{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T18:01:39Z","timestamp":1792692099309,"version":"4.5.0"},"reference-count":56,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2005,8,1]],"date-time":"2005-08-01T00:00:00Z","timestamp":1122854400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2005,8,1]],"date-time":"2005-08-01T00:00:00Z","timestamp":1122854400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,5,27]],"date-time":"2022-05-27T00:00:00Z","timestamp":1653609600000},"content-version":"vor","delay-in-days":6143,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","fertstert.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fertility and Sterility"],"published-print":{"date-parts":[[2005,8]]},"DOI":"10.1016\/j.fertnstert.2005.01.142","type":"journal-article","created":{"date-parts":[[2005,8,6]],"date-time":"2005-08-06T08:19:56Z","timestamp":1123316396000},"page":"474-484","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"title":["Expression profile of the tumorigenic factors associated with tumor size and sex steroid hormone status in uterine leiomyomata"],"prefix":"10.1016","volume":"84","author":[{"given":"Jian-Jun","family":"Wei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Chiriboga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khush","family":"Mittal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fertnstert.2005.01.142_bib1","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1093\/ajcp\/94.4.435","article-title":"The frequency of uterine leiomyomas","volume":"94","author":"Cramer","year":"1990","journal-title":"Am J Clin Pathol"},{"key":"10.1016\/j.fertnstert.2005.01.142_bib2","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/0002-9378(90)91195-I","article-title":"The impact of a quality assurance process on the frequency and confirmation rate of hysterectomy","volume":"163","author":"Gambone","year":"1990","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.fertnstert.2005.01.142_bib3","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1111\/j.1479-828X.2001.tb01231.x","article-title":"Ten-year review of hysterectomy morbidity and mortality","volume":"41","author":"Varol","year":"2001","journal-title":"Aust N Z J Obstet Gynaecol"},{"key":"10.1016\/j.fertnstert.2005.01.142_bib4","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1093\/humupd\/7.1.8","article-title":"Leiomyomata","volume":"7","author":"Ligon","year":"2001","journal-title":"Hum Reprod Update"},{"issue":"Suppl 5","key":"10.1016\/j.fertnstert.2005.01.142_bib5","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1289\/ehp.00108s5775","article-title":"Genetic approaches to the study of uterine leiomyomata","volume":"108","author":"Morton","year":"2000","journal-title":"Environ Health Perspect"},{"key":"10.1016\/j.fertnstert.2005.01.142_bib6","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1002\/gcc.10281","article-title":"Uterine leiomyoma in the Eker rat","volume":"38","author":"Walker","year":"2003","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1016\/j.fertnstert.2005.01.142_bib7","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1093\/humupd\/dmh019","article-title":"Sex steroidal regulation of uterine leiomyoma growth and apoptosis","volume":"10","author":"Maruo","year":"2004","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.fertnstert.2005.01.142_bib8","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1055\/s-2007-1016336","article-title":"Growth factors and cytokines in uterine leiomyomas","volume":"14","author":"Andersen","year":"1996","journal-title":"Semin Reprod Endocrinol"},{"key":"10.1016\/j.fertnstert.2005.01.142_bib9","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1002\/mrd.1080270203","article-title":"Expression of the insulin-like and platelet-derived growth factor genes in human uterine tissues","volume":"27","author":"Boehm","year":"1990","journal-title":"Mol Reprod Dev"},{"key":"10.1016\/j.fertnstert.2005.01.142_bib10","first-page":"3222","article-title":"Suppression of transforming growth factor-beta (TGF beta) and TGF beta receptor messenger ribonucleic acid and protein expression in leiomyomata in women receiving gonadotropin-releasing hormone agonist therapy","volume":"81","author":"Dou","year":"1996","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2005.01.142_bib11","doi-asserted-by":"crossref","first-page":"5593","DOI":"10.1210\/jcem.86.11.8008","article-title":"Upregulation by IGF-I of proliferating cell nuclear antigen and Bcl-2 protein expression in human uterine leiomyoma cells","volume":"86","author":"Gao","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2005.01.142_bib12","doi-asserted-by":"crossref","first-page":"L854","DOI":"10.1152\/ajplung.00291.2001","article-title":"Phosphatidylinositol 3-kinase but not tuberin is required for PDGF-induced cell migration","volume":"282","author":"Irani","year":"2002","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.fertnstert.2005.01.142_bib13","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1093\/molehr\/6.12.1093","article-title":"Localization