{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T19:51:18Z","timestamp":1777665078398,"version":"3.51.4"},"reference-count":76,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2005,3,1]],"date-time":"2005-03-01T00:00:00Z","timestamp":1109635200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2005,3,1]],"date-time":"2005-03-01T00:00:00Z","timestamp":1109635200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,5,27]],"date-time":"2022-05-27T00:00:00Z","timestamp":1653609600000},"content-version":"vor","delay-in-days":6296,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","fertstert.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fertility and Sterility"],"published-print":{"date-parts":[[2005,3]]},"DOI":"10.1016\/j.fertnstert.2004.07.976","type":"journal-article","created":{"date-parts":[[2005,3,5]],"date-time":"2005-03-05T07:11:39Z","timestamp":1110006699000},"page":"622-634","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"title":["Deletions in L-type calcium channel \u03b11 subunit testicular transcripts correlate with testicular cadmium and apoptosis in infertile men with varicoceles"],"prefix":"10.1016","volume":"83","author":[{"given":"Susan","family":"Benoff","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leslie O.","family":"Goodwin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Colleen","family":"Millan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian R.","family":"Hurley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert G.","family":"Pergolizzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joel L.","family":"Marmar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.fertnstert.2004.07.976_bib1","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1002\/j.1939-4640.1998.tb02053.x","article-title":"The emergence of specialized procedures for acquisition, processing and cryopreservation of epididymal and testicular sperm in connection with intracytoplasmic sperm injection","volume":"19","author":"Marmar","year":"1998","journal-title":"J Androl"},{"key":"10.1016\/j.fertnstert.2004.07.976_bib2","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1093\/humupd\/7.1.47","article-title":"Varicocele and male infertility: part I preface","volume":"7","author":"Benoff","year":"2001","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.fertnstert.2004.07.976_bib3","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1093\/humrep\/deh139","article-title":"Bilateral increased apoptosis and bilateral accumulation of cadmium in infertile men with left varicocele","volume":"19","author":"Benoff","year":"2004","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2004.07.976_bib4","doi-asserted-by":"crossref","first-page":"1952","DOI":"10.1016\/S0022-5347(01)65403-X","article-title":"Nitric oxide synthase and xanthine oxidase activities in the spermatic vein of patients with varicocele: a potential role for nitric oxide and peroxynitrite in sperm dysfunction","volume":"156","author":"Mitropoulos","year":"1996","journal-title":"J Urol"},{"key":"10.1016\/j.fertnstert.2004.07.976_bib5","first-page":"4154","article-title":"Evidence for production and functional activity of nitric oxide in seminiferous tubules and blood vessels of the human testis","volume":"82","author":"Middenddorff","year":"1997","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2004.07.976_bib6","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1053\/jpsu.2001.20724","article-title":"Nitric oxide production is increased in the spermatic veins of adolescents with left idiopathic varicocele","volume":"36","author":"Romeo","year":"2001","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.fertnstert.2004.07.976_bib7","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1046\/j.1464-4096.2001.02446.x","article-title":"Nitric oxide synthase patterns in normal and varicocele testis in adolescents","volume":"88","author":"Santoro","year":"2001","journal-title":"BJU Int"},{"key":"10.1016\/j.fertnstert.2004.07.976_bib8","doi-asserted-by":"crossref","first-page":"2604","DOI":"10.1073\/pnas.041359198","article-title":"Predominant role of endothelial nitric oxide synthase in vascular endothelial growth factor-induced angiogenesis and vascular permeability","volume":"98","author":"Fukumura","year":"2001","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.fertnstert.2004.07.976_bib9","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/s00240-003-0343-0","article-title":"Increased