{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T07:52:11Z","timestamp":1771487531215,"version":"3.50.1"},"reference-count":43,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2006,2,1]],"date-time":"2006-02-01T00:00:00Z","timestamp":1138752000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,2,1]],"date-time":"2006-02-01T00:00:00Z","timestamp":1138752000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,5,27]],"date-time":"2022-05-27T00:00:00Z","timestamp":1653609600000},"content-version":"vor","delay-in-days":5959,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","fertstert.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fertility and Sterility"],"published-print":{"date-parts":[[2006,2]]},"DOI":"10.1016\/j.fertnstert.2005.10.014","type":"journal-article","created":{"date-parts":[[2006,2,4]],"date-time":"2006-02-04T10:29:26Z","timestamp":1139048966000},"page":"326-332","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":123,"title":["Preimplantation genetic diagnosis significantly reduces pregnancy loss in infertile couples: a multicenter study"],"prefix":"10.1016","volume":"85","author":[{"given":"Santiago","family":"Munn\u00e9","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jill","family":"Fischer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alison","family":"Warner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serena","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christo","family":"Zouves","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacques","family":"Cohen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.fertnstert.2005.10.014_bib1","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1136\/bmj.299.6698.541","article-title":"Influence of past reproductive performance on risk of spontaneous abortion","volume":"299","author":"Regan","year":"1989","journal-title":"Br Med J"},{"key":"10.1016\/j.fertnstert.2005.10.014_bib2","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1056\/NEJM199510123331501","article-title":"Increased maternal age and the risk of fetal death","volume":"333","author":"Fretts","year":"1995","journal-title":"N Engl J Med"},{"key":"10.1016\/j.fertnstert.2005.10.014_bib3","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1136\/bmj.320.7251.1708","article-title":"Maternal age and fetal loss","volume":"320","author":"Nybo","year":"2000","journal-title":"Br Med J"},{"key":"10.1016\/j.fertnstert.2005.10.014_bib4","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1093\/humrep\/17.6.1649","article-title":"Paternal age and maternal age are risk factors for miscarriage; results of a multicentre European study","volume":"17","author":"La Rochebrochard","year":"2000","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2005.10.014_bib5","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/S1472-6483(10)60916-9","article-title":"Previous miscarriages influence IVF and intracytoplasmic sperm injection pregnancy outcome","volume":"8","author":"Kupka","year":"2004","journal-title":"Reprod Biomed Online"},{"key":"10.1016\/j.fertnstert.2005.10.014_bib6","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1093\/humrep\/deh078","article-title":"Incidence of spontaneous abortion among pregnancies produced by assisted reproductive technology","volume":"19","author":"Wang","year":"2004","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2005.10.014_bib7","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1016\/S0015-0282(02)04198-5","article-title":"Assisted reproductive technology in the United States","volume":"78","year":"2002","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2005.10.014_bib8","series-title":"Human genetics","first-page":"233","article-title":"Chromosome abnormalities","author":"Jacobs","year":"1987"},{"key":"10.1016\/j.fertnstert.2005.10.014_bib9","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1016\/S0015-0282(00)01801-X","article-title":"Karyotype of the abortuses in recurrent miscarriages","volume":"75","author":"Carp","year":"2001","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2005.10.014_bib10","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/S0015-0282(99)00495-1","article-title":"Embryonic karyotype of abortuses in relation to the number of previous miscarriages","volume":"73","author":"Ogasawara","year":"2000","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2005.10.014_bib11","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1093\/humrep\/17.2.446","article-title":"Cytogenetic analysis of miscarriages from couples with recurrent miscarriage","volume":"17","author":"Stephenson","year":"2002","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2005.10.014_bib12","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/S0015-0282(16)58079-0","article-title":"Frequency of abnormal karyotype among abortuses from women with and without a history of recurrent spontaneous abortions","volume":"65","author":"Stern","year":"1996","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2005.10.014_bib13","series-title":"Perinatal genetics","first-page":"133","article-title":"Cytogenetic