of connective tissue growth factor in human uterine tissues","volume":"6","author":"Uzumcu","year":"2000","journal-title":"Mol Hum Reprod"},{"key":"10.1016\/j.fertnstert.2005.01.142_bib14","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1093\/humrep\/15.1.50","article-title":"Elevation of insulin-like growth factor-binding protein-1 mRNA expression following hormone replacement therapy","volume":"15","author":"Wang","year":"2000","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2005.01.142_bib15","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/0165-4608(91)90229-N","article-title":"Chromosome analysis of 96 uterine leiomyomas","volume":"55","author":"Pandis","year":"1991","journal-title":"Cancer Genet Cytogenet"},{"key":"10.1016\/j.fertnstert.2005.01.142_bib16","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1016\/S0029-7844(97)00534-6","article-title":"Variation in the incidence of uterine leiomyoma among premenopausal women by age and race","volume":"90","author":"Marshall","year":"1997","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.fertnstert.2005.01.142_bib17","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1289\/ehp.5787","article-title":"Etiology and pathogenesis of uterine leiomyomas","volume":"111","author":"Flake","year":"2003","journal-title":"Environ Health Perspect"},{"key":"10.1016\/j.fertnstert.2005.01.142_bib18","first-page":"1556","article-title":"Rodent model of reproductive tract leiomyomata. Clinical and pathological features","volume":"146","author":"Everitt","year":"1995","journal-title":"Am J Pathol"},{"key":"10.1016\/j.fertnstert.2005.01.142_bib19","first-page":"3766","article-title":"Aberrant expression of HMGA2 in uterine leiomyoma associated with loss of TSC2 tumor suppressor gene function","volume":"62","author":"Hunter","year":"2002","journal-title":"Cancer Res"},{"key":"10.1016\/j.fertnstert.2005.01.142_bib20","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0002-9440(10)63091-X","article-title":"Biallelic inactivation of fumarate hydratase (FH) occurs in nonsyndromic uterine leiomyomas but is rare in other tumors","volume":"164","author":"Lehtonen","year":"2004","journal-title":"Am J Pathol"},{"key":"10.1016\/j.fertnstert.2005.01.142_bib21","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1002\/(SICI)1098-2264(199908)25:4<316::AID-GCC2>3.0.CO;2-0","article-title":"HMGIC expression in human adult and fetal tissues and in uterine leiomyomata","volume":"25","author":"Gattas","year":"1999","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1016\/j.fertnstert.2005.01.142_bib22","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1038\/labinvest.3780040","article-title":"HMGI-C and HMGI(Y) immunoreactivity correlates with cytogenetic abnormalities in lipomas, pulmonary chondroid hamartomas, endometrial polyps, and uterine leiomyomas and is compatible with rearrangement of the HMGI-C and HMGI(Y) genes","volume":"80","author":"Tallini","year":"2000","journal-title":"Lab Invest"},{"key":"10.1016\/j.fertnstert.2005.01.142_bib23","first-page":"911","article-title":"HMGI(Y) expression in human uterine leiomyomata. Involvement of another high-mobility group architectural factor in a benign neoplasm","volume":"150","author":"Williams","year":"1997","journal-title":"Am J Pathol"},{"key":"10.1016\/j.fertnstert.2005.01.142_bib24","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1093\/molehr\/5.12.1150","article-title":"Chromosomal translocations affecting 12q14\u201315 but not deletions of the long arm of chromosome 7 associated with a growth advantage of uterine smooth muscle cells","volume":"5","author":"Hennig","year":"1999","journal-title":"Mol Hum Reprod"},{"key":"10.1016\/j.fertnstert.2005.01.142_bib25","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/S0022-2143(03)00007-6","article-title":"Differential gene expression in uterine leiomyoma","volume":"141","author":"Skubitz","year":"2003","journal-title":"J Lab Clin Med"},{"key":"10.1016\/j.fertnstert.2005.01.142_bib26","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/S0015-0282(02)03191-6","article-title":"Insights from gene arrays on the development and growth regulation of uterine leiomyomata","volume":"78","author":"Tsibris","year":"2002","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2005.01.142_bib27","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/S0015-0282(03)00953-1","article-title":"Strategy for elucidating differentially expressed genes in leiomyomata identified by microarray technology","volume":"80","author":"Catherino","year":"2003","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2005.01.142_bib28","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1111\/j.0959-9673.2003.00362.x","article-title":"Targeted cellular process profiling approach for uterine leiomyoma using cDNA microarray, proteomics and gene ontology analysis","volume":"84","author":"Ahn","year":"2003","journal-title":"Int J Exp