{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T06:10:58Z","timestamp":1762150258598,"version":"build-2065373602"},"reference-count":46,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2009,2,1]],"date-time":"2009-02-01T00:00:00Z","timestamp":1233446400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,2,1]],"date-time":"2009-02-01T00:00:00Z","timestamp":1233446400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,5,27]],"date-time":"2022-05-27T00:00:00Z","timestamp":1653609600000},"content-version":"vor","delay-in-days":4863,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001868","name":"National Science Council","doi-asserted-by":"publisher","award":["NSC-96-2314-B-040-002"],"award-info":[{"award-number":["NSC-96-2314-B-040-002"]}],"id":[{"id":"10.13039\/501100001868","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","fertstert.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fertility and Sterility"],"published-print":{"date-parts":[[2009,2]]},"DOI":"10.1016\/j.fertnstert.2007.12.076","type":"journal-article","created":{"date-parts":[[2008,3,11]],"date-time":"2008-03-11T09:17:11Z","timestamp":1205227031000},"page":"549-555","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["Imbalanced serum concentration between cathepsin B and cystatin C in patients with pelvic inflammatory disease"],"prefix":"10.1016","volume":"91","author":[{"given":"Hsiu-Ting","family":"Tsai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Po-Hui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi-Torng","family":"Tee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Long-Yau","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yih-Shou","family":"Hsieh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shun-Fa","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.fertnstert.2007.12.076_bib1","doi-asserted-by":"crossref","first-page":"9842","DOI":"10.1074\/jbc.273.16.9842","article-title":"Lysosomal enzyme trafficking between phagosomes, endosomes, and lysosomes in J774 macrophages. Enrichment of cathepsin H in early endosomes","volume":"273","author":"Claus","year":"1998","journal-title":"J Biol Chem"},{"key":"10.1016\/j.fertnstert.2007.12.076_bib2","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1111\/j.1749-6632.1991.tb17009.x","article-title":"Role of enzyme receptors and inhibitors in regulating proteolytic activities of macrophages","volume":"624","author":"Chapman","year":"1991","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.fertnstert.2007.12.076_bib3","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1016\/j.humpath.2005.06.021","article-title":"Clinicopathologic significance of cystatin C expression in gliomas","volume":"36","author":"Nakabayashi","year":"2005","journal-title":"Hum Pathol"},{"key":"10.1016\/j.fertnstert.2007.12.076_bib4","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1083\/jcb.153.5.999","article-title":"Cathepsin B acts as a dominant execution protease in tumor cell apoptosis induced by tumor necrosis factor","volume":"153","author":"Foghsgaard","year":"2001","journal-title":"J Cell Biol"},{"key":"10.1016\/j.fertnstert.2007.12.076_bib5","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0009-8981(03)00023-8","article-title":"Cathepsin B and H activities and cystatin C concentrations in cerebrospinal fluid from patients with leptomeningeal metastasis","volume":"329","author":"Nagai","year":"2003","journal-title":"Clin Chim Acta"},{"key":"10.1016\/j.fertnstert.2007.12.076_bib6","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.1212\/WNL.55.12.1828","article-title":"Cystatin C and cathepsin B in CSF from patients with inflammatory neurologic diseases","volume":"55","author":"Nagai","year":"2000","journal-title":"Neurology"},{"key":"10.1016\/j.fertnstert.2007.12.076_bib7","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1159\/000227666","article-title":"Lysosomal cathepsins B and L and Stefin A blood levels in patients with hepatocellular carcinoma and\/or liver cirrhosis: potential clinical implications","volume":"54","author":"Leto","year":"1997","journal-title":"Oncology"},{"key":"10.1016\/j.fertnstert.2007.12.076_bib8","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1002\/j.1939-4640.2004.tb02827.x","article-title":"Cystatin C is highly expressed in the human male reproductive