{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T10:40:24Z","timestamp":1784371224623,"version":"3.55.0"},"reference-count":14,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2009,4,1]],"date-time":"2009-04-01T00:00:00Z","timestamp":1238544000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,4,1]],"date-time":"2009-04-01T00:00:00Z","timestamp":1238544000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,5,27]],"date-time":"2022-05-27T00:00:00Z","timestamp":1653609600000},"content-version":"vor","delay-in-days":4804,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","fertstert.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fertility and Sterility"],"published-print":{"date-parts":[[2009,4]]},"DOI":"10.1016\/j.fertnstert.2008.03.042","type":"journal-article","created":{"date-parts":[[2008,6,14]],"date-time":"2008-06-14T04:32:43Z","timestamp":1213417963000},"page":"1347-1350","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"special_numbering":"S","title":["Isopropanolic Cimicifuga racemosa is favorable on bone markers but neutral on an osteoblastic cell line"],"prefix":"10.1016","volume":"91","author":[{"given":"Miguel Angel","family":"Garc\u00eda-P\u00e9rez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bego\u00f1a","family":"Pineda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Hermenegildo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan J.","family":"Tar\u00edn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Cano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fertnstert.2008.03.042_bib1","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1001\/jama.288.7.872","article-title":"Postmenopausal hormone replacement therapy: scientific review","volume":"288","author":"Nelson","year":"2002","journal-title":"JAMA"},{"key":"10.1016\/j.fertnstert.2008.03.042_bib2","doi-asserted-by":"crossref","first-page":"177","DOI":"10.2165\/00024677-200504030-00006","article-title":"Black cohosh (Actaea\/Cimicifuga racemosa): review of the clinical data for safety and efficacy in menopausal symptoms","volume":"4","author":"Mahady","year":"2005","journal-title":"Treat Endocrinol"},{"key":"10.1016\/j.fertnstert.2008.03.042_bib3","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.maturitas.2004.07.007","article-title":"Effects of estradiol-17\u03b2, testosterone and a black cohosh preparation on bone and prostate in orchidectomized rats","volume":"51","author":"Seidlova-Wuttke","year":"2005","journal-title":"Maturitas"},{"key":"10.1016\/j.fertnstert.2008.03.042_bib4","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1097\/01.gme.0000174470.44822.57","article-title":"Effects of black cohosh (Cimicifuga racemosa) on bone turnover, vaginal mucosa, and various blood parameters in postmenopausal women: a double-blind, placebo-controlled, and conjugated estrogens-controlled study","volume":"13","author":"Wuttke","year":"2006","journal-title":"Menopause"},{"key":"10.1016\/j.fertnstert.2008.03.042_bib5","doi-asserted-by":"crossref","first-page":"2036","DOI":"10.1359\/JBMR.050716","article-title":"Isopropanolic extract of black cohosh stimulates osteoprotegerin production by human osteoblasts","volume":"20","author":"Viereck","year":"2005","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.fertnstert.2008.03.042_bib6","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1016\/j.chembiol.2007.06.010","article-title":"A triterpene glycoside from black cohosh that inhibits osteoclastogenesis by modulating RANKL and TNF\u03b1 signaling pathways","volume":"14","author":"Qiu","year":"2007","journal-title":"Chem Biol"},{"key":"10.1016\/j.fertnstert.2008.03.042_bib7","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1080\/09513590600624291","article-title":"Similar efficacy of low and standard doses of transdermal estradiol in controlling bone turnover in postmenopausal women","volume":"22","author":"Garc\u00eda-P\u00e9rez","year":"2006","journal-title":"Gynecol Endocrinol"},{"key":"10.1016\/j.fertnstert.2008.03.042_bib8","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1016\/j.fertnstert.2005.05.072","article-title":"Therapeutic dosages of raloxifene do not modify myeloperoxidase and F2\u03b1-isoprostane levels in postmenopausal women","volume":"84","author":"Oviedo","year":"2005","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2008.03.042_bib9","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1359\/jbmr.060512","article-title":"Differentiation-inducing factor-1 alters canonical Wnt signaling and suppresses alkaline phosphatase expression in osteoblast-like cell lines","volume":"21","author":"Matsuzaki","year":"2006","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.fertnstert.2008.03.042_bib10","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1177\/039463200601900410","article-title":"Estrogen receptor agonists and immune system in ovariectomized mice","volume":"19","author":"Garcia-Perez","year":"2006","journal-title":"Int J Immunopathol Pharmacol"},{"key":"10.1016\/j.fertnstert.2008.03.042_bib11","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/S0015-0282(16)58506-9","article-title":"Hormone replacement therapy modifies the capacity of plasma and serum to regulate prostacyclin and endothelin-1 production in human vascular endothelial cells","volume":"66","author":"Mikkola","year":"1996","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2008.03.042_bib12","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1016\/j.fertnstert.2004.11.075","article-title":"Raloxifene promotes prostacyclin release in human endothelial cells through a mechanism that involves cyclooxygenase-1 and -2","volume":"83","author":"Oviedo","year":"2005","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2008.03.042_bib13","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1089\/152460902753645308","article-title":"Physiological investigation of a unique extract of black cohosh (Cimicifugae racemosae rhizoma): a 6-month clinical study demonstrates no systemic estrogenic effect","volume":"11","author":"Liske","year":"2002","journal-title":"J Womens Health Gend Based Med"},{"key":"10.1016\/j.fertnstert.2008.03.042_bib14","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0960-0760(01)00178-9","article-title":"Antiestrogenic activities of Cimicifuga racemosa extracts","volume":"80","author":"Zierau","year":"2002","journal-title":"J Steroid Biochem Mol Biol"}],"container-title":["Fertility and Sterility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028208007097?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028208007097?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T07:34:11Z","timestamp":1758008051000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0015028208007097"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,4]]},"references-count":14,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2009,4]]}},"alternative-id":["S0015028208007097"],"URL":"https:\/\/doi.org\/10.1016\/j.fertnstert.2008.03.042","relation":{},"ISSN":["0015-0282"],"issn-type":[{"value":"0015-0282","type":"print"}],"subject":[],"published":{"date-parts":[[2009,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Isopropanolic Cimicifuga racemosa is favorable on bone markers but neutral on an osteoblastic cell line","name":"articletitle","label":"Article Title"},{"value":"Fertility and Sterility","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fertnstert.2008.03.042","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}