{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T14:33:13Z","timestamp":1793370793166,"version":"4.5.0"},"reference-count":47,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2009,8,1]],"date-time":"2009-08-01T00:00:00Z","timestamp":1249084800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,8,1]],"date-time":"2009-08-01T00:00:00Z","timestamp":1249084800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,5,27]],"date-time":"2022-05-27T00:00:00Z","timestamp":1653609600000},"content-version":"vor","delay-in-days":4682,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","fertstert.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fertility and Sterility"],"published-print":{"date-parts":[[2009,8]]},"DOI":"10.1016\/j.fertnstert.2008.06.004","type":"journal-article","created":{"date-parts":[[2008,8,16]],"date-time":"2008-08-16T05:13:33Z","timestamp":1218863613000},"page":"626-634","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":70,"title":["Adolescent girls with polycystic ovary syndrome showing different phenotypes have a different metabolic profile associated with increasing androgen levels"],"prefix":"10.1016","volume":"92","author":[{"given":"Franca","family":"Fruzzetti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daria","family":"Perini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronica","family":"Lazzarini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donatella","family":"Parrini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea R.","family":"Genazzani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fertnstert.2008.06.004_bib1","doi-asserted-by":"crossref","first-page":"4006","DOI":"10.1210\/jcem.84.11.6148","article-title":"A survey of the polycystic ovary syndrome in the Greek island of Lesbos: hormonal and metabolic profile","volume":"84","author":"Diamanti-Kandarakis","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2008.06.004_bib2","series-title":"Polycystic ovary syndrome","first-page":"377","article-title":"Diagnostic criteria for polycystic ovary syndrome; towards a rational approach","author":"Zawadski","year":"1992"},{"key":"10.1016\/j.fertnstert.2008.06.004_bib3","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.fertnstert.2003.10.004","article-title":"Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome","volume":"81","year":"2004","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2008.06.004_bib4","first-page":"47","article-title":"Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS)","volume":"19","year":"2004","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2008.06.004_bib5","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1093\/humupd\/dmg044","article-title":"Ultrasound assessment of the polycystic ovary: international consensus definitions","volume":"9","author":"Balen","year":"2003","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.fertnstert.2008.06.004_bib6","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1111\/j.1471-0528.2006.01008.x","article-title":"PCOS according to the Rotterdam consensus criteria: change in prevalence among WHO-II anovulation and association with metabolic factors","volume":"113","author":"Broekmans","year":"2006","journal-title":"BJOG"},{"key":"10.1016\/j.fertnstert.2008.06.004_bib7","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1111\/j.1365-2265.2007.02954.x","article-title":"Unravelling the phenotypic map of polycystic ovaries syndrome (PCOS): a prospective study of 634 women with PCOS","volume":"67","author":"Diamanti-Kandarakis","year":"2007","journal-title":"Clin Endocrinol (Oxf)"},{"key":"10.1016\/j.fertnstert.2008.06.004_bib8","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.2337\/diab.38.9.1165","article-title":"Profound peripheral insulin resistance, independent of obesity, in polycystic ovary syndrome","volume":"38","author":"Dunaif","year":"1989","journal-title":"Diabetes"},{"key":"10.1016\/j.fertnstert.2008.06.004_bib9","first-page":"774","article-title":"Insulin resistance and the polycystic ovary syndrome: mechanisms and implication for pathogenesis","volume":"18","author":"Dunaif","year":"1997","journal-title":"Endocr Rev"},{"key":"10.1016\/j.fertnstert.2008.06.004_bib10","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1210\/jcem-61-5-946","article-title":"Lipoprotein lipid concentrations and cardiovascular risk in women with polycystic ovary syndrome","volume":"61","author":"Wild","year":"1985","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2008.06.004_bib11","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/S0002-9343(01)00948-2","article-title":"Prevalence and predictors of dyslipidemia in women with polycystic ovary syndrome","volume":"111","author":"Legro","year":"2001","journal-title":"Am J Med"},{"key":"10.1016\/j.fertnstert.2008.06.004_bib12","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.tem.2007.07.004","article-title":"Pathophysiology