{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T15:49:08Z","timestamp":1775058548817,"version":"3.50.1"},"reference-count":41,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2005,12,1]],"date-time":"2005-12-01T00:00:00Z","timestamp":1133395200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2005,12,1]],"date-time":"2005-12-01T00:00:00Z","timestamp":1133395200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,5,27]],"date-time":"2022-05-27T00:00:00Z","timestamp":1653609600000},"content-version":"vor","delay-in-days":6021,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","fertstert.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fertility and Sterility"],"published-print":{"date-parts":[[2005,12]]},"DOI":"10.1016\/j.fertnstert.2005.05.051","type":"journal-article","created":{"date-parts":[[2005,12,16]],"date-time":"2005-12-16T10:08:10Z","timestamp":1134727690000},"page":"1693-1697","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"title":["Comparison of the clinical efficacy of flutamide and spironolactone plus Diane 35 in the treatment of idiopathic hirsutism: a randomized controlled study"],"prefix":"10.1016","volume":"84","author":[{"given":"M. Murat","family":"Inal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusuf","family":"Yildirim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. Eftal","family":"Taner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.fertnstert.2005.05.051_bib1","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/S0889-8545(05)70156-X","article-title":"New treatments of hyperandrogenism and hirsutism","volume":"27","author":"Hock","year":"2000","journal-title":"Obstet Gynecol Clin North Am"},{"key":"10.1016\/j.fertnstert.2005.05.051_bib2","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1055\/s-2003-43306","article-title":"The diagnosis and management of hirsutism","volume":"21","author":"Neithardt","year":"2003","journal-title":"Semin Reprod Med"},{"key":"10.1016\/j.fertnstert.2005.05.051_bib3","first-page":"995","article-title":"The evaluation and management of hirsutism","volume":"101","author":"Azziz","year":"2003","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.fertnstert.2005.05.051_bib4","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1530\/eje.0.1390421","article-title":"Prevalence of idiopathic hirsutism","volume":"139","author":"Carmina","year":"1998","journal-title":"Eur J Endocrinol"},{"key":"10.1016\/j.fertnstert.2005.05.051_bib5","first-page":"354","article-title":"Should androgen levels be measured in hirsute women with normal menstrual cycles?","volume":"37","author":"Mehta","year":"1992","journal-title":"Int J Fertil"},{"key":"10.1016\/j.fertnstert.2005.05.051_bib6","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/S0015-0282(98)00141-1","article-title":"Idiopathic hirsutism","volume":"70","author":"Azziz","year":"1998","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2005.05.051_bib7","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/S0015-0282(16)48320-2","article-title":"Increased 5 alpha-reductase activity in idiopathic hirsutism","volume":"43","author":"Serafini","year":"1985","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2005.05.051_bib8","first-page":"774","article-title":"Insulin resistance and the polycystic ovary syndrome","volume":"18","author":"Dunaif","year":"1997","journal-title":"Endocrinol Rev"},{"key":"10.1016\/j.fertnstert.2005.05.051_bib9","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/S0015-0282(99)00275-7","article-title":"Treatment with flutamide improves hyperinsulinemia in women with idiopathic hirsutism","volume":"72","author":"Paoletti","year":"1999","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2005.05.051_bib10","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1210\/endo-116-1-226","article-title":"Effect of a nonsteroidal antiandrogen flutamide on androgen receptor dynamics and ornithine decarboxylase gene expression in mouse kidney","volume":"116","author":"Kontula","year":"1983","journal-title":"Endocrinology"},{"key":"10.1016\/j.fertnstert.2005.05.051_bib11","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/S0015-0282(16)58442-8","article-title":"The efficacy of 250 mg\/day flutamide in the treatment of patients with hirsutism","volume":"66","author":"Muderris","year":"1996","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2005.05.051_bib12","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/0020-7292(91)90772-W","article-title":"Flutamide in the treatment of hirsutism","volume":"36","author":"Motta","year":"1991","journal-title":"Int J Gynecol Obstet"},{"key":"10.1016\/j.fertnstert.2005.05.051_bib13","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1111\/j.1365-2265.1995.tb02922.x","article-title":"Clinical