{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T20:00:20Z","timestamp":1780344020579,"version":"3.54.1"},"reference-count":21,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2008,7,1]],"date-time":"2008-07-01T00:00:00Z","timestamp":1214870400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,7,1]],"date-time":"2008-07-01T00:00:00Z","timestamp":1214870400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,5,27]],"date-time":"2022-05-27T00:00:00Z","timestamp":1653609600000},"content-version":"vor","delay-in-days":5078,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","fertstert.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fertility and Sterility"],"published-print":{"date-parts":[[2008,7]]},"DOI":"10.1016\/j.fertnstert.2007.05.033","type":"journal-article","created":{"date-parts":[[2007,8,14]],"date-time":"2007-08-14T07:23:14Z","timestamp":1187076194000},"page":"17-22","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":81,"title":["Use of the levonorgestrel-releasing intrauterine system in breast cancer patients"],"prefix":"10.1016","volume":"90","author":[{"given":"Xuan Bich","family":"Trinh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wiebren A.A.","family":"Tjalma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amin P.","family":"Makar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guy","family":"Buytaert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joost","family":"Weyler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter A.","family":"van Dam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fertnstert.2007.05.033_bib1","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1016\/S0140-6736(00)03204-9","article-title":"Endometrial protection from tamoxifen-stimulated changes by a levonorgestrel-releasing intrauterine system: a randomised controlled trial","volume":"356","author":"Gardner","year":"2000","journal-title":"Lancet"},{"key":"10.1016\/j.fertnstert.2007.05.033_bib2","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.ejogrb.2005.07.013","article-title":"The thoughts of breast cancer survivors regarding the need for starting hormone replacement therapy","volume":"124","author":"Trinh","year":"2006","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"10.1016\/j.fertnstert.2007.05.033_bib3","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.ejogrb.2005.07.009","article-title":"The thoughts of physicians regarding the need to start hormone replacement therapy in breast cancer survivors","volume":"124","author":"Trinh","year":"2006","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"10.1016\/j.fertnstert.2007.05.033_bib4","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1097\/01.AOG.0000178754.88912.b9","article-title":"Use of the levonorgestrel-releasing intrauterine system and breast cancer","volume":"106","author":"Backman","year":"2005","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.fertnstert.2007.05.033_bib5","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0010-7824(01)00283-9","article-title":"Toxicology of progestogens of implantable contraceptives for women","volume":"65","author":"Jordan","year":"2002","journal-title":"Contraception"},{"key":"10.1016\/j.fertnstert.2007.05.033_bib6","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1097\/01.AOG.0000195269.76793.bb","article-title":"Use of the levonorgestrel-releasing intrauterine system and breast cancer","volume":"107","author":"Tjalma","year":"2006","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.fertnstert.2007.05.033_bib7","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.fertnstert.2005.01.129","article-title":"Effect of 17 beta-estradiol, progesterone, synthetic progestins, tibolone, and tibolone metabolites on vascular endothelial growth factor mRNA in breast cancer cells","volume":"84","author":"Mirkin","year":"2005","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2007.05.033_bib8","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/0960-0760(95)00216-2","article-title":"Effects of two classes of progestagens, pregnane and 19-nortestosterone derivatives, on cell growth of human breast tumor cells: II. T47D cell lines","volume":"55","author":"Schoonen","year":"1995","journal-title":"J Steroid Biochem Mol Biol"},{"key":"10.1016\/j.fertnstert.2007.05.033_bib9","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/0960-0760(95)00215-4","article-title":"Effects of two classes of progestagens, pregnane and 19-nortestosterone derivatives, on cell growth of human breast tumor cells: I. MCF-7 cell lines","volume":"55","author":"Schoonen","year":"1995","journal-title":"J Steroid Biochem Mol Biol"},{"key":"10.1016\/j.fertnstert.2007.05.033_bib10","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/0960-0760(92)90257-J","article-title":"Effects of progestins on the proliferation of estrogen-dependent human breast cancer cells under growth