{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T16:37:43Z","timestamp":1789749463870,"version":"4.0.1"},"reference-count":33,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2007,5,1]],"date-time":"2007-05-01T00:00:00Z","timestamp":1177977600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,5,1]],"date-time":"2007-05-01T00:00:00Z","timestamp":1177977600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,5,27]],"date-time":"2022-05-27T00:00:00Z","timestamp":1653609600000},"content-version":"vor","delay-in-days":5505,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","fertstert.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fertility and Sterility"],"published-print":{"date-parts":[[2007,5]]},"DOI":"10.1016\/j.fertnstert.2006.08.111","type":"journal-article","created":{"date-parts":[[2007,1,16]],"date-time":"2007-01-16T19:38:30Z","timestamp":1168976310000},"page":"1166-1172","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":49,"title":["Novel method to characterize primary cultures of leiomyoma and myometrium with the use of confirmatory biomarker gene arrays"],"prefix":"10.1016","volume":"87","author":[{"given":"Minnie","family":"Malik","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William H.","family":"Catherino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fertnstert.2006.08.111_bib1","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1093\/aje\/kwh017","article-title":"Invited commentary: uterine leiomyomata\u2014we know so little but could learn so much","volume":"159","author":"Baird","year":"2004","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.fertnstert.2006.08.111_bib2","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1093\/ajcp\/94.4.435","article-title":"The frequency of uterine leiomyomas","volume":"94","author":"Cramer","year":"1990","journal-title":"Am J Clin Pathol"},{"key":"10.1016\/j.fertnstert.2006.08.111_bib3","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/S0015-0282(16)45789-4","article-title":"Uterine leiomyomata: etiology, symptomatology, and management","volume":"36","author":"Buttram","year":"1981","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2006.08.111_bib4","doi-asserted-by":"crossref","first-page":"852","DOI":"10.2105\/AJPH.78.7.852","article-title":"Hysterectomy in the United States, 1965\u20131984","volume":"78","author":"Pokras","year":"1988","journal-title":"Am J Public Health"},{"key":"10.1016\/j.fertnstert.2006.08.111_bib5","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/S0015-0282(03)00953-1","article-title":"Strategy for elucidating differentially expressed genes in leiomyomata identified by microarray technology","volume":"80","author":"Catherino","year":"2003","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2006.08.111_bib6","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1002\/gcc.20035","article-title":"Reduced dermatopontin expression is a molecular link between uterine leiomyomas and keloids","volume":"40","author":"Catherino","year":"2004","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1016\/j.fertnstert.2006.08.111_bib7","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1002\/cncr.20521","article-title":"Tissue microarray immunohistochemical expression of estrogen, progesterone, and androgen receptors in uterine leiomyomata and leiomyosarcoma","volume":"101","author":"Leitao","year":"2004","journal-title":"Cancer"},{"key":"10.1016\/j.fertnstert.2006.08.111_bib8","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1210\/en.2004-1377","article-title":"Gene expression profiling of leiomyoma and myometrial smooth muscle cells in response to transforming growth factor-beta","volume":"146","author":"Luo","year":"2005","journal-title":"Endocrinology"},{"key":"10.1016\/j.fertnstert.2006.08.111_bib9","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1136\/ijgc-00009577-200501000-00022","article-title":"Profiling of differentially expressed genes in human uterine leiomyomas","volume":"15","author":"Lee","year":"2005","journal-title":"Int J Gynecol Cancer"},{"key":"10.1016\/j.fertnstert.2006.08.111_bib10","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1002\/gcc.10281","article-title":"Uterine leiomyoma in the Eker rat: a unique model of important diseases of women","volume":"38","author":"Walker","year":"2003","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1016\/j.fertnstert.2006.08.111_bib11","first-page":"272","article-title":"Experimentally induced myofibroblastic neoplasia in guinea pigs","volume":"76","author":"Dallenbach","year":"1982","journal-title":"Indian J Med Res"},{"key":"10.1016\/j.fertnstert.2006.08.111_bib12","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1095\/biolreprod52.4.824","article-title":"Estrogen-induced guinea pig model for uterine leiomyomas: do the ovaries protect?","volume":"52","author":"Porter","year":"1995","journal-title":"Biol Reprod"},{"key":"10.1016\/j.fertnstert.2006.08.111_bib13","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1172\/JCI118850","article-title":"Estradiol-dependent uterine leiomyomas in transgenic mice","volume":"98","author":"Romangnolo","year":"1996","journal-title":"J Clin Invest"},{"key":"10.1016\/j.fertnstert.2006.08.111_bib14","doi-asserted-by":"crossref","first-page":"1963","DOI":"10.1038\/sj.onc.1201707","article-title":"The induction of uterine leiomyomas and mammary tumors in transgenic mice expressing polyomavirus (PyV) large T (LT) antigen is associated with the ability of PyV LT antigen to form specific complexes with retinoblastoma and CUTLI family members","volume":"16","author":"Webster","year":"1998","journal-title":"Oncogene"},{"key":"10.1016\/j.fertnstert.2006.08.111_bib15","first-page":"1308","article-title":"Production of prolactin by smooth muscle cells cultured from human uterine fibroid tumors","volume":"76","author":"Nowak","year":"1992","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2006.08.111_bib16","first-page":"736","article-title":"Expression of the CYP19 gene and its product aromatase cytochrome P450 in human uterine leiomyoma tissues and cells in culture","volume":"78","author":"Bulun","year":"1993","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2006.08.111_bib17","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1093\/molehr\/3.2.91","article-title":"Effects of a GnRH analogue on human