vasoconstrictor reactivity and decreased endothelial function in high grade varicocele: functional and morphological study","volume":"31","author":"Yildiz","year":"2003","journal-title":"Urol Res"},{"key":"10.1016\/j.fertnstert.2004.07.976_bib10","first-page":"686","article-title":"Acute cadmium intoxication","volume":"30","author":"Gabbiani","year":"1974","journal-title":"Lab Invest"},{"key":"10.1016\/j.fertnstert.2004.07.976_bib11","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1095\/biolreprod18.4.579","article-title":"Reexamination of the lesions in rat testis caused by cadmium","volume":"18","author":"Aoki","year":"1978","journal-title":"Biol Reprod"},{"key":"10.1016\/j.fertnstert.2004.07.976_bib12","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1111\/j.1439-0272.1988.tb01061.x","article-title":"The testes in cadmium intoxication: morphological and vascular aspects","volume":"20","author":"Gouveia","year":"1988","journal-title":"Andrologia"},{"key":"10.1016\/j.fertnstert.2004.07.976_bib13","doi-asserted-by":"crossref","first-page":"d1220","DOI":"10.2741\/A358","article-title":"Voltage-dependent calcium channels in spermatozoa","volume":"3","author":"Benoff","year":"1998","journal-title":"Front Biosci"},{"key":"10.1016\/j.fertnstert.2004.07.976_bib14","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1080\/1464727992000198311","article-title":"Receptors and channels regulating acrosome reactions","volume":"2","author":"Benoff","year":"1999","journal-title":"Hum Fertil"},{"key":"10.1016\/j.fertnstert.2004.07.976_bib15","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1093\/humupd\/6.2.107","article-title":"Male infertility and environmental exposure to lead and cadmium","volume":"6","author":"Benoff","year":"2000","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.fertnstert.2004.07.976_bib16","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1093\/molehr\/4.3.215","article-title":"Alternative splicing of exons in the \u03b11 subunit of the rat testis voltage-dependent calcium channel generates germ-line specific dihydropyridine binding sites","volume":"4","author":"Goodwin","year":"1998","journal-title":"Mol Hum Reprod"},{"key":"10.1016\/j.fertnstert.2004.07.976_bib17","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S0031-6997(25)06805-X","article-title":"Toxic effect of heavy metals on ion channels","volume":"46","author":"Kiss","year":"1994","journal-title":"Pharmacol Rev"},{"key":"10.1016\/j.fertnstert.2004.07.976_bib18","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1007\/BF02088688","article-title":"Combined actions of Pb2+, Zn2+, and Al3+ on voltage-activated calcium channel currents","volume":"14","author":"Platt","year":"1994","journal-title":"Cell Mol Neurobiol"},{"key":"10.1016\/j.fertnstert.2004.07.976_bib19","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1006\/dbio.1994.1242","article-title":"Sequential focal and global elevations of sperm intracellular Ca2+are initiated by the zona pellucida during acrosome exocytosis","volume":"165","author":"Florman","year":"1994","journal-title":"Dev Biol"},{"key":"10.1016\/j.fertnstert.2004.07.976_bib20","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/0012-1606(92)90137-6","article-title":"Activation of voltage-dependent calcium channels of mammalian sperm is required for zona pellucida-induced acrosomal exocytosis","volume":"152","author":"Florman","year":"1992","journal-title":"Dev Biol"},{"key":"10.1016\/j.fertnstert.2004.07.976_bib21","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/0300-483X(93)90073-2","article-title":"Stage-specific effects of cadmium on preimplantation embryo development and implantation in the mouse","volume":"80","author":"De","year":"1993","journal-title":"Toxicology"},{"key":"10.1016\/j.fertnstert.2004.07.976_bib22","doi-asserted-by":"crossref","first-page":"16333","DOI":"10.1016\/S0021-9258(18)49259-9","article-title":"Cadmium uptake and toxicity via voltage-sensitive calcium channels","volume":"262","author":"Hinkle","year":"1987","journal-title":"J Biol Chem"},{"key":"10.1016\/j.fertnstert.2004.07.976_bib23","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/S0041-008X(05)80018-3","article-title":"Differences in cadmium and mercury uptakes by hepatocytes: role of calcium