{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T10:32:51Z","timestamp":1773916371945,"version":"3.50.1"},"reference-count":24,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2009,7,1]],"date-time":"2009-07-01T00:00:00Z","timestamp":1246406400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,7,1]],"date-time":"2009-07-01T00:00:00Z","timestamp":1246406400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,9,12]],"date-time":"2022-09-12T00:00:00Z","timestamp":1662940800000},"content-version":"vor","delay-in-days":4821,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["30530740\/C030304"],"award-info":[{"award-number":["30530740\/C030304"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","fertstert.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fertility and Sterility"],"published-print":{"date-parts":[[2009,7]]},"DOI":"10.1016\/j.fertnstert.2008.04.068","type":"journal-article","created":{"date-parts":[[2008,8,4]],"date-time":"2008-08-04T10:03:39Z","timestamp":1217844219000},"page":"301-305","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":38,"title":["Proportional change of CD4+CD25+ regulatory T cells after lymphocyte therapy in unexplained recurrent spontaneous abortion patients"],"prefix":"10.1016","volume":"92","author":[{"given":"Hui","family":"Yang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lihua","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen","family":"Di","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aiming","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guangjie","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ke","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qide","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.fertnstert.2008.04.068_bib1","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1093\/humupd\/2.2.118","article-title":"Reproductive failure due to spontaneous abortion and recurrent miscarriage","volume":"2","author":"Bulletti","year":"1996","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.fertnstert.2008.04.068_bib2","first-page":"193","article-title":"The use of intravenous immunoglobulin in sine causa or alloimmune recurrent spontaneous abortion (RSA)","volume":"42","author":"Patriarca","year":"2000","journal-title":"Panminerva Med"},{"key":"10.1016\/j.fertnstert.2008.04.068_bib3","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/j.fertnstert.2004.12.018","article-title":"Evidence-based investigations and treatments of recurrent pregnancy loss","volume":"83","author":"Christiansen","year":"2005","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2008.04.068_bib4","first-page":"320","article-title":"Some immunological and endocrinological problems raised by the evolution of viviparity in vertebrates","volume":"44","author":"Medawar","year":"1953","journal-title":"Symp Soc Exp Biol"},{"key":"10.1016\/j.fertnstert.2008.04.068_bib5","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.4049\/jimmunol.167.3.1245","article-title":"CD4+CD25high regulatory cells in human peripheral blood","volume":"167","author":"Baecher-Allan","year":"2001","journal-title":"J Immunol"},{"key":"10.1016\/j.fertnstert.2008.04.068_bib6","first-page":"143","article-title":"Immunologic diagnosis and treatment in the cases of unexplained habitual abortion","volume":"28","author":"Lin","year":"1993","journal-title":"Zhonghua Fu Chan Ke Za Zhi"},{"key":"10.1016\/j.fertnstert.2008.04.068_bib7","first-page":"1063","article-title":"The influence of paternal lymphocytes immunization on percentage of peripheral blood CD16+\/CD56+ cells in women with primary recurrent spontaneous abortion","volume":"72","author":"Szpakowski","year":"2001","journal-title":"Ginekol Pol"},{"key":"10.1016\/j.fertnstert.2008.04.068_bib8","first-page":"288","article-title":"Influence of paternal lymphocyte immunization on the selected subpopulations of peripheral blood lymphocytes in women with recurrent spontaneous abortions of unknown etiology","volume":"74","author":"Szpakowski","year":"2003","journal-title":"Ginekol Pol"},{"key":"10.1016\/j.fertnstert.2008.04.068_bib9","first-page":"408","article-title":"Study on changes of serum T helper cell type 1 and 2 cytokines after active immunotherapy in women with unexplained habitual abortion","volume":"36","author":"Qiu","year":"2001","journal-title":"Zhonghua Fu Chan Ke Za Zhi"},{"key":"10.1016\/j.fertnstert.2008.04.068_bib10","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1084\/jem.20020090","article-title":"CD4(+)CD25(+) immunoregulatory T cells: new therapeutics for graft-versus-host disease","volume":"196","author":"Cohen","year":"2002","journal-title":"J Exp Med"},{"key":"10.1016\/j.fertnstert.2008.04.068_bib11","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/S0002-9440(10)62302-4","article-title":"Abnormal T-cell reactivity against paternal antigens in spontaneous abortion: adoptive transfer of pregnancy-induced CD4+CD25+ T regulatory cells prevents fetal rejection in a murine abortion model","volume":"166","author":"Zenclussen","year":"2005","journal-title":"Am J