{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T01:20:05Z","timestamp":1771550405245,"version":"3.50.1"},"reference-count":44,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2005,3,1]],"date-time":"2005-03-01T00:00:00Z","timestamp":1109635200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2005,3,1]],"date-time":"2005-03-01T00:00:00Z","timestamp":1109635200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,5,27]],"date-time":"2022-05-27T00:00:00Z","timestamp":1653609600000},"content-version":"vor","delay-in-days":6296,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","fertstert.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fertility and Sterility"],"published-print":{"date-parts":[[2005,3]]},"DOI":"10.1016\/j.fertnstert.2004.10.030","type":"journal-article","created":{"date-parts":[[2005,3,5]],"date-time":"2005-03-05T07:11:39Z","timestamp":1110006699000},"page":"671-683","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":76,"title":["Risk factors for high-order multiple pregnancy and multiple birth after controlled ovarian hyperstimulation: Results of 4,062 intrauterine insemination cycles"],"prefix":"10.1016","volume":"83","author":[{"given":"Richard P.","family":"Dickey","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven N.","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter Y.","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Belinda M.","family":"Sartor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phillip H.","family":"Rye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roman","family":"Pyrzak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.fertnstert.2004.10.030_bib1","first-page":"1","article-title":"Trends in twin and triplet births: 1980\u20131997","volume":"47","author":"Martin","year":"1999","journal-title":"Vital Health Stat"},{"key":"10.1016\/j.fertnstert.2004.10.030_bib2","first-page":"1","article-title":"Births: final data for 2000","volume":"50","author":"Martin","year":"2002","journal-title":"Vital Health Stat"},{"key":"10.1016\/j.fertnstert.2004.10.030_bib3","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1542\/peds.111.S1.1159","article-title":"Trends in multiple births conceived using assisted reproductive technology, United States, 1997\u20132000","volume":"111","author":"Reynolds","year":"2003","journal-title":"Pediatrics"},{"key":"10.1016\/j.fertnstert.2004.10.030_bib4","doi-asserted-by":"crossref","unstructured":"Society for Assisted Reproductive Technology and the American Society for Reproductive Medicine. Assisted reproductive technology in the United States and Canada. 1998 results generated from The American Fertility Society\/Society of Assisted Reproductive Technology Registry. Fertil Steril 2002;77:18\u201331.","DOI":"10.1016\/S0015-0282(01)02985-5"},{"key":"10.1016\/j.fertnstert.2004.10.030_bib5","series-title":"2000 Assisted Reproductive Technology Society Rates","year":"2002"},{"key":"10.1016\/j.fertnstert.2004.10.030_bib6","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1007\/BF02069646","article-title":"Factors responsible for multiple pregnancies after ovarian stimulation and intrauterine insemination with gonadotropins","volume":"13","author":"Valbuena","year":"1996","journal-title":"J Assist Reprod Genet"},{"key":"10.1016\/j.fertnstert.2004.10.030_bib7","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1007\/BF02070144","article-title":"Success of intrauterine insemination using cryopreserved donor sperm is related to the age of the woman and the number of preovulatory follicles","volume":"13","author":"Pittrof","year":"1996","journal-title":"J Assist Reprod Genet"},{"key":"10.1016\/j.fertnstert.2004.10.030_bib8","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1093\/humrep\/12.9.1939","article-title":"Cumulative pregnancy rates in couples with anovulatory infertility compared with unexplained infertility in an ovulation induction program","volume":"12","author":"Takokoro","year":"1997","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2004.10.030_bib9","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1093\/oxfordjournals.humrep.a136822","article-title":"The treatment of infertility by the high intrauterine insemination of husband's washed spermatozoa","volume":"3","author":"Yovich","year":"1988","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2004.10.030_bib10","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1093\/oxfordjournals.humrep.a138096","article-title":"Homologous intrauterine insemination has no advantage over timed natural intercourse when used in combination with ovulation induction for the treatment of unexplained infertility","volume":"8","author":"Zikopoulos","year":"1993","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2004.10.030_bib11","doi-asserted-by":"crossref","first-page":"1892","DOI":"10.1093\/oxfordjournals.humrep.a019513","article-title":"Prognostic indicators for intrauterine insemination (IUI): statistical model for IUI success","volume":"11","author":"Tomlinson","year":"1996","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2004.10.030_bib12","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1093\/humrep\/13.6.1527","article-title":"A randomized controlled trial of three low-dose gonadotropins protocols for unexplained infertility","volume":"13","author":"Hughes","year":"1998","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2004.10.030_bib13","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1016\/S0015-0282(16)59583-1","article-title":"Active ovulation management increases the monthly probability of pregnancy occurrence in ovulatory women who receive intrauterine