abnormalities in spontaneous abortions of recognized conceptions","author":"Warburton","year":"1986"},{"key":"10.1016\/j.fertnstert.2005.10.014_bib14","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/S0015-0282(98)00445-2","article-title":"Cytogenetic diagnosis of \u201cnormal 46,XX\u201d karyotypes in spontaneous abortions frequently may be misleading","volume":"71","author":"Bell","year":"1999","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2005.10.014_bib15","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1159\/000015557","article-title":"Cytogenetics and mechanisms of spontaneous abortions","volume":"88","author":"Qumsiyeh","year":"2000","journal-title":"Cytogenet Cell Genet"},{"key":"10.1016\/j.fertnstert.2005.10.014_bib16","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1016\/j.fertnstert.2003.09.057","article-title":"Relationship between maternal age and aneuploidy in in-vitro fertilization pregnancy loss","volume":"81","author":"Spandorfer","year":"2004","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2005.10.014_bib17","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.1093\/humrep\/14.9.2191","article-title":"Positive outcome after preimplantation diagnosis of aneuploidy in human embryos","volume":"14","author":"Munn\u00e9","year":"1999","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2005.10.014_bib18","doi-asserted-by":"crossref","first-page":"S13","DOI":"10.1016\/S0303-7207(01)00570-6","article-title":"The in vivo and in vitro efficiency and efficacy of PGD for aneuploidy","volume":"183","author":"Gianaroli","year":"2001","journal-title":"Mol Cell Endocrinol"},{"key":"10.1016\/j.fertnstert.2005.10.014_bib19","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1093\/humrep\/17.5.1166","article-title":"Multiplex interphase FISH as a screen for common aneuploidies in spontaneous abortions","volume":"17","author":"Jobanputra","year":"2002","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2005.10.014_bib20","series-title":"A color atlas of human assisted reproduction","first-page":"179","article-title":"Polar body biopsy, embryo biopsy and fixation for FISH analysis","author":"Munn\u00e9","year":"2003"},{"key":"10.1016\/j.fertnstert.2005.10.014_bib21","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1093\/molehr\/4.9.863","article-title":"Scoring criteria for preimplantation genetic diagnosis of numerical abnormalities for chromosomes X, Y, 13, 16, 18 and 21","volume":"4","author":"Munn\u00e9","year":"1998","journal-title":"Mol Hum Reprod"},{"key":"10.1016\/j.fertnstert.2005.10.014_bib22","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/BF02072537","article-title":"Reduction in signal overlap results in increased FISH efficiency","volume":"13","author":"Munn\u00e9","year":"1996","journal-title":"J Assist Reprod Genet"},{"key":"10.1016\/j.fertnstert.2005.10.014_bib23","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/S1472-6483(10)61808-1","article-title":"Blastomere fixation techniques and risk of misdiagnosis for PGD of aneuploidy","volume":"4","author":"Velilla","year":"2002","journal-title":"Reprod Biomed Online"},{"key":"10.1016\/j.fertnstert.2005.10.014_bib24","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1002\/(SICI)1097-0223(199812)18:13<1459::AID-PD514>3.0.CO;2-V","article-title":"Preimplantation diagnosis of the aneuploidies most commonly found in spontaneous abortions and live births","volume":"18","author":"Munn\u00e9","year":"1998","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.fertnstert.2005.10.014_bib25","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1002\/pd.887","article-title":"PGD analysis for aneuploidy in a patient heterozygous for a polymorphism of chromosome 16 (16qh\u2212)","volume":"24","author":"Colls","year":"2004","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.fertnstert.2005.10.014_bib26","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1159\/000134497","article-title":"Simultaneous enumeration of chromosomes 13, 18, 21, X and Y in interphase cells for preimplantation genetic diagnosis","volume":"75","author":"Munn\u00e9","year":"1996","journal-title":"Cytogenet Cell Genet"},{"key":"10.1016\/j.fertnstert.2005.10.014_bib27","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S1472-6483(10)60501-9","article-title":"Differences in chromosome susceptibility to aneuploidy and survival to first trimester","volume":"8","author":"Munn\u00e9","year":"2004","journal-title":"Reprod Biomed Online"},{"key":"10.1016\/j.fertnstert.2005.10.014_bib28","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/S0015-0282(16)57739-5","article-title":"Embryo morphology, developmental rates and maternal age are correlated with chromosome abnormalities","volume":"64","author":"Munn\u00e9","year":"1995","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2005.10.014_bib29","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S1472-6483(10)61988-8","article-title":"Chromosome abnormalities in 1255 cleavage-stage human embryos","volume":"1","author":"M\u00e1rquez","year":"2000","journal-title":"Reprod Biomed Online"},{"key":"10.1016\/j.fertnstert.2005.10.014_bib30","unstructured":"McCullagh P, Nelder JA. Generalized linear models. London: Chapman & Hall."