{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T22:43:44Z","timestamp":1792190624241,"version":"4.4.0"},"reference-count":50,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2009,7,1]],"date-time":"2009-07-01T00:00:00Z","timestamp":1246406400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,7,1]],"date-time":"2009-07-01T00:00:00Z","timestamp":1246406400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,9,12]],"date-time":"2022-09-12T00:00:00Z","timestamp":1662940800000},"content-version":"vor","delay-in-days":4821,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","fertstert.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fertility and Sterility"],"published-print":{"date-parts":[[2009,7]]},"DOI":"10.1016\/j.fertnstert.2008.05.071","type":"journal-article","created":{"date-parts":[[2008,8,10]],"date-time":"2008-08-10T04:09:50Z","timestamp":1218341390000},"page":"88-95","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":68,"title":["A case-control study identifying chromosomal polymorphic variations as forms of epigenetic alterations associated with the infertility phenotype"],"prefix":"10.1016","volume":"92","author":[{"given":"Sheroy","family":"Minocherhomji","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arundhati S.","family":"Athalye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prochi F.","family":"Madon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhananjay","family":"Kulkarni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shonali A.","family":"Uttamchandani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Firuza R.","family":"Parikh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fertnstert.2008.05.071_bib1","series-title":"Chromosomal variation in man: a catalogue of chromosomal variants and anomalies","author":"Borgaonkar","year":"1997"},{"key":"10.1016\/j.fertnstert.2008.05.071_bib2","series-title":"ISCN: an international system for human cytogenetic nomenclature","first-page":"53","year":"2005"},{"key":"10.1016\/j.fertnstert.2008.05.071_bib3","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1080\/09723757.2005.11885918","article-title":"Human population cytogenetics: a review","volume":"5","author":"Bhasin","year":"2005","journal-title":"Int J Hum Genet"},{"key":"10.1016\/j.fertnstert.2008.05.071_bib4","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/S1472-6483(10)61691-4","article-title":"Polymorphic variants on chromosomes probably play a significant role in infertility","volume":"11","author":"Madon","year":"2005","journal-title":"Reprod Biomed Online"},{"key":"10.1016\/j.fertnstert.2008.05.071_bib5","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1007\/BF03343793","article-title":"Chromosomal alterations and male infertility","volume":"23","author":"Antonelli","year":"2000","journal-title":"J Endocrinol Invest"},{"key":"10.1016\/j.fertnstert.2008.05.071_bib6","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1136\/jmg.16.5.358","article-title":"Heterochromatic polymorphism in spontaneous abortions","volume":"16","author":"Hemming","year":"1979","journal-title":"J Med Genet"},{"key":"10.1016\/j.fertnstert.2008.05.071_bib7","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1093\/humrep\/12.5.930","article-title":"Chromosomal findings in 150 couples referred for genetic counselling prior to intracytoplasmic sperm injection","volume":"112","author":"Mau","year":"1997","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2008.05.071_bib8","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1034\/j.1600-0412.2003.820109.x","article-title":"Cytogenetic studies in patients with reproductive failure","volume":"82","author":"Duzcan","year":"2003","journal-title":"Acta Obstet Gynecol Scand"},{"key":"10.1016\/j.fertnstert.2008.05.071_bib9","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1093\/humrep\/13.3.576","article-title":"Chromosome abnormalities in 447 couples undergoing intracytoplasmic sperm injection\u2014prevalence, types, sex distribution and reproductive relevance","volume":"13","author":"Meschede","year":"1998","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2008.05.071_bib10","first-page":"34","article-title":"Chromosomal studies in infertile men with oligospermia & non-obstructive azoospermia","volume":"112","author":"Nagvenkar","year":"2005","journal-title":"Indian J Med Res"},{"key":"10.1016\/j.fertnstert.2008.05.071_bib11","doi-asserted-by":"crossref","first-page":"94","DOI":"10.4103\/0971-6866.16809","article-title":"Cytogenetic causes for recurrent spontaneous abortions\u2014an experience of 742 couples (1484 cases)","volume":"11","author":"Dubey","year":"2005","journal-title":"Indian J Hum Genet"},{"key":"10.1016\/j.fertnstert.2008.05.071_bib12","first-page":"181","article-title":"Cytogenetic basis of recurrent abortions","volume":"1","author":"Thomas","year":"1999","journal-title":"Perinatology"},{"key":"10.1016\/j.fertnstert.2008.05.071_bib13","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1111\/j.1399-0004.1978.tb04140.x","article-title":"Large Y chromosome (Yq+) and increased risk of abortion","volume":"13","author":"Nielsen","year":"1978","journal-title":"Clin Genet"},{"key":"10.1016\/j.fertnstert.2008.05.071_bib14","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1086\/319506","article-title":"Olfactory receptor\u2013gene clusters, genomic-inversion polymorphisms and common chromosome rearrangements","volume":"68","author":"Giglio","year":"2001","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.fertnstert.2008.05.071_bib15","doi-asserted-by":"crossref","first-page":"59","DOI":"10.4103\/0971-6866.16803","article-title":"Chromosomal