channels","volume":"110","author":"Blazka","year":"1991","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1016\/j.fertnstert.2004.07.976_bib24","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S0300-483X(97)00057-7","article-title":"Cadmium uptake by a human hepatic cell line (WRL-68 cells)","volume":"120","author":"Souza","year":"1997","journal-title":"Toxicology"},{"key":"10.1016\/j.fertnstert.2004.07.976_bib25","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1007\/s002040050411","article-title":"Low levels of cadmium chloride damage the corneal endothelium","volume":"71","author":"Weidner","year":"1997","journal-title":"Arch Toxicol"},{"key":"10.1016\/j.fertnstert.2004.07.976_bib26","doi-asserted-by":"crossref","first-page":"39702","DOI":"10.1074\/jbc.M007369200","article-title":"Apoptosis induced by cadmium in human lymphoma U937 cells through Ca2+-calpain and caspase-mitochondria-dependent pathways","volume":"275","author":"Li","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1016\/j.fertnstert.2004.07.976_bib27","unstructured":"Goodwin LO, Leeds NB, Karabinus DS, Hurley IR, Pergolizzi RG, Benoff S. Variability in L-type voltage-dependent calcium channel (L-VDCC) sequence in human testis and sperm. [abstract No. O-062]. In: Programs and abstracts of the 55th Annual Meeting, American Society for Reproductive Medicine, 1999:S24."},{"key":"10.1016\/j.fertnstert.2004.07.976_bib28","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1146\/annurev.bi.64.070195.002425","article-title":"Structure and function of voltage-gated ion channels","volume":"64","author":"Catterall","year":"1995","journal-title":"Ann Rev Biochem"},{"key":"10.1016\/j.fertnstert.2004.07.976_bib29","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1126\/science.280.5360.69","article-title":"The structure of the potassium channel: molecular basis of K+ conduction and selectivity","volume":"280","author":"Doyle","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.fertnstert.2004.07.976_bib30","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1126\/science.1321496","article-title":"Molecular localization of an ion-binding site within the pore of mammalian sodium channels","volume":"257","author":"Backx","year":"1992","journal-title":"Science"},{"key":"10.1016\/j.fertnstert.2004.07.976_bib31","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1038\/356441a0","article-title":"Calcium channel characteristics conferred on the sodium channel by single mutations","volume":"356","author":"Heinemann","year":"1992","journal-title":"Nature"},{"key":"10.1016\/j.fertnstert.2004.07.976_bib32","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1126\/science.256.5060.1202","article-title":"A mutant of TTX-resistant sodium channels with TTX-sensitive properties","volume":"256","author":"Satin","year":"1992","journal-title":"Science"},{"key":"10.1016\/j.fertnstert.2004.07.976_bib33","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1038\/366158a0","article-title":"Zhang J-F, Tsien RW","volume":"336","author":"Yang","year":"1993","journal-title":"Nature"},{"key":"10.1016\/j.fertnstert.2004.07.976_bib34","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1038\/352800a0","article-title":"Repeat I of the dihydropyridine receptor is critical in determining calcium channel activation kinetics","volume":"352","author":"Tanabe","year":"1991","journal-title":"Nature"},{"key":"10.1016\/j.fertnstert.2004.07.976_bib35","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/372097a0","article-title":"Molecular determinants of voltage-dependent inactivation in calcium channels","volume":"372","author":"Zhang","year":"1994","journal-title":"Nature"},{"key":"10.1016\/j.fertnstert.2004.07.976_bib36","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0014-5793(99)01518-5","article-title":"Voltage-dependent Ca(2+) channel subunit expression and immunolocalization in mouse spermatogenic cells and sperm","volume":"464","author":"Serrano","year":"1999","journal-title":"FEBS Lett"},{"key":"10.1016\/j.fertnstert.2004.07.976_bib37","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1006\/dbio.1998.9172","article-title":"Discrete regional distributions suggest diverse functional roles of calcium channel alpha1 subunits in sperm","volume":"207","author":"Westenbroek","year":"1999","journal-title":"Dev Biol"},{"key":"10.1016\/j.fertnstert.2004.07.976_bib38","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1006\/geno.1994.1347","article-title":"Genomic structure of