system","volume":"25","author":"Jiborn","year":"2004","journal-title":"J Androl"},{"key":"10.1016\/j.fertnstert.2007.12.076_bib9","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1042\/bj2730621","article-title":"Role of the N-terminal segment in the inhibition of human cysteine proteinases and in its inactivation by leucocyte elastase","volume":"273","author":"Abrahamson","year":"1991","journal-title":"Biochem J"},{"key":"10.1016\/j.fertnstert.2007.12.076_bib10","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1042\/bj2680287","article-title":"Structure and expression of the human cystatin C gene","volume":"268","author":"Abrahamson","year":"1990","journal-title":"Biochem J"},{"key":"10.1016\/j.fertnstert.2007.12.076_bib11","doi-asserted-by":"crossref","first-page":"1912","DOI":"10.1084\/jem.166.6.1912","article-title":"Constitutive secretion of cystatin C (gamma-trace) by monocytes and macrophages and its downregulation after stimulation","volume":"166","author":"Warfel","year":"1987","journal-title":"J Exp Med"},{"key":"10.1016\/j.fertnstert.2007.12.076_bib12","doi-asserted-by":"crossref","first-page":"11282","DOI":"10.1016\/S0021-9258(18)67380-6","article-title":"Isolation of six cysteine proteinase inhibitors from human urine. Their physicochemical and enzyme kinetic properties and concentrations in biological fluids","volume":"261","author":"Abrahamson","year":"1986","journal-title":"J Biol Chem"},{"key":"10.1016\/j.fertnstert.2007.12.076_bib13","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/0014-4827(90)90272-C","article-title":"Modulation of phagocytosis-associated respiratory burst by human cystatin C: role of the N-terminal tetrapeptide Lys-Pro-Pro-Arg","volume":"188","author":"Leung-Tack","year":"1990","journal-title":"Exp Cell Res"},{"key":"10.1016\/j.fertnstert.2007.12.076_bib14","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.brainres.2005.10.063","article-title":"Neuronal cell death induced by cystatin C in vivo and in cultured human CNS neurons is inhibited with cathepsin B","volume":"1066","author":"Nagai","year":"2005","journal-title":"Brain Res"},{"key":"10.1016\/j.fertnstert.2007.12.076_bib15","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1002\/ana.20786","article-title":"Cleavage of cystatin C in the cerebrospinal fluid of patients with multiple sclerosis","volume":"59","author":"Irani","year":"2006","journal-title":"Ann Neurol"},{"key":"10.1016\/j.fertnstert.2007.12.076_bib16","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1093\/molehr\/gah172","article-title":"Role of cathepsins and cystatins in patients with recurrent miscarriage","volume":"11","author":"Nakanishi","year":"2005","journal-title":"Mol Hum Reprod"},{"key":"10.1016\/j.fertnstert.2007.12.076_bib17","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.cccn.2003.11.011","article-title":"Increased cystatin C serum concentrations in patients with hepatic diseases of various severities","volume":"341","author":"Chu","year":"2004","journal-title":"Clin Chim Acta"},{"key":"10.1016\/j.fertnstert.2007.12.076_bib18","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.neuint.2006.12.006","article-title":"6-Hydroxydopamine induces cystatin C-mediated cysteine protease suppression and cathepsin D activation","volume":"50","author":"Lee","year":"2007","journal-title":"Neurochem Int"},{"key":"10.1016\/j.fertnstert.2007.12.076_bib19","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1007\/s11064-006-9183-y","article-title":"Induced expression of cathepsins and cystatin C in a murine model of demyelination","volume":"32","author":"Ma","year":"2007","journal-title":"Neurochem Res"},{"key":"10.1016\/j.fertnstert.2007.12.076_bib20","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.neuro.2005.11.011","article-title":"Enhanced cystatin C and lysosomal protease expression following 6-hydroxydopamine exposure","volume":"27","author":"Lee","year":"2006","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.fertnstert.2007.12.076_bib21","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.exer.2006.03.009","article-title":"Regulation of cysteine cathepsin expression by oxidative stress in the retinal pigment epithelium\/choroid of the mouse","volume":"83","author":"Alizadeh","year":"2006","journal-title":"Exp Eye Res"},{"key":"10.1016\/j.fertnstert.2007.12.076_bib22","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1200\/JCO.2005.03.3399","article-title":"Tumor