{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:19:32Z","timestamp":1760188772126,"version":"3.44.0"},"reference-count":38,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2006,10,1]],"date-time":"2006-10-01T00:00:00Z","timestamp":1159660800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,10,1]],"date-time":"2006-10-01T00:00:00Z","timestamp":1159660800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,5,27]],"date-time":"2022-05-27T00:00:00Z","timestamp":1653609600000},"content-version":"vor","delay-in-days":5717,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","fertstert.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fertility and Sterility"],"published-print":{"date-parts":[[2006,10]]},"DOI":"10.1016\/j.fertnstert.2006.02.106","type":"journal-article","created":{"date-parts":[[2006,9,8]],"date-time":"2006-09-08T15:25:10Z","timestamp":1157729110000},"page":"961-971","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Aberrant expression of apoptosis proteins and ultrastructural aberrations in uterine leiomyomas from patients with hereditary leiomyomatosis and renal cell carcinoma"],"prefix":"10.1016","volume":"86","author":[{"given":"Noel C.","family":"Wortham","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N. Afrina","family":"Alam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ella","family":"Barclay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick J.","family":"Pollard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bart E.","family":"Wagner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanjiv","family":"Manek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George","family":"Elia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian P.M.","family":"Tomlinson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.fertnstert.2006.02.106_bib1","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1038\/ng849","article-title":"Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer","volume":"30","author":"Tomlinson","year":"2002","journal-title":"Nat Genet"},{"key":"10.1016\/j.fertnstert.2006.02.106_bib2","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1093\/hmg\/ddg148","article-title":"Genetic and functional analyses of FH mutations in multiple cutaneous and uterine leiomyomatosis, hereditary leiomyomatosis and renal cancer, and fumarate hydratase deficiency","volume":"12","author":"Alam","year":"2003","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.fertnstert.2006.02.106_bib3","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1080\/07853890310018458","article-title":"The TCA cycle and tumorigenesis: the examples of fumarate hydratase and succinate dehydrogenase","volume":"35","author":"Pollard","year":"2003","journal-title":"Ann Med"},{"key":"10.1016\/j.fertnstert.2006.02.106_bib4","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1002\/path.1686","article-title":"Evidence of increased microvessel density and activation of the hypoxia pathway in tumours from the hereditary leiomyomatosis and renal cell cancer syndrome","volume":"205","author":"Pollard","year":"2005","journal-title":"J Pathol"},{"key":"10.1016\/j.fertnstert.2006.02.106_bib5","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.ccr.2004.11.022","article-title":"Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase","volume":"7","author":"Selak","year":"2005","journal-title":"Cancer Cell"},{"key":"10.1016\/j.fertnstert.2006.02.106_bib6","doi-asserted-by":"crossref","first-page":"2231","DOI":"10.1093\/hmg\/ddi227","article-title":"Accumulation of Krebs cycle intermediates and over-expression of HIF1{alpha} in tumours which result from germline FH and SDH mutations","volume":"14","author":"Pollard","year":"2005","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.fertnstert.2006.02.106_bib7","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.ccr.2005.06.017","article-title":"HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: novel role of fumarate in regulation of HIF stability","volume":"8","author":"Isaacs","year":"2005","journal-title":"Cancer Cell"},{"key":"10.1016\/j.fertnstert.2006.02.106_bib8","doi-asserted-by":"crossref","first-page":"4305","DOI":"10.1074\/jbc.M312241200","article-title":"c-Myc sensitization to oxygen deprivation-induced cell death is dependent on Bax\/Bak, but is independent of p53 and hypoxia-inducible factor-1","volume":"279","author":"Brunelle","year":"2004","journal-title":"J Biol Chem"},{"issue":"Suppl 2","key":"10.1016\/j.fertnstert.2006.02.106_bib9","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1159\/000055275","article-title":"Molecular bases for the actions of ovarian sex steroids in the regulation of proliferation and apoptosis of human uterine leiomyoma","volume":"57","author":"Matsuo","year":"1999","journal-title":"Oncology"},{"key":"10.1016\/j.fertnstert.2006.02.106_bib10","first-page":"293","article-title":"Increased expression of Bcl-2 protein in human uterine leiomyoma and its up-regulation by