human L-type Ca2+ channel","volume":"22","author":"Soldatov","year":"1994","journal-title":"Genomics"},{"key":"10.1016\/j.fertnstert.2004.07.976_bib39","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1093\/molehr\/3.3.255","article-title":"Isolation and characterization of the primary structure of testis-specific calcium channel: implications for contraception","volume":"3","author":"Goodwin","year":"1997","journal-title":"Mol Hum Reprod"},{"key":"10.1016\/j.fertnstert.2004.07.976_bib40","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1016\/S0022-5347(17)32521-1","article-title":"Subinginual microsurgical varicocelectomy: a technical critique and statistical analysis of semen and pregnancy data","volume":"152","author":"Marmar","year":"1994","journal-title":"J Urol"},{"key":"10.1016\/j.fertnstert.2004.07.976_bib41","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1002\/j.1939-4640.1998.tb02053.x","article-title":"The emergence of specialized procedures for acquisition, processing and cryopreservation of epididymal and testicular sperm in connection with intracytoplasmic sperm injection","volume":"19","author":"Marmar","year":"1998","journal-title":"J Androl"},{"key":"10.1016\/j.fertnstert.2004.07.976_bib42","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1242\/jcs.111.9.1255","article-title":"Dynamic changes in the subnuclear organization of pre-mRNA splicing proteins and RBM during human germ cell development","volume":"111","author":"Elliott","year":"1998","journal-title":"J Cell Sci"},{"key":"10.1016\/j.fertnstert.2004.07.976_bib43","series-title":"Biostatistical analysis","author":"Zar","year":"1983"},{"key":"10.1016\/j.fertnstert.2004.07.976_bib44","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/S0090-4295(00)01015-3","article-title":"Response to varicocelectomy in oligospermic men with and without defined genetic infertility","volume":"57","author":"Cayan","year":"2001","journal-title":"Urology"},{"key":"10.1016\/j.fertnstert.2004.07.976_bib45","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1016\/S0022-5347(05)65192-0","article-title":"Can varicocelectomy significantly change the way couples use assisted reproductive technologies?","volume":"167","author":"Cayan","year":"2002","journal-title":"J Urol"},{"key":"10.1016\/j.fertnstert.2004.07.976_bib46","doi-asserted-by":"crossref","first-page":"2485","DOI":"10.1093\/nar\/13.7.2485","article-title":"Isolation and characterization of rat and human glyceraldehydes-3-phosphate dehydrogenase cDNAs: genomic complexity and molecular evolution of the gene","volume":"13","author":"Tso","year":"1985","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.fertnstert.2004.07.976_bib47","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1093\/molehr\/6.2.127","article-title":"L-type voltage-dependent calcium channel \u03b11C subunit mRNA is present in ejaculated human spermatozoa","volume":"6","author":"Goodwin","year":"2000","journal-title":"Mol Hum Reprod"},{"key":"10.1016\/j.fertnstert.2004.07.976_bib48","doi-asserted-by":"crossref","first-page":"3848","DOI":"10.1073\/pnas.94.8.3848","article-title":"Expression of RBM in the nuclei of human germ cells is dependent on a critical region of the Y chromosome long arm","volume":"94","author":"Elliott","year":"1997","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.fertnstert.2004.07.976_bib49","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/0022-1759(87)90214-6","article-title":"Quantitative differences among various proteins as blocking agents for ELISA microtitre plates","volume":"101","author":"Vogt","year":"1987","journal-title":"J Immunol Methods"},{"key":"10.1016\/j.fertnstert.2004.07.976_bib50","doi-asserted-by":"crossref","first-page":"7943","DOI":"10.1016\/S0021-9258(18)47507-2","article-title":"Structural characterization of the 1,4-dihydropyridine receptor of the voltage-dependent Ca2+ channel from rabbit skeletal muscle","volume":"262","author":"Leung","year":"1987","journal-title":"J Biol Chem"},{"key":"10.1016\/j.fertnstert.2004.07.976_bib51","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1002\/j.1939-4640.2000.tb03270.x","article-title":"Rationale, interpretation, validation, and uses of sperm function tests","volume":"21","author":"Muller","year":"2000","journal-title":"J Androl"},{"key":"10.1016\/j.fertnstert.2004.07.976_bib52","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1002\/ana.410420302","article-title":"Calcium