transcriptome reveals the predictive and prognostic impact of lysosomal protease inhibitors in non-small-cell lung cancer","volume":"24","author":"Petty","year":"2006","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.fertnstert.2007.12.076_bib23","doi-asserted-by":"crossref","first-page":"8608","DOI":"10.1158\/0008-5472.CAN-05-1572","article-title":"Reduction of experimental human fibrosarcoma lung metastasis in mice by adenovirus-mediated cystatin C overexpression in the host","volume":"65","author":"Kopitz","year":"2005","journal-title":"Cancer Res"},{"key":"10.1016\/j.fertnstert.2007.12.076_bib24","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1164\/rccm.200503-425OC","article-title":"Imbalance between cysteine proteases and inhibitors in a baboon model of bronchopulmonary dysplasia","volume":"173","author":"Altiok","year":"2006","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.fertnstert.2007.12.076_bib25","first-page":"858","article-title":"Pelvic inflammatory disease","volume":"35","author":"Dayan","year":"2006","journal-title":"Aust Fam Physician"},{"key":"10.1016\/j.fertnstert.2007.12.076_bib26","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1097\/01.gco.0000242952.87125.69","article-title":"Pelvic inflammatory disease in adolescents","volume":"18","author":"Gray-Swain","year":"2006","journal-title":"Curr Opin Obstet Gynecol"},{"key":"10.1016\/j.fertnstert.2007.12.076_bib27","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1172\/JCI200317740","article-title":"Cathepsin B inactivation attenuates hepatic injury and fibrosis during cholestasis","volume":"112","author":"Canbay","year":"2003","journal-title":"J Clin Invest"},{"key":"10.1016\/j.fertnstert.2007.12.076_bib28","first-page":"732","article-title":"The practice guideline \u201cpelvic inflammatory disease.\u201d 1st rev. ed.","volume":"151","author":"Kroon","year":"2007","journal-title":"Ned Tijdschr Geneeskd"},{"key":"10.1016\/j.fertnstert.2007.12.076_bib29","first-page":"1","article-title":"Sexually transmitted diseases treatment guidelines, 2006","volume":"55","author":"Workowski","year":"2006","journal-title":"MMWR Recomm Rep"},{"key":"10.1016\/j.fertnstert.2007.12.076_bib30","first-page":"63","article-title":"C-reactive protein in the evaluation of antibiotic therapy for pelvic infection","volume":"25","author":"Angerman","year":"1980","journal-title":"J Reprod Med"},{"key":"10.1016\/j.fertnstert.2007.12.076_bib31","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1016\/0002-9378(86)90324-8","article-title":"Predicting acute pelvic inflammatory disease: a multivariate analysis","volume":"155","author":"Hadgu","year":"1986","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.fertnstert.2007.12.076_bib32","doi-asserted-by":"crossref","first-page":"2203","DOI":"10.1016\/S0002-9440(10)63777-7","article-title":"Pivotal role of cathepsin K in lung fibrosis","volume":"164","author":"Buhling","year":"2004","journal-title":"Am J Pathol"},{"key":"10.1016\/j.fertnstert.2007.12.076_bib33","doi-asserted-by":"crossref","first-page":"5404","DOI":"10.4049\/jimmunol.172.9.5405","article-title":"Cathepsin-dependent apoptosis triggered by supraoptimal activation of T lymphocytes: a possible mechanism of high dose tolerance","volume":"172","author":"Michallet","year":"2004","journal-title":"J Immunol"},{"key":"10.1016\/j.fertnstert.2007.12.076_bib34","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1172\/JCI10458","article-title":"Inducible targeting of IL-13 to the adult lung causes matrix metalloproteinase- and cathepsin-dependent emphysema","volume":"106","author":"Zheng","year":"2000","journal-title":"J Clin Invest"},{"key":"10.1016\/j.fertnstert.2007.12.076_bib35","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1084\/jem.192.11.1587","article-title":"Interferon gamma induction of pulmonary emphysema in the adult murine lung","volume":"192","author":"Wang","year":"2000","journal-title":"J Exp Med"},{"key":"10.1016\/j.fertnstert.2007.12.076_bib36","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1042\/BC20040512","article-title":"Active cathepsins B, H, K, L and S in human inflammatory bronchoalveolar lavage fluids","volume":"98","author":"Serveau-Avesque","year":"2006","journal-title":"Biol