{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:46:35Z","timestamp":1772120795708,"version":"3.50.1"},"reference-count":25,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2008,11,1]],"date-time":"2008-11-01T00:00:00Z","timestamp":1225497600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,11,1]],"date-time":"2008-11-01T00:00:00Z","timestamp":1225497600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,5,27]],"date-time":"2022-05-27T00:00:00Z","timestamp":1653609600000},"content-version":"vor","delay-in-days":4955,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","fertstert.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fertility and Sterility"],"published-print":{"date-parts":[[2008,11]]},"DOI":"10.1016\/j.fertnstert.2007.09.052","type":"journal-article","created":{"date-parts":[[2008,1,3]],"date-time":"2008-01-03T10:37:03Z","timestamp":1199356623000},"page":"1769-1773","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":47,"title":["Does varicocele grade determine extent of alteration to spermatogenesis in adolescents?"],"prefix":"10.1016","volume":"90","author":[{"given":"Marcos Mitsuyoshi","family":"Mori","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo Pimenta","family":"Bertolla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renato","family":"Fraietta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valdemar","family":"Ortiz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agnaldo Pereira","family":"Cedenho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.fertnstert.2007.09.052_bib1","series-title":"Laboratory manual for the examination of human semen and sperm-cervical mucus interaction","author":"World Health Organization","year":"1999"},{"key":"10.1016\/j.fertnstert.2007.09.052_bib2","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/S0015-0282(16)55809-9","article-title":"Loss of fertility in men with varicocele","volume":"59","author":"Gorelick","year":"1993","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2007.09.052_bib3","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/0090-4295(93)90268-F","article-title":"Varicocele: a progressive or static lesion?","volume":"42","author":"Witt","year":"1993","journal-title":"Urology"},{"key":"10.1016\/j.fertnstert.2007.09.052_bib4","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.fertnstert.2003.08.010","article-title":"Varicocele: a bilateral disease","volume":"81","author":"Gat","year":"2004","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2007.09.052_bib5","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1016\/S0015-0282(16)55089-4","article-title":"The influence of varicocele on parameters of fertility in a large group of men presenting to infertility clinics","volume":"57","author":"World Health Organization","year":"1992","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2007.09.052_bib6","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1016\/S0022-5347(05)68818-0","article-title":"Varicocele is associated with elevated spermatozoal reactive oxygen species production and diminished seminal plasma antioxidant capacity","volume":"161","author":"Hendin","year":"1999","journal-title":"J Urol"},{"key":"10.1016\/j.fertnstert.2007.09.052_bib7","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1016\/S0015-0282(03)02211-8","article-title":"Evaluation of nuclear DNA damage in spermatozoa from infertile men with varicocele","volume":"80","author":"Saleh","year":"2003","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2007.09.052_bib8","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1111\/j.1439-0272.1976.tb01645.x","article-title":"Prevention of fertility disorders by detection and treatment of varicocele at school and college age","volume":"8","author":"Steeno","year":"1976","journal-title":"Andrologia"},{"key":"10.1016\/j.fertnstert.2007.09.052_bib9","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/S0015-0282(16)35765-X","article-title":"Seminal cytology in the presence of varicocele","volume":"16","author":"MacLeod","year":"1965","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2007.09.052_bib10","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/j.fertnstert.2005.08.032","article-title":"Sperm nuclear DNA fragmentation in adolescents with varicocele","volume":"85","author":"Bertolla","year":"2006","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2007.09.052_bib11","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1016\/j.fertnstert.2006.05.030","article-title":"Expression of the HSPA2 gene in ejaculated spermatozoa from adolescents with and without varicocele","volume":"86","author":"Lima","year":"2006","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2007.09.052_bib12","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/S0015-0282(16)37684-1","article-title":"Varicocele size and results of varicocelectomy in selected subfertile men with varicocele","volume":"21","author":"Dubin","year":"1970","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2007.09.052_bib13","doi-asserted-by":"crossref","first-page":"29","DOI":"10.3109\/00016347509158662","article-title":"The