{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T04:37:21Z","timestamp":1792211841991,"version":"4.4.0"},"reference-count":30,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2008,5,1]],"date-time":"2008-05-01T00:00:00Z","timestamp":1209600000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,5,1]],"date-time":"2008-05-01T00:00:00Z","timestamp":1209600000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,5,27]],"date-time":"2022-05-27T00:00:00Z","timestamp":1653609600000},"content-version":"vor","delay-in-days":5139,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","fertstert.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fertility and Sterility"],"published-print":{"date-parts":[[2008,5]]},"DOI":"10.1016\/j.fertnstert.2007.03.086","type":"journal-article","created":{"date-parts":[[2007,8,8]],"date-time":"2007-08-08T07:20:09Z","timestamp":1186557609000},"page":"1406-1413","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"S","title":["Human granulosa-lutein cell in vitro production of progesterone, inhibin A, inhibin B, and activin A are dependent on follicular size and not the presence of the oocyte"],"prefix":"10.1016","volume":"89","author":[{"given":"Xuesong","family":"Wen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda J.","family":"Tozer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne M.","family":"Docherty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Talha","family":"Al-Shawaf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ray K.","family":"Iles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fertnstert.2007.03.086_bib1","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1002\/(SICI)1098-2795(199608)44:4<540::AID-MRD14>3.0.CO;2-1","article-title":"Mammalian oocyte growth in vitro is stimulated by soluble factor(s) produced by preantral granulosa cells and by Sertoli cells","volume":"44","author":"Cecconi","year":"1996","journal-title":"Mol Reprod Dev"},{"key":"10.1016\/j.fertnstert.2007.03.086_bib2","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1095\/biolreprod43.4.543","article-title":"Interactions between somatic cells and germ cells throughout mammalian oogenesis","volume":"43","author":"Buccione","year":"1990","journal-title":"Biol Reprod"},{"key":"10.1016\/j.fertnstert.2007.03.086_bib3","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1095\/biolreprod46.6.1196","article-title":"Mouse oocytes promote proliferation of granulosa cells from preantral and antral follicles in vitro","volume":"46","author":"Vanderhyden","year":"1992","journal-title":"Biol Reprod"},{"key":"10.1016\/j.fertnstert.2007.03.086_bib4","first-page":"131","article-title":"Oocyte-specific expression of growth\/differentiation factor-9","volume":"9","author":"McGrath","year":"1995","journal-title":"Mol Endocrinol"},{"key":"10.1016\/j.fertnstert.2007.03.086_bib5","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1038\/383531a0","article-title":"Growth differentiation factor-9 is required during early ovarian folliculogenesis","volume":"383","author":"Dong","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.fertnstert.2007.03.086_bib6","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1006\/dbio.1998.8865","article-title":"Growth promoting activity of oocytes on granulosa cells is decreased upon meiotic maturation","volume":"197","author":"Lanuza","year":"1998","journal-title":"Dev Biol"},{"key":"10.1016\/j.fertnstert.2007.03.086_bib7","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1095\/biolreprod63.3.839","article-title":"Oocyte-secreted factor(s) determine functional differences between bovine mural granulosa cells and cumulus cells","volume":"63","author":"Li","year":"2000","journal-title":"Biol Reprod"},{"key":"10.1016\/j.fertnstert.2007.03.086_bib8","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1210\/jcem-49-5-687","article-title":"The production of progesterone, androgens and estrogens by granulosa cells, thecal tissue, and stromal tissue from human ovaries in vitro","volume":"49","author":"McNatty","year":"1979","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2007.03.086_bib9","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1210\/jcem-48-4-686","article-title":"Healthy and atretic human follicles in the preovulatory phase: differences in evolution of follicular morphology and steroid content of follicular fluid","volume":"48","author":"Bomsel-Helmreich","year":"1979","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2007.03.086_bib10","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/S0015-0282(16)49340-4","article-title":"Ultrastructural characterization of human granulosa cells in stimulated cycles: correlation with oocyte fertilizability","volume":"45","author":"Rotmensch","year":"1986","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2007.03.086_bib11","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/S0015-0282(16)58163-1","article-title":"Subpopulations of human granulosa-luteal cells in natural and stimulated in vitro fertilization-embryo transfer cycles","volume":"65","author":"Gersak","year":"1996","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2007.03.086_bib12","doi-asserted-by":"crossref","first-page":"1814","DOI":"10.1093\/humrep\/16.9.1814","article-title":"Relationship of ovarian stimulation response with vascular endothelial growth factor and degree of granulosa cell apoptosis","volume":"16","author":"Quintana","year":"2001","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2007.03.086_bib13","first-page":"1670","article-title":"Regulation of inhibin alpha- and beta A-subunit messenger ribonucleic acid levels by chorionic gonadotrophin and recombinant follicle-stimulating hormone in cultured human granulosa-luteal cells","volume":"79","author":"Eramaa","year":"1994","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2007.03.086_bib14","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1016\/S0015-0282(16)58268-5","article-title":"Transforming growth factor \u2013 beta 1 and \u2013 beta 2 induce inhibin and activin beta B-subunit messenger ribonucleic acid levels in cultured human granulosa-luteal cells","volume":"65","author":"Eramaa","year":"1996","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2007.03.086_bib15","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1210\/endo.136.3.7867576","article-title":"Ovarian inhibin subunit gene expression: regulation