{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T21:19:25Z","timestamp":1778275165962,"version":"3.51.4"},"reference-count":16,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2006,7,1]],"date-time":"2006-07-01T00:00:00Z","timestamp":1151712000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,7,1]],"date-time":"2006-07-01T00:00:00Z","timestamp":1151712000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","fertstert.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fertility and Sterility"],"published-print":{"date-parts":[[2006,7]]},"DOI":"10.1016\/j.fertnstert.2005.12.022","type":"journal-article","created":{"date-parts":[[2006,6,1]],"date-time":"2006-06-01T15:41:59Z","timestamp":1149176519000},"page":"233-235","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"title":["Generation of 4-hydroxy-2-nonenal modified proteins in testes predicts improvement in spermatogenesis after varicocelectomy"],"prefix":"10.1016","volume":"86","author":[{"given":"Koji","family":"Shiraishi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsusuke","family":"Naito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.fertnstert.2005.12.022_bib1","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/S0015-0282(16)54288-5","article-title":"The pathophysiology of varicocele in male infertility","volume":"55","author":"Takihara","year":"1991","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2005.12.022_bib2","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1007\/s11934-001-0035-7","article-title":"The pathophsyiology of varicocele-associated male infertility","volume":"2","author":"Schoor","year":"2001","journal-title":"Curr Urol Rep"},{"key":"10.1016\/j.fertnstert.2005.12.022_bib3","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1093\/humupd\/7.5.461","article-title":"Varicocele and male infertility","volume":"7","author":"Marmar","year":"2001","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.fertnstert.2005.12.022_bib4","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1016\/S0022-5347(05)68818-0","article-title":"Varicocele is associated with elevated spermatozoal reactive oxygen species prosuction and diminished seminal plasma antioxidant capacity","volume":"161","author":"Hendin","year":"1999","journal-title":"J Urol"},{"key":"10.1016\/j.fertnstert.2005.12.022_bib5","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1046\/j.1464-410X.2000.00755.x","article-title":"The roles of reactive oxygen species in testicular dysfunction associated with varicocele","volume":"86","author":"K\u00f6ksal","year":"2000","journal-title":"BJU Int"},{"key":"10.1016\/j.fertnstert.2005.12.022_bib6","doi-asserted-by":"crossref","first-page":"2608","DOI":"10.1093\/humrep\/dei063","article-title":"Increased expression of Leydig cell heme oxygenase-1 preserves spermatogenesis in varicocele","volume":"20","author":"Shiraishi","year":"2005","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2005.12.022_bib7","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/S0163-7827(03)00014-6","article-title":"4-hydroxy-2-nonenal","volume":"42","author":"Uchida","year":"2003","journal-title":"Prog Lipid Res"},{"key":"10.1016\/j.fertnstert.2005.12.022_bib8","series-title":"WHO laboratory manual for the examination of human semen and sperm-cervical mucus interaction","year":"1999"},{"key":"10.1016\/j.fertnstert.2005.12.022_bib9","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1093\/humupd\/7.1.65","article-title":"Varicocele treatment in the light of evidence-based andrology","volume":"7","author":"Kamischke","year":"2001","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.fertnstert.2005.12.022_bib10","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1016\/S0140-6736(03)13503-9","article-title":"Assessment of efficacy of varicocele repair for male subfertility","volume":"361","author":"Evers","year":"2003","journal-title":"Lancet"},{"key":"10.1016\/j.fertnstert.2005.12.022_bib11","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/S0015-0282(99)00567-1","article-title":"Relationship between oxidative stress, semen characteristics, and clinical diagnosis in men undergoing infertility investigation","volume":"73","author":"Pasqualotto","year":"2000","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2005.12.022_bib12","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1093\/humrep\/17.3.718","article-title":"Polymorphism of glutathione S-transferase M1 and male infertility in Taiwanese patients with varicocele","volume":"17","author":"Chen","year":"2002","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2005.12.022_bib13","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1016\/j.fertnstert.2004.11.057","article-title":"GSTT1 and GSTM1 polymorphisms are associated with improvement in seminal findings after varicocelectomy","volume":"83","author":"Okubo","year":"2005","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2005.12.022_bib14","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/j.fertnstert.2004.07.976","article-title":"Deletions in L-type calcium channela1 subunit testicular transcripts correlate with testicular cadmium and apoptosis in infertile men with varicoceles","volume":"83","author":"Benoff","year":"2005","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2005.12.022_bib15","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1172\/JCI0213190","article-title":"Leydig cell-derived heme oxygenase-1 regulates apoptosis of premeiotic germ cells in response to stress","volume":"109","author":"Ozawa","year":"2002","journal-title":"J Clin Invest"},{"key":"10.1016\/j.fertnstert.2005.12.022_bib16","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1080\/00365590310008695","article-title":"Proliferating cell nuclear antigen in testes of infertile men with varicocele\u2014preliminary results of interrelationship with sperm count before and after varicocelectomy","volume":"37","author":"Salama","year":"2003","journal-title":"Scand J Urol Nephrol"}],"container-title":["Fertility and Sterility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001502820600536X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001502820600536X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T07:13:00Z","timestamp":1758006780000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S001502820600536X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,7]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006,7]]}},"alternative-id":["S001502820600536X"],"URL":"https:\/\/doi.org\/10.1016\/j.fertnstert.2005.12.022","relation":{},"ISSN":["0015-0282"],"issn-type":[{"value":"0015-0282","type":"print"}],"subject":[],"published":{"date-parts":[[2006,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Generation of 4-hydroxy-2-nonenal modified proteins in testes predicts improvement in spermatogenesis after varicocelectomy","name":"articletitle","label":"Article Title"},{"value":"Fertility and Sterility","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fertnstert.2005.12.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}