efficacy and safety of low dose flutamide alone and combined with an oral contraceptive for the treatment of idiopathic hirsutism","volume":"43","author":"Dodin","year":"1995","journal-title":"Clin Endocrinol"},{"key":"10.1016\/j.fertnstert.2005.05.051_bib14","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1111\/j.1365-2265.1993.tb01768.x","article-title":"The impact of a pure antiandrogen (flutamide) on LH, FSH, androgens and clinical status in idiopathic hirsutism","volume":"39","author":"Couzinet","year":"1993","journal-title":"Clin Endocrinol"},{"key":"10.1016\/j.fertnstert.2005.05.051_bib15","first-page":"507","article-title":"Biological and clinical properties of antiandrogens","volume":"31","author":"Neri","year":"1984","journal-title":"Prog Canc Res Ther"},{"key":"10.1016\/j.fertnstert.2005.05.051_bib16","first-page":"427","article-title":"A biological profile of a nonsteroidal antiandrogen SCN 13; 2104 nitro 3, trifluorometnyl-ovryronilide","volume":"91","author":"Nevi","year":"1972","journal-title":"Endocrinology"},{"key":"10.1016\/j.fertnstert.2005.05.051_bib17","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/0022-4731(87)90122-1","article-title":"Inhibition of rat testicular 17-\u03b1-hydroxylase and 17,20 lyase activites by antiandrogens (flutamide, hydroxyrlutamide, RV 23905, cyproterone acetate) in vitro","volume":"28","author":"Ayub","year":"1987","journal-title":"J Steroid Biochem"},{"key":"10.1016\/j.fertnstert.2005.05.051_bib18","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/0022-4731(87)90388-8","article-title":"Effects of flutamide and aminoglutethimide on plasma 5-\u03b1-reduced steroid glucouronide concentrations in castrated patients with cancer of the prostate","volume":"28","author":"Brochu","year":"1987","journal-title":"J Steroid Biochem"},{"key":"10.1016\/j.fertnstert.2005.05.051_bib19","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/S0015-0282(16)57785-1","article-title":"Flutamide in the treatment of hirsutism","volume":"64","author":"Moghetti","year":"1995","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2005.05.051_bib20","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1016\/S0015-0282(16)56280-3","article-title":"Clinical and endocrine effects of flutamide in hyperandrogenic women","volume":"60","author":"Fruzzetti","year":"1993","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2005.05.051_bib21","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0015-0282(16)56518-2","article-title":"Comparison of flutamide and spironolactone in the treatment of hirsutism","volume":"61","author":"Cusan","year":"1994","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2005.05.051_bib22","first-page":"45","article-title":"Managing patient with hirsutism","volume":"34","author":"Mercurio","year":"1998","journal-title":"Hosp Med"},{"key":"10.1016\/j.fertnstert.2005.05.051_bib23","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1007\/BF03348960","article-title":"Hirsutism and the effectiveness of spironolactone in its management","volume":"16","author":"McMullen","year":"1993","journal-title":"J Endocrinol Invest"},{"key":"10.1016\/j.fertnstert.2005.05.051_bib24","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1001\/jama.1982.03320340049034","article-title":"Treatment of hirsutism with spironolactone","volume":"247","author":"Cumming","year":"1982","journal-title":"JAMA"},{"key":"10.1016\/j.fertnstert.2005.05.051_bib25","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1210\/edrv-5-4-498","article-title":"Female hirsutism pathophysiological considerations and therapeutic implications","volume":"5","author":"Biffignandi","year":"1984","journal-title":"Endocrinol Rev"},{"key":"10.1016\/j.fertnstert.2005.05.051_bib26","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/S0015-0282(16)48373-1","article-title":"The effects of two doses of spironolactone on serum androgens and anagen hair in hirsute women","volume":"43","author":"Lobo","year":"1985","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2005.05.051_bib27","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/S0015-0282(16)49873-0","article-title":"Clinical efficacy and safety of cyproterone acetate in severe hirsutism","volume":"46","author":"Belisle","year":"1986","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2005.05.051_bib28","first-page":"29","article-title":"Contraceptive and therapeutic effectiveness of two low-dose ethinylestradiol and cyproterone acetate regimens in the treatment of hirsute patients","volume":"3","author":"Venturoli","year":"1998","journal-title":"Eur J Contrac Reprod Health