015-0282"],"issn-type":[{"value":"0015-0282","type":"print"}],"subject":[],"published":{"date-parts":[[2004,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Evaluation and treatment of familial globozoospermia in five brothers","name":"articletitle","label":"Article Title"},{"value":"Fertility and Sterility","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fertnstert.2004.03.064","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2004 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}