channels in neurological disease","volume":"42","author":"Greenberg","year":"1997","journal-title":"Ann Neurol"},{"key":"10.1016\/j.fertnstert.2004.07.976_bib53","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1016\/S0140-6736(03)13503-9","article-title":"Assessment of efficacy of varicocele repair for male subfertility: a systematic review","volume":"361","author":"Evers","year":"2003","journal-title":"Lancet"},{"key":"10.1016\/j.fertnstert.2004.07.976_bib54","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1085\/jgp.98.4.751","article-title":"Cadmium block of squid calcium currents","volume":"98","author":"Chow","year":"1991","journal-title":"J Gen Physiol"},{"key":"10.1016\/j.fertnstert.2004.07.976_bib55","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1113\/jphysiol.1993.sp019738","article-title":"Ion permeation through L-type Ca2+ channel in rat phaeochromocytoma cells: two sets of ion binding sites in the pore","volume":"466","author":"Kuo","year":"1993","journal-title":"J Physiol"},{"key":"10.1016\/j.fertnstert.2004.07.976_bib56","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1113\/jphysiol.1993.sp019739","article-title":"Characterization of the high-affinity Ca2+ binding sites in the L-type Ca2+ channel pore in rat phaeochromocytoma cells","volume":"466","author":"Kuo","year":"1993","journal-title":"J Physiol"},{"key":"10.1016\/j.fertnstert.2004.07.976_bib57","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1085\/jgp.88.3.293","article-title":"Calcium channel selectivity for divalent and monovalent cations","volume":"88","author":"Hess","year":"1986","journal-title":"J Gen Physiol"},{"key":"10.1016\/j.fertnstert.2004.07.976_bib58","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1085\/jgp.88.3.321","article-title":"Blockade of current through single calcium channels by Cd2+, Mg2+ and Ca2+","volume":"88","author":"Lansman","year":"1986","journal-title":"J Gen Physiol"},{"key":"10.1016\/j.fertnstert.2004.07.976_bib59","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0143-4160(97)90088-9","article-title":"Novel variants of voltage-operated calcium channel alpha1-subunit transcripts in rat liver-derived cell line; deletions in the IVS4 voltage sensing region","volume":"22","author":"Brereton","year":"1997","journal-title":"Cell Calcium"},{"key":"10.1016\/j.fertnstert.2004.07.976_bib60","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1016\/0092-8674(94)90385-9","article-title":"The amino-terminal portion of CFTR forms a regulated Cl- channel","volume":"76","author":"Sheppard","year":"1994","journal-title":"Cell"},{"key":"10.1016\/j.fertnstert.2004.07.976_bib61","first-page":"571","article-title":"A patch clamp study on reconstituted calcium permeable channels of human sperm plasma membranes","volume":"51","author":"Ma","year":"1999","journal-title":"Sheng Li XueBao"},{"key":"10.1016\/j.fertnstert.2004.07.976_bib62","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/368067a0","article-title":"Calcium channel \u03b2-subunit binds to a conserved motif in the I-II cytoplasmic linker of the \u03b1 subunit","volume":"368;","author":"Pragnell","year":"1994","journal-title":"Nature"},{"key":"10.1016\/j.fertnstert.2004.07.976_bib63","doi-asserted-by":"crossref","first-page":"2137","DOI":"10.1074\/jbc.274.4.2137","article-title":"Complexes of the \u03b11c and \u03b2 subunits generate the necessary signal for membrane targeting of the class C L-type calcium channels","volume":"274","author":"Gao","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1016\/j.fertnstert.2004.07.976_bib64","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/S0022-5347(17)55945-5","article-title":"Venous tension patterns in cord veins","volume":"123","author":"Shafik","year":"1980","journal-title":"J Urol"},{"key":"10.1016\/j.fertnstert.2004.07.976_bib65","first-page":"H37","article-title":"Alteration of testicular microvascular pressures during venous pressure elevation","volume":"269","author":"Sweeney","year":"1995","journal-title":"Am J Physiol"},{"key":"10.1016\/j.fertnstert.2004.07.976_bib66","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/0896-6273(92)90204-Q","article-title":"A two-motif isoform of the major calcium channel subunit in skeletal muscle","volume":"8","author":"Malouf","year":"1992","journal-title":"Neuron"},{"key":"10.1016\/j.fertnstert.2004.07.976_bib67","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1074\/jbc.270.1.483","article-title":"Cloning