factor-defined conditions","volume":"42","author":"van der","year":"1992","journal-title":"J Steroid Biochem Mol Biol"},{"key":"10.1016\/j.fertnstert.2007.05.033_bib11","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.maturitas.2006.03.010","article-title":"Plasma concentrations of levonorgestrel in patients with an intrauterine progestogen delivery system: do they have any significance?","volume":"55","author":"Trinh","year":"2006","journal-title":"Maturitas"},{"key":"10.1016\/j.fertnstert.2007.05.033_bib12","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.fertnstert.2004.07.961","article-title":"Serum and peritoneal fluid levels of levonorgestrel in women with endometriosis who were treated with an intrauterine contraceptive device containing levonorgestrel","volume":"83","author":"Lockhat","year":"2005","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2007.05.033_bib13","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/0010-7824(90)90035-T","article-title":"Pharmacokinetic and pharmacodynamic studies of levonorgestrel-releasing intrauterine device","volume":"41","author":"Xiao","year":"1990","journal-title":"Contraception"},{"key":"10.1016\/j.fertnstert.2007.05.033_bib14","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/0010-7824(80)90003-7","article-title":"Levonorgestrel plasma concentrations and hormone profiles after insertion and after one year of treatment with a levonorgestrel-IUD","volume":"21","author":"Nilsson","year":"1980","journal-title":"Contraception"},{"key":"10.1016\/j.fertnstert.2007.05.033_bib15","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1111\/j.1471-0528.2002.01167.x","article-title":"Intrauterine 10 microg and 20 microg levonorgestrel systems in postmenopausal women receiving oral oestrogen replacement therapy: clinical, endometrial and metabolic response","volume":"109","author":"Raudaskoski","year":"2002","journal-title":"BJOG"},{"key":"10.1016\/j.fertnstert.2007.05.033_bib16","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1093\/humrep\/deg263","article-title":"Management of a perforated levonorgestrel-medicated intrauterine device\u2014a pharmacokinetic study: case report","volume":"18","author":"Haimov-Kochman","year":"2003","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2007.05.033_bib17","first-page":"423","article-title":"The effect of intrauterine and oral levonorgestrel administration on serum concentrations of sex hormone-binding globulin, insulin and insulin-like growth factor binding protein-1","volume":"78","author":"Pakarinen","year":"1999","journal-title":"Acta Obstet Gynecol Scand"},{"key":"10.1016\/j.fertnstert.2007.05.033_bib18","first-page":"123","article-title":"Bioavailability study with 2 different levonorgestrel-containing drugs in women","volume":"35","author":"Nassr","year":"1997","journal-title":"Int J Clin Pharmacol Ther"},{"key":"10.1016\/j.fertnstert.2007.05.033_bib19","doi-asserted-by":"crossref","first-page":"3243","DOI":"10.1001\/jama.289.24.3243","article-title":"Influence of estrogen plus progestin on breast cancer and mammography in healthy postmenopausal women: the Women's Health Initiative randomized trial","volume":"289","author":"Chlebowski","year":"2003","journal-title":"JAMA"},{"key":"10.1016\/j.fertnstert.2007.05.033_bib20","first-page":"2918","article-title":"Estrogen deprivation causes estradiol hypersensitivity in human breast cancer cells","volume":"80","author":"Masamura","year":"1995","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2007.05.033_bib21","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/j.gyobfe.2006.09.015","article-title":"[Levonorgestrel-releasing intrauterine device (Mirena(R)) and breast cancer: what do we learn from literature for clinical practice?]","volume":"34","author":"Boutet","year":"2006","journal-title":"Gynecol Obstet Fertil"}],"container-title":["Fertility and Sterility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028207012009?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028207012009?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T07:24:00Z","timestamp":1758007440000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0015028207012009"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,7]]},"references-count":21,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,7]]}},"alternative-id":["S0015028207012009"],"URL":"https:\/\/doi.org\/10.1016\/j.fertnstert.2007.05.033","relation":{},"ISSN":["0015-0282"],"issn-type":[{"value":"0015-0282","type":"print"}],"subject":[],"published":{"date-parts":[[2008,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Use of the levonorgestrel-releasing intrauterine system in breast cancer patients","name":"articletitle","label":"Article Title"},{"value":"Fertility and Sterility","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fertnstert.2007.05.033","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}