smooth muscle cells cultured from normal myometrial and from uterine leiomyomal tissues","volume":"3","author":"Kobayashi","year":"1997","journal-title":"Mol Hum Reprod"},{"key":"10.1016\/j.fertnstert.2006.08.111_bib18","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1093\/molehr\/6.6.523","article-title":"HCG promotes proliferation of uterine leiomyomal cells more strongly than that of myometrial smooth muscle cells in vitro","volume":"6","author":"Horiuchi","year":"2000","journal-title":"Mol Hum Reprod"},{"key":"10.1016\/j.fertnstert.2006.08.111_bib19","doi-asserted-by":"crossref","first-page":"3852","DOI":"10.1210\/endo.141.10.7719","article-title":"In situ estrogen synthesized by aromatase P450 in uterine leiomyoma cells promotes cell growth probably via an autocrine\/intracrine mechanism","volume":"141","author":"Sumitani","year":"2000","journal-title":"Endocrinology"},{"key":"10.1016\/j.fertnstert.2006.08.111_bib20","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1016\/S0015-0282(98)00072-7","article-title":"Expression and hormonal regulation of monocyte chemotactic protein-1 in myometrium and leiomyomata","volume":"69","author":"Sozen","year":"1998","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2006.08.111_bib21","first-page":"913","article-title":"Human leiomyoma smooth muscle cells show increased expression of transforming growth factor-beta 3 (TGFbeta3) and altered responses to the antiproliferative effects of TGF beta","volume":"86","author":"Lee","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2006.08.111_bib22","first-page":"4138","article-title":"Regulation of transforming growth factor-\u03b21 expression by granulocyte macrophage-colony-stimulating factor in leiomyoma and myometrial smooth muscle cells","volume":"84","author":"Chegini","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2006.08.111_bib23","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1016\/S0015-0282(00)00418-0","article-title":"Transforming growth factor-\u03b23 is expressed at high levels in leiomyoma where it stimulates fibronectin expression and cell proliferation","volume":"73","author":"Arici","year":"2000","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2006.08.111_bib24","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1067\/mob.2003.118","article-title":"Expression, menstrual cycle-dependent activation, and bimodal mitogenic effect of transforming growth factor-\u03b21 in human myometrium and leiomyoma","volume":"188","author":"Arici","year":"2003","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.fertnstert.2006.08.111_bib25","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1210\/en.2004-1377","article-title":"Gene expression profiling of leiomyoma and myometrial smooth muscle cells in response to transforming growth factor-\u03b2","volume":"146","author":"Luo","year":"2004","journal-title":"Endocrinology"},{"key":"10.1016\/j.fertnstert.2006.08.111_bib26","first-page":"83","article-title":"Gene expression studies in leiomyomata: new directions for research","volume":"22","author":"Catherino","year":"2003","journal-title":"Semin Reprod Med"},{"key":"10.1016\/j.fertnstert.2006.08.111_bib27","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/S0015-0282(03)00958-0","article-title":"Microarray analysis in leiomyomas: which gene list is the correct list?","volume":"80","author":"Catherino","year":"2003","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2006.08.111_bib28","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1042\/bj3370537","article-title":"Dermatopontin interacts with transforming growth factor beta and enhances its biological activity","volume":"337","author":"Okamoto","year":"1999","journal-title":"Biochem J"},{"key":"10.1016\/j.fertnstert.2006.08.111_bib29","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/S0015-0282(02)03191-6","article-title":"Insights from gene arrays on the development and growth regulation of uterine leiomyomas","volume":"78","author":"Tsibris","year":"2002","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2006.08.111_bib30","series-title":"Molecular alterations in retinoic pathway of uterine leiomyomas","author":"Malik","year":"2005"},{"key":"10.1016\/j.fertnstert.2006.08.111_bib31","doi-asserted-by":"crossref","first-page":"e45","DOI":"10.1093\/nar\/29.9.e45","article-title":"A new mathematical model for relative quantification in real-time RT-PCR","volume":"29","author":"Pfaffl","year":"2001","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.fertnstert.2006.08.111_bib32","first-page":"5737","article-title":"Human uterine leiomyomata express higher levels of peroxisome proliferator-activated receptor gamma, retinoid X receptor alpha, and all-trans retinoic acid than myometrium","volume":"59","author":"Tsibris","year":"1999","journal-title":"Cancer Res"},{"key":"10.1016\/j.fertnstert.2006.08.111_bib33","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1093\/molehr\/gah199","article-title":"Growth dynamics of human leiomyoma cells and inhibitory effects of the peroxisome proliferator-activated receptor-gamma ligand, pioglitazone","volume":"11","author":"Loy","year":"2005","journal-title":"Mol Hum Reprod"}],"container-title":["Fertility and Sterility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028206044207?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028206044207?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T07:20:00Z","timestamp":1758007200000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0015028206044207"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,5]]},"references-count":33,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2007,5]]}},"alternative-id":["S0015028206044207"],"URL":"https:\/\/doi.org\/10.1016\/j.fertnstert.2006.08.111","relation":{},"ISSN":["0015-0282"],"issn-type":[{"value":"0015-0282","type":"print"}],"subject":[],"published":{"date-parts":[[2007,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Novel method to characterize primary cultures of leiomyoma and myometrium with the use of confirmatory biomarker gene arrays","name":"articletitle","label":"Article Title"},{"value":"Fertility and Sterility","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fertnstert.2006.08.111","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2007 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}