Pathol"},{"key":"10.1016\/j.fertnstert.2005.01.142_bib29","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S1071-55760300004-2","article-title":"Gene expression profile of leiomyoma and myometrium and the effect of gonadotropin releasing hormone analogue therapy","volume":"10","author":"Chegini","year":"2003","journal-title":"J Soc Gynecol Investig"},{"key":"10.1016\/j.fertnstert.2005.01.142_bib30","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1002\/gcc.20018","article-title":"Molecular pathogenesis of uterine smooth muscle tumors from transcriptional profiling","volume":"40","author":"Quade","year":"2004","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1016\/j.fertnstert.2005.01.142_bib31","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/S0015-0282(03)00730-1","article-title":"Distinctive proliferative phase differences in gene expression in human myometrium and leiomyomata","volume":"80","author":"Wang","year":"2003","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2005.01.142_bib32","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1093\/molehr\/gag066","article-title":"Fibroids display an antiangiogenic gene expression profile when compared with adjacent myometrium","volume":"9","author":"Weston","year":"2003","journal-title":"Mol Hum Reprod"},{"key":"10.1016\/j.fertnstert.2005.01.142_bib33","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.fertnstert.2004.01.047","article-title":"Molecular characterization of uterine fibroids and its implication for underlying mechanisms of pathogenesis","volume":"82","author":"Hoffman","year":"2004","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2005.01.142_bib34","first-page":"826","article-title":"Large uterine myoma with erythropoietin messenger RNA and erythrocytosis","volume":"96","author":"Kohama","year":"2000","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.fertnstert.2005.01.142_bib35","doi-asserted-by":"crossref","unstructured":"Wei J, Chiriboga L, Mizuguchi M, Yee H, Mittal K. Expression profile of tuberin and some potential tumorigenic factors in 60 patients with uterine leiomyomata. Mod Pathol 2004.","DOI":"10.1038\/modpathol.3800283"},{"key":"10.1016\/j.fertnstert.2005.01.142_bib36","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1046\/j.0305-1846.2001.00302.x","article-title":"Mutational analysis of TSC1 and TSC2 genes in gangliogliomas","volume":"27","author":"Becker","year":"2001","journal-title":"Neuropathol Appl Neurobiol"},{"key":"10.1016\/j.fertnstert.2005.01.142_bib37","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1007\/s004010050746","article-title":"Tuberin immunohistochemistry in brain, kidneys and heart with or without tuberous sclerosis","volume":"94","author":"Mizuguchi","year":"1997","journal-title":"Acta Neuropathol (Berl)"},{"key":"10.1016\/j.fertnstert.2005.01.142_bib38","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1002\/ana.410400621","article-title":"Loss of tuberin from cerebral tissues with tuberous sclerosis and astrocytoma","volume":"40","author":"Mizuguchi","year":"1996","journal-title":"Ann Neurol"},{"key":"10.1016\/j.fertnstert.2005.01.142_bib39","doi-asserted-by":"crossref","first-page":"2844","DOI":"10.1093\/humrep\/14.11.2844","article-title":"Immunohistochemical study of the proliferation index, oestrogen receptors and progesterone receptors A and B in leiomyomata and normal myometrium during the menstrual cycle and under gonadotrophin-releasing hormone agonist therapy","volume":"14","author":"Nisolle","year":"1999","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2005.01.142_bib40","doi-asserted-by":"crossref","first-page":"14863","DOI":"10.1073\/pnas.95.25.14863","article-title":"Cluster analysis and display of genome-wide expression patterns","volume":"95","author":"Eisen","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.fertnstert.2005.01.142_bib41","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1016\/S0002-9440(10)64434-3","article-title":"Software tools for high-throughput analysis and archiving of immunohistochemistry staining data obtained with tissue microarrays","volume":"161","author":"Liu","year":"2002","journal-title":"Am J Pathol"},{"key":"10.1016\/j.fertnstert.2005.01.142_bib42","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1093\/molehr\/7.11.1085","article-title":"Comparative analysis of cyclin D1 and oestrogen receptor (alpha and beta) levels in human leiomyoma and adjacent myometrium","volume":"7","author":"Kovacs","year":"2001","journal-title":"Mol Hum Reprod"},{"key":"10.1016\/j.fertnstert.2005.01.142_bib43","first-page":"969","article-title":"Adenomyosis","volume":"81","author":"Thomas","year":"1989","journal-title":"J Natl Med Assoc"},{"key":"10.1016\/j.fertnstert.2005.01.142_bib44","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1097\/01.pgp.0000101142.79462.be","article-title":"Incidental findings in uterine prolapse specimen","volume":"23","author":"Yin","year":"2004","journal-title":"Int J Gynecol