{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T04:01:08Z","timestamp":1771300868900,"version":"3.50.1"},"reference-count":26,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2008,11,1]],"date-time":"2008-11-01T00:00:00Z","timestamp":1225497600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,11,1]],"date-time":"2008-11-01T00:00:00Z","timestamp":1225497600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,5,27]],"date-time":"2022-05-27T00:00:00Z","timestamp":1653609600000},"content-version":"vor","delay-in-days":4955,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","fertstert.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fertility and Sterility"],"published-print":{"date-parts":[[2008,11]]},"DOI":"10.1016\/j.fertnstert.2007.08.032","type":"journal-article","created":{"date-parts":[[2007,12,13]],"date-time":"2007-12-13T10:56:43Z","timestamp":1197543403000},"page":"1579-1582","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":49,"title":["Systemic methotrexate to treat ectopic pregnancy does not affect ovarian reserve"],"prefix":"10.1016","volume":"90","author":[{"given":"B\u00e1rbara","family":"Oriol","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Barrio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Pacheco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9","family":"Serna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Luis","family":"Zuzuarregui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan A.","family":"Garcia-Velasco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.fertnstert.2007.08.032_bib1","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1016\/S0140-6736(06)68397-9","article-title":"WHO analysis of causes of maternal death: a systematic review","volume":"367","author":"Khan","year":"2006","journal-title":"Lancet"},{"key":"10.1016\/j.fertnstert.2007.08.032_bib2","first-page":"19","article-title":"Impact of assisted reproduction techniques in ectopic pregnancy incidence","volume":"2","author":"Pellicer","year":"1996","journal-title":"Cuad Med Reprod"},{"key":"10.1016\/j.fertnstert.2007.08.032_bib3","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1055\/s-2007-970048","article-title":"Medical therapy for ectopic pregnancy","volume":"25","author":"Lipscomb","year":"2007","journal-title":"Semin Reprod Med"},{"key":"10.1016\/j.fertnstert.2007.08.032_bib4","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0020-7292(99)80046-0","article-title":"ACOG practice bulletin. Medical management of tubal pregnancy. Number 3, December 1998. Clinical management guidelines for obstetrician-gynecologists","volume":"65","author":"American College of Obstetricians and Gynecologists [ACOG]","year":"1999","journal-title":"Int J Gynaecol Obstet"},{"key":"10.1016\/j.fertnstert.2007.08.032_bib5","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1002\/1097-0142(197801)41:1<36::AID-CNCR2820410108>3.0.CO;2-I","article-title":"The clinical pharmacology of methotrexate: new applications of an old drug","volume":"41","author":"Bleyer","year":"1978","journal-title":"Cancer"},{"key":"10.1016\/j.fertnstert.2007.08.032_bib6","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/S0015-0282(16)46349-1","article-title":"Treatment of interstitial ectopic pregnancy with methotrexate: report of a successful case","volume":"37","author":"Tanaka","year":"1982","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2007.08.032_bib7","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/S0015-0282(99)00639-1","article-title":"Serum mullerian-inhibiting substance levels during normal menstrual cycles","volume":"73","author":"Cook","year":"2000","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2007.08.032_bib8","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1093\/humrep\/deh688","article-title":"High reproducibility of serum anti-M\u00fcllerian hormone measurements suggests a multi-staged follicular secretion and strengthens its role in the assessment of ovarian follicular status","volume":"20","author":"Fanchin","year":"2005","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2007.08.032_bib9","first-page":"583","article-title":"Diagnostic accuracy of ultrasound above and below the beta-hCG discriminatory zone","volume":"94","author":"Barnhart","year":"1999","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.fertnstert.2007.08.032_bib10","first-page":"162","article-title":"A method of screening for ectopic pregnancy and its indications","volume":"58","author":"Kadar","year":"1981","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.fertnstert.2007.08.032_bib11","doi-asserted-by":"crossref","first-page":"1974","DOI":"10.1056\/NEJM199912233412604","article-title":"Predictors of success of methotrexate treatment in women with tubal ectopic pregnancies","volume":"341","author":"Lipscomb","year":"1999","journal-title":"N Engl J Med"},{"key":"10.1016\/j.fertnstert.2007.08.032_bib12","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/S0015-0282(03)00545-4","article-title":"Factors that determine discordant outcome from shared oocytes","volume":"80","author":"Garcia-Velasco","year":"2003","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2007.08.032_bib13","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/j.1479-828X.2006.00507.x","article-title":"Fertility preservation in female