effect on fertility of ligation of the left spermatic vein in men without clinical signs of varicocele","volume":"54","author":"Fogh-Andersen","year":"1975","journal-title":"Acta Obstet Gynecol Scand"},{"key":"10.1016\/j.fertnstert.2007.09.052_bib14","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/S0022-5347(17)36203-1","article-title":"Relationship between varicocele size and response to varicocelectomy","volume":"149","author":"Steckel","year":"1993","journal-title":"J Urol"},{"key":"10.1016\/j.fertnstert.2007.09.052_bib15","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1016\/S0022-5347(01)66245-1","article-title":"Seminal improvement following repair of ultrasound detected subclinical varicoceles","volume":"155","author":"Jarow","year":"1996","journal-title":"J Urol"},{"key":"10.1016\/j.fertnstert.2007.09.052_bib16","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1016\/S0015-0282(16)49891-2","article-title":"Sperm morphology features as a prognostic factor in vitro fertilization","volume":"46","author":"Kruger","year":"1986","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2007.09.052_bib17","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/S0015-0282(16)57306-3","article-title":"Controlled trial of high spermatic vein ligation for varicocele in infertile men","volume":"63","author":"Madgar","year":"1995","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2007.09.052_bib18","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/S0094-0143(21)00624-8","article-title":"Treatment outcome after varicocelectomy. A critical analysis","volume":"21","author":"Schlesinger","year":"1994","journal-title":"Urol Clin North Am"},{"key":"10.1016\/j.fertnstert.2007.09.052_bib19","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1159\/000480831","article-title":"Correlation between semen parameters and retrograde flow into the pampiniform plexus before and after varicocelectomy","volume":"32","author":"Segenreich","year":"1997","journal-title":"Eur Urol"},{"key":"10.1016\/j.fertnstert.2007.09.052_bib20","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1093\/humupd\/7.1.65","article-title":"Varicocele treatment in the light of evidence-based andrology","volume":"7","author":"Kamischke","year":"2001","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.fertnstert.2007.09.052_bib21","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.fertnstert.2006.12.008","article-title":"Reassessing the value of varicocelectomy as a treatment for male subfertility with a new meta-analysis","volume":"88","author":"Marmar","year":"2007","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2007.09.052_bib22","first-page":"S142","article-title":"The Male Infertility Best Practice Policy Committee of the American Urological Association; Practice Committee of the American Society for Reproductive Medicine. Report on varicocele and infertility","volume":"82","year":"2004","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2007.09.052_bib23","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1093\/humupd\/7.5.473","article-title":"Pathophysiology of varicoceles in male infertility","volume":"7","author":"Naughton","year":"2001","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.fertnstert.2007.09.052_bib24","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/0090-4295(93)90510-H","article-title":"Varicoceles: effect on testicular volume in prepubertal and pubertal males","volume":"41","author":"Sawczuk","year":"1993","journal-title":"Urology"},{"key":"10.1016\/j.fertnstert.2007.09.052_bib25","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1016\/S0891-5849(01)00536-6","article-title":"Oxidative damage to proteins and decrease of antioxidant capacity in patients with varicocele","volume":"30","author":"Chen","year":"2001","journal-title":"Free Radic Biol Med"}],"container-title":["Fertility and Sterility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001502820703748X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001502820703748X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T07:26:26Z","timestamp":1758007586000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S001502820703748X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,11]]},"references-count":25,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2008,11]]}},"alternative-id":["S001502820703748X"],"URL":"https:\/\/doi.org\/10.1016\/j.fertnstert.2007.09.052","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1097952.556094","asserted-by":"object"}]},"ISSN":["0015-0282"],"issn-type":[{"value":"0015-0282","type":"print"}],"subject":[],"published":{"date-parts":[[2008,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Does varicocele grade determine extent of alteration to spermatogenesis in adolescents?","name":"articletitle","label":"Article Title"},{"value":"Fertility and Sterility","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fertnstert.2007.09.052","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}