{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T23:07:09Z","timestamp":1782601629439,"version":"3.54.5"},"reference-count":39,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2006,8,1]],"date-time":"2006-08-01T00:00:00Z","timestamp":1154390400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,8,1]],"date-time":"2006-08-01T00:00:00Z","timestamp":1154390400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,5,27]],"date-time":"2022-05-27T00:00:00Z","timestamp":1653609600000},"content-version":"vor","delay-in-days":5778,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","fertstert.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fertility and Sterility"],"published-print":{"date-parts":[[2006,8]]},"DOI":"10.1016\/j.fertnstert.2005.12.059","type":"journal-article","created":{"date-parts":[[2006,6,15]],"date-time":"2006-06-15T08:46:02Z","timestamp":1150361162000},"page":"310-320","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":36,"title":["Preimplantation genetic diagnosis for Marfan syndrome"],"prefix":"10.1016","volume":"86","author":[{"given":"Claudia","family":"Spits","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martine","family":"De Rycke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Willem","family":"Verpoest","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Willy","family":"Lissens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andre","family":"Van Steirteghem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inge","family":"Liebaers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Sermon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fertnstert.2005.12.059_bib1","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1146\/annurev.med.51.1.481","article-title":"The Marfan syndrome","volume":"51","author":"Pyeritz","year":"2000","journal-title":"Annu Rev Med"},{"key":"10.1016\/j.fertnstert.2005.12.059_bib2","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1002\/humu.10113","article-title":"Mutations of FBN1 and genotype-phenotype correlations in Marfan syndrome and related fibrillinopathies","volume":"20","author":"Robinson","year":"2002","journal-title":"Hum Mutat"},{"key":"10.1016\/j.fertnstert.2005.12.059_bib3","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1016\/S0140-6736(04)16209-0","article-title":"Preimplantation genetic diagnosis","volume":"363","author":"Sermon","year":"2004","journal-title":"Lancet"},{"key":"10.1016\/j.fertnstert.2005.12.059_bib4","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1023\/A:1022540410290","article-title":"Preimplantation genetic diagnosis of human embryos for Marfan\u2019s syndrome","volume":"15","author":"Blaszczyk","year":"1998","journal-title":"J Assist Reprod Genet"},{"key":"10.1016\/j.fertnstert.2005.12.059_bib5","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.1093\/humrep\/13.6.1656","article-title":"Successful outcome with day 4 embryo transfer after preimplantation diagnosis for genetically transmitted diseases","volume":"13","author":"Grifo","year":"1998","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2005.12.059_bib6","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1093\/molehr\/2.9.713","article-title":"Preimplantation genetic testing for Marfan syndrome","volume":"2","author":"Harton","year":"1996","journal-title":"Mol Hum Reprod"},{"key":"10.1016\/j.fertnstert.2005.12.059_bib7","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1159\/000264355","article-title":"Preimplantation genetic diagnosis in Marfan syndrome","volume":"11","author":"Kilpatrick","year":"1996","journal-title":"Fetal Diagn Ther"},{"key":"10.1016\/j.fertnstert.2005.12.059_bib8","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0015-0282(98)00412-9","article-title":"Preimplantation genetic diagnosis of Marfan syndrome with the use of fluorescent polymerase chain reaction and the Automated Laser Fluorescence DNA Sequencer","volume":"71","author":"Sermon","year":"1999","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2005.12.059_bib9","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1002\/pd.223","article-title":"Strategies for prenatal and preimplantation genetic diagnosis in Marfan syndrome (MFS)","volume":"22","author":"Loeys","year":"2002","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.fertnstert.2005.12.059_bib10","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1038\/nm0895-798","article-title":"Marfan syndrome as a paradigm for transcript-targeted preimplantation diagnosis of heterozygous mutations","volume":"1","author":"Eldadah","year":"1995","journal-title":"Nat Med"},{"key":"10.1016\/j.fertnstert.2005.12.059_bib11","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1093\/molehr\/6.5.391","article-title":"Multiplex PCR of polymorphic markers flanking the CFTR gene; a general approach for preimplantation genetic