progesterone","volume":"82","author":"Matsuo","year":"1997","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2006.02.106_bib11","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.jsbmb.2003.09.007","article-title":"Differential expression of Akt\/protein kinase B, Bcl-2 and Bax proteins in human leiomyoma and myometrium","volume":"87","author":"Kovacs","year":"2003","journal-title":"J Steroid Biochem Mol Biol"},{"key":"10.1016\/j.fertnstert.2006.02.106_bib12","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.jsgi.2003.10.003","article-title":"Bcl-2 receptor expression in patients with uterine smooth muscle tumors: an immunohistochemical analysis comparing leiomyoma, uterine smooth muscle tumor of uncertain malignant potential, and leiomyosarcoma","volume":"11","author":"Bodner","year":"2004","journal-title":"J Soc Gynecol Investig"},{"key":"10.1016\/j.fertnstert.2006.02.106_bib13","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0960-0760(01)00177-7","article-title":"Expression of Bcl-2, Bcl-x, Mcl-1, Bax and Bak in human uterine leiomyomas and myometrium during the menstrual cycle and after menopause","volume":"80","author":"Wu","year":"2002","journal-title":"J Steroid Biochem Mol Biol"},{"key":"10.1016\/j.fertnstert.2006.02.106_bib14","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1038\/nrc883","article-title":"The Bcl2 family: regulators of the cellular life-or-death switch","volume":"2","author":"Cory","year":"2002","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.fertnstert.2006.02.106_bib15","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.bbamcr.2003.08.009","article-title":"The role of Bcl-2 family members in tumorigenesis","volume":"1644","author":"Kirkin","year":"2004","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.fertnstert.2006.02.106_bib16","doi-asserted-by":"crossref","first-page":"5367","DOI":"10.1074\/jbc.M203392200","article-title":"Association of Bax and Bak homo-oligomers in mitochondria","volume":"278","author":"Mikhailov","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.fertnstert.2006.02.106_bib17","doi-asserted-by":"crossref","first-page":"7668","DOI":"10.1038\/sj.onc.1204995","article-title":"Cellular damage signals promote sequential changes at the N-terminus and BH-1 domain of the pro-apoptotic protein Bak","volume":"20","author":"Griffiths","year":"2001","journal-title":"Oncogene"},{"key":"10.1016\/j.fertnstert.2006.02.106_bib18","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1006\/excr.1999.4557","article-title":"Effects of differential overexpression of Bcl-2 on apoptosis, proliferation, and telomerase activity in Jurkat T cells","volume":"251","author":"Johnson","year":"1999","journal-title":"Exp Cell Res"},{"key":"10.1016\/j.fertnstert.2006.02.106_bib19","doi-asserted-by":"crossref","first-page":"14127","DOI":"10.1074\/jbc.M109939200","article-title":"Bax and Bak independently promote cytochrome C release from mitochondria","volume":"277","author":"Degenhardt","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1016\/j.fertnstert.2006.02.106_bib20","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/j.steroids.2003.08.017","article-title":"Effects of progesterone on growth factor expression in human uterine leiomyoma","volume":"68","author":"Maruo","year":"2003","journal-title":"Steroids"},{"key":"10.1016\/j.fertnstert.2006.02.106_bib21","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1080\/01913120490452630","article-title":"Case for the panel of ultrastructural pathology\u2014uterine leiomyoma","volume":"28","author":"Eyden","year":"2004","journal-title":"Ultrastruct Pathol"},{"key":"10.1016\/j.fertnstert.2006.02.106_bib22","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/BF01605984","article-title":"Cytoskeletal filaments in the smooth muscle cells of uterine leiomyomata and myometrium: an ultrastructural and immunohistochemical analysis","volume":"420","author":"Eyden","year":"1992","journal-title":"Virchows Arch A Pathol Anat Histopathol"},{"key":"10.1016\/j.fertnstert.2006.02.106_bib23","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1093\/humupd\/4.5.520","article-title":"The ultrastructure of fibromyomatous myometrium and its relationship to infertility","volume":"4","author":"Richards","year":"1998","journal-title":"Hum Reprod Update"},{"year":"1994","series-title":"Diagnostic transmission electron microscopy of tumors, with clinicopathological, immunohistochemical, and cytogenetic correlations","author":"Erlandson","key":"10.1016\/j.fertnstert.2006.02.106_bib24"},{"key":"10.1016\/j.fertnstert.2006.02.106_bib25","unstructured":"Ylstra B. Available from: http:\/\/www.vumc.nl\/microarrays\/onderzoek\/index.html?protocols.html\u223choofd. Accessed: March 2005."