Pathol"},{"key":"10.1016\/j.fertnstert.2008.04.068_bib12","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1093\/molehr\/gah044","article-title":"Decidual and peripheral blood CD4+CD25+ regulatory T cells in early pregnancy subjects and spontaneous abortion cases","volume":"10","author":"Sasaki","year":"2004","journal-title":"Mol Hum Reprod"},{"key":"10.1016\/j.fertnstert.2008.04.068_bib13","first-page":"816","article-title":"Study on the relationship between regulatory T cells and unexplained recurrent spontaneous abortion","volume":"39","author":"Qiu","year":"2004","journal-title":"Zhonghua Fu Chan Ke Za Zhi"},{"key":"10.1016\/j.fertnstert.2008.04.068_bib14","series-title":"Laboratory manual for the examination of human semen and sperm\u2013cervical mucus interaction","author":"World Health Organization","year":"1999"},{"key":"10.1016\/j.fertnstert.2008.04.068_bib15","first-page":"351","article-title":"Immunotherapy of primary habitual abortion","volume":"31","author":"Lin","year":"1996","journal-title":"Zhonghua Fu Chan Ke Za Zhi"},{"key":"10.1016\/j.fertnstert.2008.04.068_bib16","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/j.fertnstert.2007.03.037","article-title":"Proportional change of CD4(+)CD25(+) regulatory T cells in decidua and peripheral blood in unexplained recurrent spontaneous abortion patients","volume":"89","author":"Yang","year":"2008","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2008.04.068_bib17","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD000112.pub2","article-title":"Immunotherapy for recurrent miscarriage","volume":"19","author":"Porter","year":"2006","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.fertnstert.2008.04.068_bib18","doi-asserted-by":"crossref","first-page":"2280","DOI":"10.1093\/oxfordjournals.humrep.a136285","article-title":"Outcome of pregnancy in women with recurrent spontaneous abortion following immunotherapy with allogeneic lymphocytes","volume":"10","author":"Agrawal","year":"1995","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2008.04.068_bib19","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.intimp.2004.01.001","article-title":"Induction of MLR-Bf and protection of fetal loss: a current double blind randomized trial of paternal lymphocyte immunization for women with recurrent spontaneous abortion","volume":"4","author":"Pandey","year":"2004","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.fertnstert.2008.04.068_bib20","first-page":"757","article-title":"[The selection of immunogens in the active immunotherapy of URSA]","volume":"23","author":"Xu","year":"2007","journal-title":"Chin J Pract Gynecol Obstet"},{"key":"10.1016\/j.fertnstert.2008.04.068_bib21","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1159\/000292630","article-title":"Differential suppression activity induced by paternal leukocyte immunization in habitual abortion","volume":"36","author":"Behar","year":"1993","journal-title":"Gynecol Obstet Invest"},{"key":"10.1016\/j.fertnstert.2008.04.068_bib22","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1002\/lt.21061","article-title":"Vaccination against hepatitis B in liver transplant recipients: pilot analysis of cellular immune response shows evidence of HBsAg-specific regulatory T cells","volume":"13","author":"Bauer","year":"2007","journal-title":"Liver Transpl"},{"key":"10.1016\/j.fertnstert.2008.04.068_bib23","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1158\/1078-0432.CCR-07-1880","article-title":"Induction of tumor-specific CD4+ and CD8+ T-cell immunity in cervical cancer patients by a human papillomavirus type 16 E6 and E7 long peptides vaccine","volume":"14","author":"Welters","year":"2008","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.fertnstert.2008.04.068_bib24","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1002\/art.22316","article-title":"Vaccination with selected synovial T cells in rheumatoid arthritis","volume":"56","author":"Chen","year":"2007","journal-title":"Arthritis Rheum"}],"container-title":["Fertility and Sterility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028208010091?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028208010091?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T06:08:07Z","timestamp":1762150087000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0015028208010091"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,7]]},"references-count":24,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2009,7]]}},"alternative-id":["S0015028208010091"],"URL":"https:\/\/doi.org\/10.1016\/j.fertnstert.2008.04.068","relation":{},"ISSN":["0015-0282"],"issn-type":[{"value":"0015-0282","type":"print"}],"subject":[],"published":{"date-parts":[[2009,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Proportional change of CD4+CD25+ regulatory T cells after lymphocyte therapy in unexplained recurrent spontaneous abortion patients","name":"articletitle","label":"Article Title"},{"value":"Fertility and Sterility","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fertnstert.2008.04.068","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}