and expression of a novel truncated calcium channel from non-excitable cells","volume":"270","author":"Ma","year":"1995","journal-title":"J Biol Chem"},{"key":"10.1016\/j.fertnstert.2004.07.976_bib68","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1096\/fj.00-0106com","article-title":"Calcium\/calmodulin-dependent protein kinase type IV (CaMKIV) inhibits apoptosis induced by potassium deprivation in cerebellar granule neurons","volume":"15","author":"See","year":"2001","journal-title":"FASEB J"},{"key":"10.1016\/j.fertnstert.2004.07.976_bib69","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1126\/science.7686306","article-title":"Increased activity of L-type Ca2+ channels exposed to serum from patients with type I diabetes","volume":"261","author":"Juntti-Berggren","year":"1993","journal-title":"Science"},{"key":"10.1016\/j.fertnstert.2004.07.976_bib70","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1161\/01.CIR.103.1.140","article-title":"A Ca2+-dependent transgenic model of cardiac hypertrophy","volume":"103","author":"Muth","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.fertnstert.2004.07.976_bib71","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1002\/pros.2990170302","article-title":"Role of calcium in the programmed cell death in rat ventral prostatic glandular cells","volume":"17","author":"Martikainen","year":"1990","journal-title":"Prostate"},{"key":"10.1016\/j.fertnstert.2004.07.976_bib72","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/S0022-5347(18)38625-7","article-title":"The role of testis biopsies in the work up of patients with varicoceles","volume":"171","author":"Marmar","year":"2004","journal-title":"J Urol"},{"key":"10.1016\/j.fertnstert.2004.07.976_bib73","unstructured":"Millan C, Hurley IR, Marmar JL, Benoff S. Can varicocelectomy outcome be altered by selective defects in testis L-type voltage-dependent calcium channels (L-VDCC)? In: Program and abstracts of the Twenty-Eighth Annual Meeting of the American Society of Andrology, 2003:P180."},{"key":"10.1016\/j.fertnstert.2004.07.976_bib74","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0169-328X(03)00083-4","article-title":"Selective decrease in NR1 subunit splice variant mRNA in the hippocampus of the Pb2+-exposed rats: implications for synaptic targeting and cell surface expression of NMDAR complexes","volume":"113","author":"Guilarte","year":"2003","journal-title":"Brain Res Mol Brain Res"},{"key":"10.1016\/j.fertnstert.2004.07.976_bib75","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/S0169-328X(00)00010-3","article-title":"Hippocampal expression of N-methyl-D-aspartate receptor (NMDAR1) subunit splice variant mRNA is altered by developmental exposure to Pb(2+)","volume":"76","author":"Guilarte","year":"2000","journal-title":"Brain Res Mol Brain Res"},{"key":"10.1016\/j.fertnstert.2004.07.976_bib76","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1006\/bbrc.1999.1879","article-title":"Calcium controls the transcription of it own transporters and channels in developing neurons","volume":"266","author":"Carafoli","year":"1999","journal-title":"Biochem Biophys Res Commun"}],"container-title":["Fertility and Sterility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028204030109?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028204030109?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T07:07:16Z","timestamp":1758006436000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0015028204030109"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,3]]},"references-count":76,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2005,3]]}},"alternative-id":["S0015028204030109"],"URL":"https:\/\/doi.org\/10.1016\/j.fertnstert.2004.07.976","relation":{},"ISSN":["0015-0282"],"issn-type":[{"value":"0015-0282","type":"print"}],"subject":[],"published":{"date-parts":[[2005,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Deletions in L-type calcium channel \u03b11 subunit testicular transcripts correlate with testicular cadmium and apoptosis in infertile men with varicoceles","name":"articletitle","label":"Article Title"},{"value":"Fertility and Sterility","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fertnstert.2004.07.976","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2005 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}