Cell"},{"key":"10.1016\/j.fertnstert.2007.12.076_bib37","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.bbadis.2005.10.005","article-title":"Cysteine cathepsins in human silicotic bronchoalveolar lavage fluids","author":"Perdereau","year":"2006","journal-title":"Biochim Biophys Acta"},{"issue":"7","key":"10.1016\/j.fertnstert.2007.12.076_bib38","first-page":"1265","article-title":"Relationship between cathepsin B and thrombin in rheumatoid arthritis","volume":"31","author":"Mishiro","year":"2004","journal-title":"J Rheumatol"},{"key":"10.1016\/j.fertnstert.2007.12.076_bib39","doi-asserted-by":"crossref","first-page":"4186","DOI":"10.1128\/JVI.02601-06","article-title":"Cytosolic activation of cathepsins mediates parvovirus H-1-induced killing of cisplatin and TRAIL-resistant glioma cells","volume":"81","author":"Di Piazza","year":"2007","journal-title":"J Virol"},{"key":"10.1016\/j.fertnstert.2007.12.076_bib40","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1172\/JCI9914","article-title":"Cathepsin B contributes to TNF-alpha-mediated hepatocyte apoptosis by promoting mitochondrial release of cytochrome c","volume":"106","author":"Guicciardi","year":"2000","journal-title":"J Clin Invest"},{"key":"10.1016\/j.fertnstert.2007.12.076_bib41","doi-asserted-by":"crossref","first-page":"3643","DOI":"10.1128\/IAI.00012-06","article-title":"Infection of human fallopian tube epithelial cells with Neisseria gonorrhoeae protects cells from tumor necrosis factor alpha-induced apoptosis","volume":"74","author":"Morales","year":"2006","journal-title":"Infect Immun"},{"key":"10.1016\/j.fertnstert.2007.12.076_bib42","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1111\/j.1471-0528.1995.tb11294.x","article-title":"Clinical, laparoscopic and microbiological findings in acute salpingitis: report on a United Kingdom cohort","volume":"102","author":"Bevan","year":"1995","journal-title":"Br J Obstet Gynaecol"},{"key":"10.1016\/j.fertnstert.2007.12.076_bib43","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0165-0378(02)00019-0","article-title":"The innate and early immune response to pathogen challenge in the female genital tract and the pivotal role of epithelial cells","volume":"57","author":"Quayle","year":"2002","journal-title":"J Reprod Immunol"},{"key":"10.1016\/j.fertnstert.2007.12.076_bib44","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1097\/00007435-199903000-00007","article-title":"Gonococcal infection of human fallopian tube mucosa in organ culture: relationship of mucosal tissue TNF-alpha concentration to sloughing of ciliated cells","volume":"26","author":"McGee","year":"1999","journal-title":"Sex Transm Dis"},{"key":"10.1016\/j.fertnstert.2007.12.076_bib45","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1093\/ndt\/gfl744","article-title":"Association of cystatin C and estimated GFR with inflammatory biomarkers: the Heart and Soul Study","volume":"22","author":"Singh","year":"2007","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.fertnstert.2007.12.076_bib46","doi-asserted-by":"crossref","first-page":"1416.e25","DOI":"10.1016\/j.amjmed.2005.07.060","article-title":"Cystatin-C and inflammatory markers in the ambulatory elderly","volume":"118","author":"Shlipak","year":"2005","journal-title":"Am J Med"}],"container-title":["Fertility and Sterility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028207043853?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028207043853?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T06:07:58Z","timestamp":1762150078000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0015028207043853"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,2]]},"references-count":46,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2009,2]]}},"alternative-id":["S0015028207043853"],"URL":"https:\/\/doi.org\/10.1016\/j.fertnstert.2007.12.076","relation":{},"ISSN":["0015-0282"],"issn-type":[{"type":"print","value":"0015-0282"}],"subject":[],"published":{"date-parts":[[2009,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Imbalanced serum concentration between cathepsin B and cystatin C in patients with pelvic inflammatory disease","name":"articletitle","label":"Article Title"},{"value":"Fertility and Sterility","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fertnstert.2007.12.076","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}