insemination","volume":"48","author":"Kemmann","year":"1987","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2004.10.030_bib14","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0015-0282(16)45308-2","article-title":"Multiple pregnancies following induction of ovulation","volume":"35","author":"Schenker","year":"1981","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2004.10.030_bib15","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1093\/oxfordjournals.humrep.a137012","article-title":"Intrauterine insemination and controlled ovarian hyperstimulation in cycles before GIFT","volume":"4","author":"Remohi","year":"1989","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2004.10.030_bib16","first-page":"658","article-title":"Treating infertility: controlled ovarian hyperstimulation using human menopausal gonadotropin in combination with intrauterine insemination","volume":"41","author":"Vollenhoven","year":"1996","journal-title":"J Reprod Med"},{"key":"10.1016\/j.fertnstert.2004.10.030_bib17","doi-asserted-by":"crossref","first-page":"2124","DOI":"10.1093\/humrep\/16.10.2124","article-title":"Risk factors for high-order multiple implantation after ovarian stimulation with gonadotropins: evidence from a large series of 1878 consecutive pregnancies in a single center","volume":"16","author":"Tur","year":"2001","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2004.10.030_bib18","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0015-0282(00)01631-9","article-title":"Relationship of follicle numbers and estradiol concentrations to multiple implantation of 3608 intrauterine insemination cycles","volume":"75","author":"Dickey","year":"2001","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2004.10.030_bib19","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1056\/NEJM200007063430101","article-title":"Reducing the risk of high-order multiple pregnancy after ovarian stimulation with gonadotropins","volume":"343","author":"Gleicher","year":"2000","journal-title":"N Engl J Med"},{"key":"10.1016\/j.fertnstert.2004.10.030_bib20","series-title":"Laboratory manual for the examination of human semen and semen cervical mucus interaction","year":"1993"},{"key":"10.1016\/j.fertnstert.2004.10.030_bib21","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/S0015-0282(16)46158-3","article-title":"Postcoital testing in women during menotropins therapy","volume":"37","author":"Skaf","year":"1982","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2004.10.030_bib22","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/S0015-0282(98)00519-6","article-title":"Comparison of sperm quality resulting in successful intrauterine insemination with world health organization criteria for normal sperm","volume":"71","author":"Dickey","year":"1999","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2004.10.030_bib23","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1016\/S0015-0282(16)48260-9","article-title":"Diagnosis-specific serum 17B-estradiol (E2) upper limits for treatment with menotropins using a 125I direct E2 assay","volume":"42","author":"Haning","year":"1984","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2004.10.030_bib24","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/S0015-0282(16)56276-1","article-title":"The inability of preovulatory ovarian scan to predict multifetal pregnancy occurrence in a follow-up of induction of ovulation with menotropins","volume":"60","author":"Ben-Nun","year":"1993","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2004.10.030_bib25","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1007\/BF02765776","article-title":"Evaluation of predictive factors for multiple pregnancies during gonadotropin\/IUI treatment","volume":"14","author":"Goldfarb","year":"1997","journal-title":"J Assist Reprod Genet"},{"key":"10.1016\/j.fertnstert.2004.10.030_bib26","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1093\/HUMREP\/11.2.429","article-title":"Treatment of anovulatory infertility: the problem of multiple pregnancy","volume":"11","author":"Farhi","year":"1996","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2004.10.030_bib27","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1067\/mob.2002.118915","article-title":"Spontaneous reduction of multiple pregnancy: incidence and effect on outcome","volume":"186","author":"Dickey","year":"2002","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.fertnstert.2004.10.030_bib28","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1093\/humupd\/8.5.449","article-title":"Ovulation induction in perspective","volume":"8","author":"Homburg","year":"2002","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.fertnstert.2004.10.030_bib29","doi-asserted-by":"crossref","first-page":"1081A","DOI":"10.1210\/jcem-71-5-1081","article-title":"Clinical review 15: management of ovulatory disorders with pulsatile gonadotropin-releasing hormone","volume":"71","author":"Martin","year":"1990","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2004.10.030_bib30","series-title":"Perganol (menotropins for injection USP) [Manufacturer's package insert]","year":"1969"},{"key":"10.1016\/j.fertnstert.2004.10.030_bib31","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.fertnstert.2003.07.031","article-title":"Clomiphene citrate intrauterine insemination (IUI) before gonadotropin IUI affects the pregnancy rate and high order multiple pregnancy","volume":"81","author":"Dickey","year":"2004","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2004.10.030_bib32","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1023\/A:1023000719569","article-title":"Low