by gonadotrophins and estradiol","volume":"136","author":"Aloi","year":"1995","journal-title":"Endocrinology"},{"key":"10.1016\/j.fertnstert.2007.03.086_bib16","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1023\/A:1022524516824","article-title":"Gonadotrophin control of secretion of dimeric inhibins and activin A by human granulosa-luteal cells in-vitro","volume":"14","author":"Muttukrishna","year":"1997","journal-title":"J Assist Reprod Genet"},{"key":"10.1016\/j.fertnstert.2007.03.086_bib17","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1677\/joe.0.1670289","article-title":"Regulation of immunoreactive inhibin A and B secretion in cultured human granulosa-luteal cells by gonadotrophins, activin A and insulin-like growth factor type-1 receptor","volume":"167","author":"Vanttinen","year":"2000","journal-title":"J Endocrinol"},{"key":"10.1016\/j.fertnstert.2007.03.086_bib18","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1093\/molehr\/7.4.319","article-title":"Gonadotrophins inhibit and activin induces expression of inhibin\/activin beta(B) subunit mRNA in cultured granulosa-luteal cells","volume":"7","author":"Liu","year":"2001","journal-title":"Mol Hum Reprod"},{"key":"10.1016\/j.fertnstert.2007.03.086_bib19","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1016\/j.fertnstert.2005.11.058","article-title":"Follicular fluid levels of inhibin A, inhibin B and activin A levels reflect changes in follicle size but are not independent markers of oocyte ability to fertilize","volume":"85","author":"Wen","year":"2006","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2007.03.086_bib20","doi-asserted-by":"crossref","first-page":"2561","DOI":"10.1093\/humrep\/deh487","article-title":"Characteristics of populations of granulosa cells from individual follicles in women undergoing \u201ccoasting\u201d during controlled ovarian stimulation (COS) for IVF","volume":"19","author":"Tozer","year":"2004","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2007.03.086_bib21","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1093\/oxfordjournals.humrep.a138765","article-title":"Serum concentrations of dimeric inhibin during the spontaneous human menstrual cycle and after treatment with exogenous gonadotrophin","volume":"9","author":"Muttukrishna","year":"1994","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2007.03.086_bib22","first-page":"1401","article-title":"Measurement of dimeric inhibin B throughout the human menstrual cycle","volume":"81","author":"Groome","year":"1996","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2007.03.086_bib23","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1111\/j.1365-2265.1994.tb02504.x","article-title":"Detection of dimeric inhibin throughout the human menstrual cycle by two-site enzyme immunoassay","volume":"40","author":"Groome","year":"1994","journal-title":"Clin Endocrinol"},{"key":"10.1016\/j.fertnstert.2007.03.086_bib24","doi-asserted-by":"crossref","first-page":"2549","DOI":"10.1210\/endo.140.6.6788","article-title":"Dimeric inhibin A and B production are differentially regulated by hormones and local factors in rat granulosa cells","volume":"140","author":"Lanuza","year":"1999","journal-title":"Endocrinology"},{"key":"10.1016\/j.fertnstert.2007.03.086_bib25","doi-asserted-by":"crossref","first-page":"2544","DOI":"10.1210\/endo.138.6.5190","article-title":"Regulation of follistatin production by rat granulosa cells in vitro","volume":"138","author":"Shintani","year":"1997","journal-title":"Endocrinology"},{"key":"10.1016\/j.fertnstert.2007.03.086_bib26","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1093\/humrep\/12.8.1714","article-title":"Inhibin A, inhibin B and activin A in the follicular fluid of regularly cycling women","volume":"12","author":"Magoffin","year":"1997","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2007.03.086_bib27","first-page":"3319","article-title":"Dynamic changes in the intrafollicular inhibin\/activin\/follistatin axis during human follicular development: relationship to circulating hormone concentrations","volume":"85","author":"Schneyer","year":"2000","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2007.03.086_bib28","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/S0301-2115(02)00193-8","article-title":"Lactate dehydrogenase estimation in follicular fluid: correlation with patient age, follicle size and super ovulation in ART cycles","volume":"105","author":"Adiga","year":"2002","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"10.1016\/j.fertnstert.2007.03.086_bib29","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1016\/S0015-0282(03)01008-2","article-title":"Increased endogenous level of melatonin in preovulatory human follicles does not directly influence progesterone production","volume":"80","author":"Nakamura","year":"2003","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2007.03.086_bib30","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1093\/humrep\/deh096","article-title":"The effects of \u201ccoasting\u201d on follicular fluid concentrations of vascular endothelial growth factor in women at risk of developing ovarian hyperstimulation syndrome","volume":"19","author":"Tozer","year":"2004","journal-title":"Hum Reprod"}],"container-title":["Fertility and Sterility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028207008254?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028207008254?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T07:22:41Z","timestamp":1758007361000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0015028207008254"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,5]]},"references-count":30,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2008,5]]}},"alternative-id":["S0015028207008254"],"URL":"https:\/\/doi.org\/10.1016\/j.fertnstert.2007.03.086","relation":{},"ISSN":["0015-0282"],"issn-type":[{"value":"0015-0282","type":"print"}],"subject":[],"published":{"date-parts":[[2008,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Human granulosa-lutein cell in vitro production of progesterone, inhibin A, inhibin B, and activin A are dependent on follicular size and not the presence of the oocyte","name":"articletitle","label":"Article Title"},{"value":"Fertility and Sterility","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fertnstert.2007.03.086","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}