Care"},{"key":"10.1016\/j.fertnstert.2005.05.051_bib29","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/0002-9378(81)90746-8","article-title":"Hirsutism","volume":"140","author":"Hatch","year":"1981","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.fertnstert.2005.05.051_bib30","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/S0015-0282(98)00486-5","article-title":"Treatment of hirsutism","volume":"71","author":"Fruzzetti","year":"1999","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2005.05.051_bib31","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0015-0282(99)00183-1","article-title":"Comparison of finasteride and flutamide in the treatment of idiopathic hirsutism","volume":"72","author":"Falsetti","year":"1999","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2005.05.051_bib32","first-page":"89","article-title":"Comparison of spironolactone, flutamide, and finasteride efficacy in the treatment of hirsutism","volume":"85","author":"Moghetti","year":"2000","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2005.05.051_bib33","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1046\/j.1365-2265.2000.00982.x","article-title":"Spironolactone as a single agent for long-term therapy of hirsute patients","volume":"52","author":"Spritzer","year":"2000","journal-title":"Clin Endocrinol"},{"key":"10.1016\/j.fertnstert.2005.05.051_bib34","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1530\/eje.0.1500351","article-title":"A comparison between spironolactone and spironolactone plus finasteride in the treatment of hirsutism","volume":"150","author":"Kelestimur","year":"2004","journal-title":"Eur J Endocrinol"},{"key":"10.1016\/j.fertnstert.2005.05.051_bib35","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1016\/S0015-0282(02)04927-0","article-title":"Use of cyproterone acetate, finasteride, and spironolactone to treat idiopathic hirsutism","volume":"79","author":"Lumachi","year":"2003","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2005.05.051_bib36","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.ijgo.2004.06.003","article-title":"Finasteride versus cyproterone acetate-estrogen regimens in the treatment of hirsutism","volume":"87","author":"Beigi","year":"2004","journal-title":"Int J Gynaecol Obstet"},{"key":"10.1016\/j.fertnstert.2005.05.051_bib37","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1016\/S0015-0282(99)00633-0","article-title":"Comparison of Diane 35 and Diane 35 plus finasteride in the treatment of hirsutism","volume":"73","author":"Tartagni","year":"2000","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2005.05.051_bib38","doi-asserted-by":"crossref","first-page":"89","DOI":"10.2165\/00128071-200001020-00003","article-title":"Management of hirsutism","volume":"1","author":"Falsetti","year":"2000","journal-title":"Am J Clin Dermatol"},{"key":"10.1016\/j.fertnstert.2005.05.051_bib39","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1055\/s-2007-1021407","article-title":"The treatment of hyperandrogenism with oral contraceptives","volume":"7","author":"Azziz","year":"1989","journal-title":"Semin Reprod Endocrinol"},{"key":"10.1016\/j.fertnstert.2005.05.051_bib40","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/0002-9343(92)90741-S","article-title":"Incidence of liver toxicity associated with the use of flutamide in prostate cancer patients","volume":"92","author":"Gomez","year":"1992","journal-title":"Am J Med"},{"key":"10.1016\/j.fertnstert.2005.05.051_bib41","doi-asserted-by":"crossref","first-page":"860","DOI":"10.7326\/0003-4819-118-11-199306010-00006","article-title":"Fatal and nonfatal hepatotoxicity associated with flutamide","volume":"118","author":"Wysowski","year":"1993","journal-title":"Ann Intern Med"}],"container-title":["Fertility and Sterility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028205029389?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028205029389?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T07:09:58Z","timestamp":1758006598000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0015028205029389"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,12]]},"references-count":41,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2005,12]]}},"alternative-id":["S0015028205029389"],"URL":"https:\/\/doi.org\/10.1016\/j.fertnstert.2005.05.051","relation":{},"ISSN":["0015-0282"],"issn-type":[{"value":"0015-0282","type":"print"}],"subject":[],"published":{"date-parts":[[2005,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comparison of the clinical efficacy of flutamide and spironolactone plus Diane 35 in the treatment of idiopathic hirsutism: a randomized controlled study","name":"articletitle","label":"Article Title"},{"value":"Fertility and Sterility","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fertnstert.2005.05.051","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2005 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}