Pathol"},{"key":"10.1016\/j.fertnstert.2005.01.142_bib45","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1038\/nm0798-844","article-title":"Tissue microarrays for high-throughput molecular profiling of tumor specimens","volume":"4","author":"Kononen","year":"1998","journal-title":"Nat Med"},{"key":"10.1016\/j.fertnstert.2005.01.142_bib46","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.1093\/jnci\/91.20.1758","article-title":"Hormone therapy failure in human prostate cancer","volume":"91","author":"Bubendorf","year":"1999","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.fertnstert.2005.01.142_bib47","doi-asserted-by":"crossref","first-page":"1943","DOI":"10.1038\/labinvest.3780204","article-title":"Validation of tissue microarray technology in breast carcinoma","volume":"80","author":"Camp","year":"2000","journal-title":"Lab Invest"},{"key":"10.1016\/j.fertnstert.2005.01.142_bib48","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1002\/1096-9896(200107)194:3<349::AID-PATH887>3.0.CO;2-D","article-title":"Microarrays of bladder cancer tissue are highly representative of proliferation index and histological grade","volume":"194","author":"Nocito","year":"2001","journal-title":"J Pathol"},{"key":"10.1016\/j.fertnstert.2005.01.142_bib49","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1093\/humrep\/12.4.815","article-title":"Distribution of the A and B forms of the progesterone receptor messenger ribonucleic acid and protein in uterine leiomyomata and adjacent myometrium","volume":"12","author":"Viville","year":"1997","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2005.01.142_bib50","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1002\/gcc.20035","article-title":"Reduced dermatopontin expression is a molecular link between uterine leiomyomas and keloids","volume":"40","author":"Catherino","year":"2004","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1016\/j.fertnstert.2005.01.142_bib51","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1093\/molehr\/4.1.83","article-title":"Cytogenetic abnormalities in uterine myomas are associated with myoma size","volume":"4","author":"Rein","year":"1998","journal-title":"Mol Hum Reprod"},{"key":"10.1016\/j.fertnstert.2005.01.142_bib52","first-page":"69","article-title":"The del(7q) subgroup in uterine leiomyomata","volume":"98","author":"Xing","year":"1997","journal-title":"Further evidence for the secondary nature of cytogenetic abnormalities in the pathobiology of uterine leiomyomata. Cancer Genet Cytogenet"},{"key":"10.1016\/j.fertnstert.2005.01.142_bib53","doi-asserted-by":"crossref","first-page":"20535","DOI":"10.1074\/jbc.273.32.20535","article-title":"Tuberous sclerosis gene 2 product modulates transcription mediated by steroid hormone receptor family members","volume":"273","author":"Henry","year":"1998","journal-title":"J Biol Chem"},{"key":"10.1016\/j.fertnstert.2005.01.142_bib54","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1097\/01.MP.0000024146.29531.5B","article-title":"Altered cellular distribution of tuberin and glucocorticoid receptor in sporadic fundic gland polyps","volume":"15","author":"Wei","year":"2002","journal-title":"Mod Pathol"},{"key":"10.1016\/j.fertnstert.2005.01.142_bib55","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/S0002-9440(10)61733-6","article-title":"Adenomyosis\u2014a result of disordered stromal differentiation","volume":"159","author":"Parrott","year":"2001","journal-title":"Am J Pathol"},{"key":"10.1016\/j.fertnstert.2005.01.142_bib56","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1093\/oxfordjournals.humrep.a138484","article-title":"Messenger RNA encoding the insulin-like growth factors and their binding proteins, in women with fibroids, pretreated with luteinizing hormone-releasing hormone agonists","volume":"9","author":"Vollenhoven","year":"1994","journal-title":"Hum Reprod"}],"container-title":["Fertility and Sterility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028205010216?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028205010216?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T07:08:22Z","timestamp":1758006502000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0015028205010216"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,8]]},"references-count":56,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2005,8]]}},"alternative-id":["S0015028205010216"],"URL":"https:\/\/doi.org\/10.1016\/j.fertnstert.2005.01.142","relation":{},"ISSN":["0015-0282"],"issn-type":[{"value":"0015-0282","type":"print"}],"subject":[],"published":{"date-parts":[[2005,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Expression profile of the tumorigenic factors associated with tumor size and sex steroid hormone status in uterine leiomyomata","name":"articletitle","label":"Article Title"},{"value":"Fertility and Sterility","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fertnstert.2005.01.142","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2005 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}