{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T11:57:10Z","timestamp":1789732630036,"version":"4.0.1"},"reference-count":8,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2008,9,1]],"date-time":"2008-09-01T00:00:00Z","timestamp":1220227200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,9,1]],"date-time":"2008-09-01T00:00:00Z","timestamp":1220227200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,9,12]],"date-time":"2022-09-12T00:00:00Z","timestamp":1662940800000},"content-version":"vor","delay-in-days":5124,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","fertstert.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fertility and Sterility"],"published-print":{"date-parts":[[2008,9]]},"DOI":"10.1016\/j.fertnstert.2007.07.1318","type":"journal-article","created":{"date-parts":[[2008,5,8]],"date-time":"2008-05-08T08:51:41Z","timestamp":1210236701000},"page":"864-865","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["An unreported mutation within protein Z gene is associated with very low protein levels in women with fetal loss"],"prefix":"10.1016","volume":"90","author":[{"given":"Elvira","family":"Grandone","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donatella","family":"Colaizzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filomena","family":"Cappucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa Lucia","family":"D'Ambrosio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gennaro","family":"Vecchione","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Margaglione","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fertnstert.2007.07.1318_bib1","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1055\/s-0037-1616195","article-title":"Protein Z dependent regulation of coagulation","volume":"86","author":"Broze","year":"2001","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.fertnstert.2007.07.1318_bib2","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/0049-3848(95)00089-A","article-title":"Protein Z deficiency: a new cause of bleeding tendency","volume":"79","author":"Kemkes-Matthes","year":"1995","journal-title":"Thromb Res"},{"key":"10.1016\/j.fertnstert.2007.07.1318_bib3","doi-asserted-by":"crossref","first-page":"6734","DOI":"10.1073\/pnas.120081897","article-title":"Prothrombotic phenotype of protein Z deficiency","volume":"97","author":"Yin","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.fertnstert.2007.07.1318_bib4","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0049-3848(02)00181-0","article-title":"Protein Z influences prothrombotic phenotype of factor V Leiden in humans","volume":"106","author":"Kemkes-Matthes","year":"2002","journal-title":"Thromb Res"},{"key":"10.1016\/j.fertnstert.2007.07.1318_bib5","doi-asserted-by":"crossref","first-page":"2606","DOI":"10.1182\/blood.V99.7.2606","article-title":"High frequency of protein Z deficiency in patients with unexplained early fetal loss","volume":"99","author":"Gris","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.fertnstert.2007.07.1318_bib6","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1016\/j.ajog.2005.04.006","article-title":"Protein Z in patients with pregnancy complications","volume":"193","author":"Bretelle","year":"2005","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.fertnstert.2007.07.1318_bib7","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1016\/j.fertnstert.2004.03.049","article-title":"Protein Z levels and unexplained fetal losses","volume":"82","author":"Grandone","year":"2004","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2007.07.1318_bib8","doi-asserted-by":"crossref","first-page":"2417","DOI":"10.1111\/j.1538-7836.2006.02186.x","article-title":"Low protein Z levels and risk of occurrence of deep vein thrombosis","volume":"4","author":"Santacroce","year":"2006","journal-title":"J Thromb Haemost"}],"container-title":["Fertility and Sterility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028207029573?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028207029573?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T07:27:24Z","timestamp":1758007644000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0015028207029573"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,9]]},"references-count":8,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2008,9]]}},"alternative-id":["S0015028207029573"],"URL":"https:\/\/doi.org\/10.1016\/j.fertnstert.2007.07.1318","relation":{},"ISSN":["0015-0282"],"issn-type":[{"value":"0015-0282","type":"print"}],"subject":[],"published":{"date-parts":[[2008,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"An unreported mutation within protein Z gene is associated with very low protein levels in women with fetal loss","name":"articletitle","label":"Article Title"},{"value":"Fertility and Sterility","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fertnstert.2007.07.1318","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}