variants and genetic diseases","volume":"11","author":"Rao","year":"2005","journal-title":"Indian J Hum Genet"},{"key":"10.1016\/j.fertnstert.2008.05.071_bib16","first-page":"948","article-title":"Minor chromosomal variants and major chromosomal anomalies in couples with recurrent abortion","volume":"34","author":"Blumberg","year":"1982","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.fertnstert.2008.05.071_bib17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s004120050346","article-title":"Heterochromatin","volume":"108","author":"Hennig","year":"1999","journal-title":"Chromosoma"},{"key":"10.1016\/j.fertnstert.2008.05.071_bib18","first-page":"185","article-title":"Cytogenetic study in infertile men","volume":"46","author":"Lissitsina","year":"2003","journal-title":"Ann Genet"},{"key":"10.1016\/j.fertnstert.2008.05.071_bib19","unstructured":"Mattei MG, Luciani J. Heterochromatin, from chromosome to protein. Atlas Genet Cytogenet Oncol Haematol. January 2003. Available at: http:\/\/AtlasGeneticsOncology.org\/Educ\/HeterochromEng.html"},{"key":"10.1016\/j.fertnstert.2008.05.071_bib20","first-page":"25","article-title":"Gene environment interactions and the epigenetic basis of human diseases","volume":"10","author":"Liu","year":"2008","journal-title":"Curr Issues Mol Biol"},{"key":"10.1016\/j.fertnstert.2008.05.071_bib21","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1038\/381571a0","article-title":"Molecular chaperones in cellular protein folding","volume":"381","author":"Hartl","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.fertnstert.2008.05.071_bib22","doi-asserted-by":"crossref","first-page":"3788","DOI":"10.1101\/gad.12.24.3788","article-title":"Regulation of the heat shock transcriptional response: cross talk between a family of heat shock factors, molecular chaperones, and negative regulators","volume":"12","author":"Morimoto","year":"1998","journal-title":"Genes Dev"},{"key":"10.1016\/j.fertnstert.2008.05.071_bib23","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1091\/mbc.e03-07-0487","article-title":"Transcriptional activation of a constitutive heterochromatic domain of the human genome in response to heat shock","volume":"15","author":"Rizzi","year":"2004","journal-title":"Mol Biol Cell"},{"key":"10.1016\/j.fertnstert.2008.05.071_bib24","first-page":"271","article-title":"Heat shock factor function and regulation in response to cellular stress, growth, and differentiation signals","volume":"7","author":"Morano","year":"1999","journal-title":"Gene Exp"},{"key":"10.1016\/j.fertnstert.2008.05.071_bib25","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1083\/jcb.200109018","article-title":"In vivo binding of active heat shock transcription factor 1 to human chromosome 9 heterochromatin during stress","volume":"156","author":"Jolly","year":"2002","journal-title":"J Cell Biol"},{"key":"10.1016\/j.fertnstert.2008.05.071_bib26","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1080\/10618600.1996.10474713","article-title":"A language for data analysis and graphics","volume":"5","author":"Ihaka","year":"1996","journal-title":"J Comput Graph Stat"},{"key":"10.1016\/j.fertnstert.2008.05.071_bib27","doi-asserted-by":"crossref","first-page":"2215","DOI":"10.1093\/hmg\/10.20.2215","article-title":"Lessons from the human genome: transitions between euchromatin and heterochromatin","volume":"10","author":"Horvath","year":"2001","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.fertnstert.2008.05.071_bib28","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/nature02465","article-title":"DNA sequence and analysis of human chromosome 9","volume":"429","author":"Humphray","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.fertnstert.2008.05.071_bib29","first-page":"81","article-title":"Structural variation in chromosome No 9","volume":"17","author":"Madan","year":"1974","journal-title":"Ann Genet"},{"key":"10.1016\/j.fertnstert.2008.05.071_bib30","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1620\/tjem.166.417","article-title":"Pericentric inversion of chromosome 9 in prenatal diagnosis and infertility","volume":"166","author":"Uehara","year":"1992","journal-title":"Tohoku J Exp Med"},{"key":"10.1016\/j.fertnstert.2008.05.071_bib31","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0920-9964(99)00035-3","article-title":"Cytogenetic findings in 250 schizophrenics: evidence confirming an excess of the X chromosome aneuploidies and pericentric inversion of chromosome 9","volume":"40","author":"Osman","year":"1999","journal-title":"Schizophr Res"},{"key":"10.1016\/j.fertnstert.2008.05.071_bib32","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1046\/j.1365-2605.2003.00402.x","article-title":"The Y chromosome and male fertility and infertility","volume":"26","author":"Krausz","year":"2003","journal-title":"Int J Androl"},{"key":"10.1016\/j.fertnstert.2008.05.071_bib33","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1093\/molehr\/gah153","article-title":"A deletion of a novel heat shock gene on the Y chromosome associated with azoospermia","volume":"11","author":"Vinci","year":"2005","journal-title":"Mol Hum Reprod"},{"key":"10.1016\/j.fertnstert.2008.05.071_bib34","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0015-0282(16)45623-2","article-title":"Chromosomal variants and male