multiple pregnancy rates and reduced frequency of cancellation after ovulation induction with gonadotropins, if eventual supernumerary follicles are aspirated to prevent polyovulation","volume":"15","author":"De Geyter","year":"1998","journal-title":"J Assist Reprod Genet"},{"key":"10.1016\/j.fertnstert.2004.10.030_bib33","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/S0015-0282(16)54168-5","article-title":"Controlled ovarian hyperstimulation and intrauterine insemination for treatment of infertility","volume":"55","author":"Dodson","year":"1991","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2004.10.030_bib34","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/S0015-0282(99)00300-3","article-title":"Influence of age, diagnosis, and cycle number on pregnancy rates with gonadotropin-induced controlled ovarian hyperstimulation and intrauterine insemination","volume":"72","author":"Sahakyan","year":"1999","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2004.10.030_bib35","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1093\/oxfordjournals.humrep.a137467","article-title":"Multiple follicular recruitment and intrauterine insemination outcomes compared by age and diagnosis","volume":"6","author":"Horbay","year":"1991","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2004.10.030_bib36","doi-asserted-by":"crossref","first-page":"2110","DOI":"10.1093\/humrep\/13.8.2110","article-title":"Sequential clomiphene citrate and human menopausal gonadotropin with intrauterine insemination: the effect of patient age on clinical outcome","volume":"13","author":"Brzechffa","year":"1998","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2004.10.030_bib37","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1093\/humrep\/14.3.698","article-title":"Intrauterine insemination treatment in subfertility: an analysis of factors affecting outcome","volume":"14","author":"Nuojua-Huttunen","year":"1999","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2004.10.030_bib38","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1016\/S0015-0282(02)03343-5","article-title":"Cycle-specific and cumulative fecundity in patients with endometriosis who are undergoing controlled ovarian hyperstimulation-intrauterine insemination or in vitro fertilization-embryo transfer","volume":"78","author":"Dmowski","year":"2002","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2004.10.030_bib39","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/S0015-0282(16)54111-9","article-title":"A comparative analysis of the cycle fecundity rates associated with combined human menopausal gonadotropin and intrauterine insemination versus either hMG or IUI alone","volume":"55","author":"Chaffkin","year":"1991","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2004.10.030_bib40","doi-asserted-by":"crossref","first-page":"2014","DOI":"10.1093\/oxfordjournals.humrep.a138385","article-title":"Predicting and optimizing success in an intra-uterine insemination programme","volume":"9","author":"Plosker","year":"1994","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2004.10.030_bib41","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/S0015-0282(00)01641-1","article-title":"Controlled ovarian hyperstimulation and intrauterine insemination for treatment of unexplained infertility should be limited to a maximum of three trials","volume":"75","author":"Aboulghar","year":"2001","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2004.10.030_bib42","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/S0015-0282(97)81467-7","article-title":"Randomized controlled trial of superovulation and insemination for infertility associated with minimal or mild endometriosis","volume":"68","author":"Tummon","year":"1997","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2004.10.030_bib43","doi-asserted-by":"crossref","first-page":"3139","DOI":"10.1093\/oxfordjournals.humrep.a135875","article-title":"Randomized comparison of ovulation induction with or without intrauterine insemination in the treatment of unexplained infertility","volume":"10","author":"Chung","year":"1995","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2004.10.030_bib44","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/S0015-0282(97)81515-4","article-title":"Patient dropout in an assisted reproductive technology program: implications for pregnancy rates","volume":"68","author":"Land","year":"1997","journal-title":"Fertil Steril"}],"container-title":["Fertility and Sterility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028204030031?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028204030031?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T07:05:52Z","timestamp":1758006352000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0015028204030031"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,3]]},"references-count":44,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2005,3]]}},"alternative-id":["S0015028204030031"],"URL":"https:\/\/doi.org\/10.1016\/j.fertnstert.2004.10.030","relation":{},"ISSN":["0015-0282"],"issn-type":[{"value":"0015-0282","type":"print"}],"subject":[],"published":{"date-parts":[[2005,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Risk factors for high-order multiple pregnancy and multiple birth after controlled ovarian hyperstimulation: Results of 4,062 intrauterine insemination cycles","name":"articletitle","label":"Article Title"},{"value":"Fertility and Sterility","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fertnstert.2004.10.030","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2005 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}