},{"key":"10.1016\/j.fertnstert.2006.02.106_bib26","doi-asserted-by":"crossref","first-page":"8512","DOI":"10.1158\/1078-0432.CCR-04-0734","article-title":"Mitochondrial DNA quantity increases with histopathologic grade in premalignant and malignant head and neck lesions","volume":"10","author":"Kim","year":"2004","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.fertnstert.2006.02.106_bib27","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/S0025-6196(12)65098-8","article-title":"Uterine leiomyosarcomas and benign smooth muscle tumors: usefulness of nuclear DNA patterns studied by flow cytometry","volume":"63","author":"Tsushima","year":"1988","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/j.fertnstert.2006.02.106_bib28","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0092-8674(00)81683-9","article-title":"The hallmarks of cancer","volume":"100","author":"Hanahan","year":"2000","journal-title":"Cell"},{"key":"10.1016\/j.fertnstert.2006.02.106_bib29","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1038\/nrc704","article-title":"Hypoxia\u2014a key regulatory factor in tumour growth","volume":"2","author":"Harris","year":"2002","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.fertnstert.2006.02.106_bib30","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1038\/28867","article-title":"Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis","volume":"394","author":"Carmeliet","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.fertnstert.2006.02.106_bib31","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1111\/j.1349-7006.2005.00065.x","article-title":"Mechanism of HIF-1alpha-dependent suppression of hypoxia-induced apoptosis in squamous cell carcinoma cells","volume":"96","author":"Sasabe","year":"2005","journal-title":"Cancer Sci"},{"key":"10.1016\/j.fertnstert.2006.02.106_bib32","doi-asserted-by":"crossref","first-page":"9215","DOI":"10.1074\/jbc.M312225200","article-title":"Hypoxia selection of death-resistant cells","volume":"279","author":"Dong","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1016\/j.fertnstert.2006.02.106_bib33","doi-asserted-by":"crossref","first-page":"2420","DOI":"10.1002\/1097-0142(19811201)48:11<2420::AID-CNCR2820481114>3.0.CO;2-9","article-title":"A comparative study of smooth muscle tumors utilizing light and electron microscopy, immunocytochemical staining and enzymatic assay","volume":"48","author":"Bures","year":"1981","journal-title":"Cancer"},{"key":"10.1016\/j.fertnstert.2006.02.106_bib34","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0015-0282(00)01660-5","article-title":"Ultrastructural comparison of uterine leiomyoma cells from the same myoma nodule before and after gonadotropin-releasing hormone agonist treatment","volume":"75","author":"Ito","year":"2001","journal-title":"Fertil Steril"},{"issue":"Suppl 3","key":"10.1016\/j.fertnstert.2006.02.106_bib35","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1016\/j.fertnstert.2004.04.030","article-title":"Comparative ultrastructure of collagen fibrils in uterine leiomyomas and normal myometrium","volume":"82","author":"Leppert","year":"2004","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2006.02.106_bib36","doi-asserted-by":"crossref","first-page":"2098","DOI":"10.1016\/j.biocel.2005.02.029","article-title":"Lysosomal proteolysis in skeletal muscle","volume":"37","author":"Bechet","year":"2005","journal-title":"Int J Biochem Cell Biol"},{"key":"10.1016\/j.fertnstert.2006.02.106_bib37","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1038\/nrc1738","article-title":"Lysosomes and autophagy in cell death control","volume":"5","author":"Kroemer","year":"2005","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.fertnstert.2006.02.106_bib38","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1002\/path.1461","article-title":"SDHD mutations in head and neck paragangliomas result in destabilization of complex II in the mitochondrial respiratory chain with loss of enzymatic activity and abnormal mitochondrial morphology","volume":"201","author":"Douwes Dekker","year":"2003","journal-title":"J Pathol"}],"container-title":["Fertility and Sterility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001502820601154X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001502820601154X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T07:16:19Z","timestamp":1758006979000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S001502820601154X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,10]]},"references-count":38,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2006,10]]}},"alternative-id":["S001502820601154X"],"URL":"https:\/\/doi.org\/10.1016\/j.fertnstert.2006.02.106","relation":{},"ISSN":["0015-0282"],"issn-type":[{"type":"print","value":"0015-0282"}],"subject":[],"published":{"date-parts":[[2006,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Aberrant expression of apoptosis proteins and ultrastructural aberrations in uterine leiomyomas from patients with hereditary leiomyomatosis and renal cell carcinoma","name":"articletitle","label":"Article Title"},{"value":"Fertility and Sterility","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fertnstert.2006.02.106","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}