},{"key":"10.1016\/j.fertnstert.2005.10.014_bib31","first-page":"282","article-title":"Hook EB (1981). Rates of chromosome abnormalities at different maternal ages","volume":"58","year":"1997","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.fertnstert.2005.10.014_bib32","series-title":"Prenatal diagnosis and screening","first-page":"351","article-title":"Chromosome abnormalities","author":"Hook","year":"1992"},{"key":"10.1016\/j.fertnstert.2005.10.014_bib33","first-page":"465","article-title":"Does the karyotype of a spontaneous abortion predict the karyotype of a subsequent abortion? Evidence from 273 women with two karyotyped spontaneous abortions","volume":"41","author":"Warburton","year":"1987","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.fertnstert.2005.10.014_bib34","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S1472-6483(12)60113-8","article-title":"The role of preimplantation diagnosis for aneuploidy","volume":"4","author":"Gianaroli","year":"2001","journal-title":"Reprod Biomed Online"},{"key":"10.1016\/j.fertnstert.2005.10.014_bib35","doi-asserted-by":"crossref","first-page":"2849","DOI":"10.1093\/humrep\/deh536","article-title":"Comparison of blastocyst transfer with or without preimplantation genetic diagnosis for aneuploidy screening in couples with advanced maternal age","volume":"19","author":"Staessen","year":"2004","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2005.10.014_bib36","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0303-7207(00)00354-3","article-title":"The developmental potential of cryopreserved human embryos","volume":"169","author":"Edgar","year":"2000","journal-title":"Mol Cell Endocrinol"},{"key":"10.1016\/j.fertnstert.2005.10.014_bib37","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S1472-6483(10)61938-4","article-title":"Preimplantation genetic diagnosis of numerical and structural chromosome abnormalities","volume":"4","author":"Munn\u00e9","year":"2002","journal-title":"Reprod Biomed Online"},{"key":"10.1016\/j.fertnstert.2005.10.014_bib38","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.fertnstert.2005.02.027","article-title":"Preimplantation genetic diagnosis reduces pregnancy loss in women 35 and older with a history of recurrent miscarriages","volume":"84","author":"Munn\u00e9","year":"2005","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2005.10.014_bib39","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/S0015-0282(99)00143-0","article-title":"In vitro fertilization plus preimplantation genetic diagnosis in patients with recurrent miscarriage","volume":"71","author":"Pellicer","year":"1999","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2005.10.014_bib40","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.fertnstert.2004.06.071","article-title":"Preimplantation genetic diagnosis for aneuploidy screening in patients with unexplained recurrent miscarriages","volume":"83","author":"Platteau","year":"2005","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2005.10.014_bib41","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1093\/humrep\/deg015","article-title":"Chromosomal abnormalities and embryo development in recurrent miscarriage couples","volume":"18","author":"Rubio","year":"2003","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2005.10.014_bib42","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1023\/A:1022552713015","article-title":"FISH preimplantation diagnosis of chromosome aneuploidy in recurrent pregnancy wastage","volume":"15","author":"Vidal","year":"1998","journal-title":"J Assist Reprod Genet"},{"key":"10.1016\/j.fertnstert.2005.10.014_bib43","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1093\/humrep\/deg308","article-title":"Risk of spontaneous abortion in singleton and twin pregnancies after IVF\/ICSI","volume":"18","author":"Tummers","year":"2003","journal-title":"Hum Reprod"}],"container-title":["Fertility and Sterility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028205038550?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028205038550?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T07:11:18Z","timestamp":1758006678000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0015028205038550"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,2]]},"references-count":43,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2006,2]]}},"alternative-id":["S0015028205038550"],"URL":"https:\/\/doi.org\/10.1016\/j.fertnstert.2005.10.014","relation":{},"ISSN":["0015-0282"],"issn-type":[{"value":"0015-0282","type":"print"}],"subject":[],"published":{"date-parts":[[2006,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Preimplantation genetic diagnosis significantly reduces pregnancy loss in infertile couples: a multicenter study","name":"articletitle","label":"Article Title"},{"value":"Fertility and Sterility","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fertnstert.2005.10.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}