diagnosis of cystic fibrosis","volume":"6","author":"Dreesen","year":"2000","journal-title":"Mol Hum Reprod"},{"key":"10.1016\/j.fertnstert.2005.12.059_bib12","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1093\/molehr\/gag065","article-title":"Improving clinical preimplantation genetic diagnosis for cystic fibrosis by duplex PCR using two polymorphic markers or one polymorphic marker in combination with the detection of the DeltaF508 mutation","volume":"9","author":"Goossens","year":"2003","journal-title":"Mol Hum Reprod"},{"key":"10.1016\/j.fertnstert.2005.12.059_bib13","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1093\/molehr\/gah170","article-title":"Preimplantation genetic diagnosis for neurofibromatosis type 1","volume":"11","author":"Spits","year":"2005","journal-title":"Mol Hum Reprod"},{"key":"10.1016\/j.fertnstert.2005.12.059_bib14","article-title":"Obstetric complications in Marfan syndrome","author":"Meijboom","year":"2005","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.fertnstert.2005.12.059_bib15","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1093\/eurheartj\/ehi103","article-title":"Pregnancy and aortic root growth in the Marfan syndrome","volume":"26","author":"Meijboom","year":"2005","journal-title":"Eur Heart J"},{"key":"10.1016\/j.fertnstert.2005.12.059_bib16","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1111\/j.1471-0528.1997.tb11045.x","article-title":"Outcome of pregnancy in women with Marfan\u2019s syndrome","volume":"104","author":"Lipscomb","year":"1997","journal-title":"Br J Obstet Gynaecol"},{"key":"10.1016\/j.fertnstert.2005.12.059_bib17","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1016\/0002-9378(95)90655-X","article-title":"A prospective longitudinal evaluation of pregnancy in the Marfan syndrome","volume":"173","author":"Rossiter","year":"1995","journal-title":"Am J Obstet Gynaecol"},{"key":"10.1016\/j.fertnstert.2005.12.059_bib18","first-page":"723","article-title":"Obstetric and gynecologic complications in women with Marfan syndrome","volume":"48","author":"Rahman","year":"2003","journal-title":"J Reprod Med"},{"key":"10.1016\/j.fertnstert.2005.12.059_bib19","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1159\/000153752","article-title":"Use of a simple method for the Epstein-Barr virus transformation of lymphocytes from members of large families of Reunion Island","volume":"38","author":"Ventura","year":"1988","journal-title":"Hum Hered"},{"key":"10.1016\/j.fertnstert.2005.12.059_bib20","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1093\/molehr\/gag054","article-title":"Preimplantation genetic diagnosis for Charcot-Marie-Tooth disease type 1A","volume":"9","author":"De Vos","year":"2003","journal-title":"Mol Hum Reprod"},{"key":"10.1016\/j.fertnstert.2005.12.059_bib21","doi-asserted-by":"crossref","first-page":"2807","DOI":"10.1093\/humrep\/17.11.2807","article-title":"Preimplantation genetic diagnosis for fragile Xa syndrome","volume":"17","author":"Platteau","year":"2002","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2005.12.059_bib22","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1093\/humrep\/13.suppl_1.186","article-title":"Clinical experience with preimplantation genetic diagnosis and intracytoplasmic sperm injection","volume":"13","author":"Liebaers","year":"1998","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2005.12.059_bib23","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1093\/humrep\/13.suppl_1.76","article-title":"Intracytoplasmic sperm injection","volume":"13","author":"Joris","year":"1998","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2005.12.059_bib24","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1093\/humupd\/dmh004","article-title":"A review of ten years experience of ICSI","volume":"10","author":"Devroey","year":"2004","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.fertnstert.2005.12.059_bib25","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1016\/j.fertnstert.2004.10.054","article-title":"Blastocyst formation in in vitro fertilization versus intracytoplasmic sperm injection cycles","volume":"83","author":"Van Landuyt","year":"2005","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2005.12.059_bib26","doi-asserted-by":"crossref","first-page":"1896","DOI":"10.1093\/humrep\/deg355","article-title":"Comparison of the results of human embryo biopsy and outcome of PGD after zona drilling using acid Tyrode medium or a laser","volume":"18","author":"Joris","year":"2003","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2005.12.059_bib27","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1006\/bmme.1997.2635","article-title":"Preimplantation diagnosis of single gene disorders by two-step oocyte genetic analysis using first and second polar body","volume":"62","author":"Verlinsky","year":"1997","journal-title":"Biochem