oncology patients","volume":"46","author":"Stern","year":"2006","journal-title":"Aust NZ J Obstet Gynecol"},{"key":"10.1016\/j.fertnstert.2007.08.032_bib14","doi-asserted-by":"crossref","first-page":"2917","DOI":"10.1200\/JCO.2006.06.5888","article-title":"American Society of Clinical Oncology recommendations on fertility preservation in cancer patients","volume":"24","author":"Lee","year":"2006","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.fertnstert.2007.08.032_bib15","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1016\/j.ygyno.2006.08.003","article-title":"Reproduction beyond cancer: a message of hope for young women","volume":"103","author":"Maltaris","year":"2006","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.fertnstert.2007.08.032_bib16","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/S1472-6483(10)61081-4","article-title":"Anti-M\u00fcllerian hormone: clinical insights into a promising biomarker of ovarian follicular status","volume":"12","author":"Feyereisen","year":"2006","journal-title":"Reprod Biomed Online"},{"key":"10.1016\/j.fertnstert.2007.08.032_bib17","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/j.fertnstert.2004.11.029","article-title":"Serum antimullerian hormone levels best reflect the reproductive decline with age in normal women with proven fertility: a longitudinal study","volume":"83","author":"van Rooij","year":"2005","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2007.08.032_bib18","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1093\/jncimonographs\/lgi026","article-title":"Anti-Mullerian hormone: its role in follicular growth initiation and survival and as an ovarian reserve marker","volume":"34","author":"Themmen","year":"2005","journal-title":"J Natl Cancer Inst Monogr"},{"key":"10.1016\/j.fertnstert.2007.08.032_bib19","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1093\/humrep\/deh669","article-title":"Dynamics of serum anti-Mullerian hormone levels during the luteal phase of controlled ovarian hyperstimulation","volume":"20","author":"Fanchin","year":"2005","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2007.08.032_bib20","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.mce.2003.09.020","article-title":"Hypogonadotropic hypogonadism as a model of post-natal testicular anti-Mullerian hormone secretion in humans","volume":"211","author":"Young","year":"2003","journal-title":"Mol Cell Endocrinol"},{"key":"10.1016\/j.fertnstert.2007.08.032_bib21","article-title":"Increased intrafollicular androgen levels affect human granulosa cell secretion of anti-mullerian hormone and inhibin-B","author":"Andersen","year":"2007","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2007.08.032_bib22","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1111\/j.1365-2265.2005.02336.x","article-title":"Development of a sensitive enzyme immunoassay for anti-Mullerian hormone and the evaluation of potential clinical applications in males and females","volume":"63","author":"Al-Qahtani","year":"2006","journal-title":"Clin Endocrinol"},{"key":"10.1016\/j.fertnstert.2007.08.032_bib23","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1055\/s-2007-970052","article-title":"Reproductive performance after ectopic pregnancy","volume":"25","author":"Buster","year":"2007","journal-title":"Semin Reprod Med"},{"key":"10.1016\/j.fertnstert.2007.08.032_bib24","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/S0015-0282(97)80064-7","article-title":"Current status of surgical and non-surgical treatment of ectopic pregnancy","volume":"67","author":"Yao","year":"1997","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2007.08.032_bib25","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/S0889-8545(05)70162-5","article-title":"An update on the medical treatment of ectopic pregnancy","volume":"27","author":"Barnhart","year":"2000","journal-title":"Obstet Gynecol Clin North Am"},{"key":"10.1016\/j.fertnstert.2007.08.032_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.fertnstert.2007.01.064","article-title":"Does methotrexate treatment of ectopic pregnancy influence the patient's performance during a subsequent in vitro fertilization\/embryo transfer cycle?","author":"Orvieto","year":"2007","journal-title":"Fertil Steril"}],"container-title":["Fertility and Sterility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028207031755?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028207031755?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T07:29:01Z","timestamp":1758007741000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0015028207031755"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,11]]},"references-count":26,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2008,11]]}},"alternative-id":["S0015028207031755"],"URL":"https:\/\/doi.org\/10.1016\/j.fertnstert.2007.08.032","relation":{},"ISSN":["0015-0282"],"issn-type":[{"value":"0015-0282","type":"print"}],"subject":[],"published":{"date-parts":[[2008,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Systemic methotrexate to treat ectopic pregnancy does not affect ovarian reserve","name":"articletitle","label":"Article Title"},{"value":"Fertility and Sterility","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fertnstert.2007.08.032","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}