fertility","volume":"36","author":"Hamer","year":"1981","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2008.05.071_bib35","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1111\/j.1442-2042.2005.01185.x","article-title":"Is there a possible correlation between chromosomal variants and spermatogenesis?","volume":"12","author":"Kayhan","year":"2005","journal-title":"Int J Urol"},{"key":"10.1016\/j.fertnstert.2008.05.071_bib36","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/S0015-0282(99)00158-2","article-title":"Incidence of sperm aneuploidy in relation to semen characteristics and assisted reproductive outcome","volume":"72","author":"Colombero","year":"1999","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2008.05.071_bib37","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1038\/35057170","article-title":"A physical map of the human Y chromosome","volume":"409","author":"Tilford","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.fertnstert.2008.05.071_bib38","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1038\/nature01722","article-title":"The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes","volume":"423","author":"Skaletsky","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.fertnstert.2008.05.071_bib39","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1111\/j.1439-0272.1987.tb01929.x","article-title":"High incidence of minor chromosomal variants in teratozoospermic males","volume":"19","author":"Eiben","year":"1987","journal-title":"Andrologia"},{"key":"10.1016\/j.fertnstert.2008.05.071_bib40","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1046\/j.1442-2042.2001.00242.x","article-title":"Chromosomal variants among 1790 infertile men","volume":"8","author":"Nakamura","year":"2001","journal-title":"Int J Urol"},{"key":"10.1016\/j.fertnstert.2008.05.071_bib41","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/s004120050309","article-title":"Characterization of sequences associated with position effect variegation at pericentric sites in Drosophila heterochromatin","volume":"107","author":"Cryderman","year":"1998","journal-title":"Chromosoma"},{"key":"10.1016\/j.fertnstert.2008.05.071_bib42","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1101\/gad.873601","article-title":"Conversion of a gene-specific repressor to a regional silencer","volume":"15","author":"Laura","year":"2001","journal-title":"Genes Dev"},{"key":"10.1016\/j.fertnstert.2008.05.071_bib43","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1097\/00004583-199911000-00022","article-title":"Genetics of childhood disorders VIII. Making sense out of nonsense","volume":"38","author":"Greally","year":"1999","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"key":"10.1016\/j.fertnstert.2008.05.071_bib44","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1038\/248334a0","article-title":"Activity of DNA templates during cell division and cell differentiation","volume":"248","author":"Nakatsu","year":"1974","journal-title":"Nature"},{"key":"10.1016\/j.fertnstert.2008.05.071_bib45","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1056\/NEJM197306072882310","article-title":"Gene de-repression","volume":"288","author":"Frenster","year":"1973","journal-title":"New Engl J Med"},{"key":"10.1016\/j.fertnstert.2008.05.071_bib46","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.molcel.2006.01.028","article-title":"A transient heterochromatic state in Xist preempts X inactivation choice without RNA stabilization","volume":"21","author":"Sun","year":"2006","journal-title":"Mol Cell"},{"key":"10.1016\/j.fertnstert.2008.05.071_bib47","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1038\/190372a0","article-title":"Gene action in the X-chromosome of the mouse (Mus musculus L.)","volume":"190","author":"Lyon","year":"1961","journal-title":"Nature"},{"key":"10.1016\/j.fertnstert.2008.05.071_bib48","series-title":"Chromosome abnormalities and genetic counseling","author":"Gardner","year":"2003"},{"key":"10.1016\/j.fertnstert.2008.05.071_bib49","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1111\/j.1399-0004.1982.tb00764.x","article-title":"The effect of variant chromosomes on reproductive fitness in man","volume":"21","author":"Carothers","year":"1982","journal-title":"Clin Genet"},{"key":"10.1016\/j.fertnstert.2008.05.071_bib50","first-page":"97","article-title":"Heterochromatic chromosome variation and reproductive failure","volume":"2","author":"Bobrow","year":"1985","journal-title":"Exp Clin Immunogenet"}],"container-title":["Fertility and Sterility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028208011862?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028208011862?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T06:08:31Z","timestamp":1762150111000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0015028208011862"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,7]]},"references-count":50,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2009,7]]}},"alternative-id":["S0015028208011862"],"URL":"https:\/\/doi.org\/10.1016\/j.fertnstert.2008.05.071","relation":{},"ISSN":["0015-0282"],"issn-type":[{"value":"0015-0282","type":"print"}],"subject":[],"published":{"date-parts":[[2009,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A case-control study identifying chromosomal polymorphic variations as forms of epigenetic alterations associated with the infertility phenotype","name":"articletitle","label":"Article Title"},{"value":"Fertility and Sterility","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fertnstert.2008.05.071","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}