Mol Med"},{"key":"10.1016\/j.fertnstert.2005.12.059_bib28","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1093\/humrep\/15.suppl_4.69","article-title":"Preimplantation genetic diagnosis","volume":"15","author":"Gianaroli","year":"2000","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2005.12.059_bib29","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1056\/NEJM199407213310302","article-title":"A molecular approach to the stratification of cardiovascular risk in families with Marfan\u2019s syndrome","volume":"331","author":"Pereira","year":"1994","journal-title":"N Engl J Med"},{"key":"10.1016\/j.fertnstert.2005.12.059_bib30","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1093\/humrep\/deh579","article-title":"Best practice guidelines for clinical preimplantation genetic diagnosis (PGD) and preimplantation genetic screening (PGS)","volume":"20","author":"Thornhill","year":"2005","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2005.12.059_bib31","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1093\/oxfordjournals.humrep.a138745","article-title":"Use of a polymorphic dinucleotide repeat sequence to detect nonblastomeric contamination of the polymerase chain reaction in biopsy samples for preimplantation diagnosis","volume":"9","author":"Pickering","year":"1994","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2005.12.059_bib32","first-page":"1005","article-title":"Simultaneous DNA \u201cfingerprinting,\u201d diagnosis of sex and single-gene defect status from single cells","volume":"10","author":"Findlay","year":"1995","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2005.12.059_bib33","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1093\/humrep\/deh153","article-title":"Novel universal approach for preimplantation genetic diagnosis of beta-thalassaemia in combination with HLA matching of embryos","volume":"19","author":"Van de Velde","year":"2004","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2005.12.059_bib34","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1093\/oxfordjournals.humrep.a137635","article-title":"Using PCR in preimplantation genetic disease diagnosis","volume":"7","author":"Navidi","year":"1992","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2005.12.059_bib35","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1093\/humrep\/16.1.43","article-title":"Controlling misdiagnosis errors in preimplantation genetic diagnosis","volume":"16","author":"Lewis","year":"2001","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2005.12.059_bib36","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1002\/1097-0223(200012)20:13<1030::AID-PD977>3.0.CO;2-D","article-title":"Embryo implantation after biopsy of one or two cells from cleavage-stage embryos with a view to preimplantation genetic diagnosis","volume":"20","author":"Van de Velde","year":"2000","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.fertnstert.2005.12.059_bib37","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1093\/oxfordjournals.humrep.a137173","article-title":"Human preimplantation development in vitro is not adversely affected by biopsy at the 8-cell stage","volume":"5","author":"Hardy","year":"1990","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2005.12.059_bib38","unstructured":"Goossens V, De Rycke M, Staessen C, De Vos A, Michiels A, Verpoest W, et al. Embryo development and diagnostic efficiency and accuracy after biopsy of one or two blastomeres for preimplantation genetic diagnosis (PGD). In preparation."},{"key":"10.1016\/j.fertnstert.2005.12.059_bib39","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1093\/humrep\/deh552","article-title":"ESHRE PGD Consortium data collection IV","volume":"20","author":"Sermon","year":"2005","journal-title":"Hum Reprod"}],"container-title":["Fertility and Sterility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028206006522?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028206006522?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T07:13:42Z","timestamp":1758006822000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0015028206006522"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,8]]},"references-count":39,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2006,8]]}},"alternative-id":["S0015028206006522"],"URL":"https:\/\/doi.org\/10.1016\/j.fertnstert.2005.12.059","relation":{},"ISSN":["0015-0282"],"issn-type":[{"value":"0015-0282","type":"print"}],"subject":[],"published":{"date-parts":[[2006,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Preimplantation genetic diagnosis for Marfan syndrome","name":"articletitle","label":"Article Title"},{"value":"Fertility and Sterility","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fertnstert.2005.12.059","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}