and types of dyslipidemia in PCOS","volume":"18","author":"Diamanti-Kandarakis","year":"2007","journal-title":"Trends Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2008.06.004_bib13","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1210\/jc.2006-1705","article-title":"Atherogenic lipoprotein phenotype and low density lipoproteins size and subclasses in women with polycystic ovary syndrome","volume":"92","author":"Berneis","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2008.06.004_bib14","doi-asserted-by":"crossref","first-page":"3694","DOI":"10.1210\/jc.2004-1136","article-title":"Cardiovascular risk in PCOS","volume":"89","author":"Guzick","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2008.06.004_bib15","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.atherosclerosis.2005.10.007","article-title":"Cardiovascular disease in the polycystic ovary syndrome: new insights and perspectives","volume":"185","author":"Cussons","year":"2006","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.fertnstert.2008.06.004_bib16","author":"Shaw","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2008.06.004_bib17","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1111\/j.1365-2265.1985.tb00165.x","article-title":"Premenarcheal endocrine changes in relation to age at menarche","volume":"22","author":"Apter","year":"1985","journal-title":"Clin Endocrinol (Oxf)"},{"key":"10.1016\/j.fertnstert.2008.06.004_bib18","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/S0015-0282(16)59294-2","article-title":"Postmenarchal evolution of endocrine pattern and ovarian aspects in adolescents with menstrual irregularities","volume":"48","author":"Venturoli","year":"1987","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2008.06.004_bib19","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1203\/01.pdr.0000246097.73031.27","article-title":"Longitudinal study of physiologic insulin resistance and metabolic changes of puberty","volume":"60","author":"Hannon","year":"2006","journal-title":"Pediatr Res"},{"key":"10.1016\/j.fertnstert.2008.06.004_bib20","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1016\/S0022-3476(89)80438-X","article-title":"Increased insulin secretion in puberty: a compensatory response to reductions in insulin sensitivity","volume":"114","author":"Caprio","year":"1989","journal-title":"J Pediatr"},{"key":"10.1016\/j.fertnstert.2008.06.004_bib21","first-page":"45","article-title":"The LMS method for constructing normalized growth standards","volume":"44","author":"Cole","year":"1990","journal-title":"Eur J Clin Nutr"},{"key":"10.1016\/j.fertnstert.2008.06.004_bib22","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.2337\/diacare.22.9.1462","article-title":"Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp","volume":"22","author":"Matsuda","year":"1999","journal-title":"Diabetes Care"},{"key":"10.1016\/j.fertnstert.2008.06.004_bib23","doi-asserted-by":"crossref","first-page":"944","DOI":"10.2337\/diab.26.10.944","article-title":"Insulin responses in equivocal and definite diabetes, with special reference to subjects who had mild glucose intolerance but later developed definite diabetes","volume":"26","author":"Kosaka","year":"1977","journal-title":"Diabetes"},{"key":"10.1016\/j.fertnstert.2008.06.004_bib24","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1093\/clinchem\/18.6.499","article-title":"Estimation of the concentrations of low density lipoprotein cholesterol without use of preparative ultracentrifuge","volume":"18","author":"Friedewald","year":"1972","journal-title":"Clin Chem"},{"key":"10.1016\/j.fertnstert.2008.06.004_bib25","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1196\/annals.1365.014","article-title":"Polycystic ovary syndrome: a multifaceted disease from adolescence to adult age","volume":"1092","author":"Pasquali","year":"2006","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.fertnstert.2008.06.004_bib26","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1097\/GRF.0b013e31802f50fc","article-title":"Polycystic ovary syndrome: early detection in the adolescent","volume":"50","author":"Jeffrey Chang","year":"2007","journal-title":"Clin Obstet Gynecol"},{"key":"10.1016\/j.fertnstert.2008.06.004_bib27","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1210\/jc.2006-2012","article-title":"Clinical review: identifying children at risk for polycystic ovary syndrome","volume":"92","author":"Rosenfield","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2008.06.004_bib28","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/S0015-0282(16)56160-3","article-title":"Standards for ovarian volume in childhood and puberty","volume":"60","author":"Bridges","year":"1993","journal-title":"Fertil Steril"},{"issue":"Suppl 1","key":"10.1016\/j.fertnstert.2008.06.004_bib29","doi-asserted-by":"crossref","first-page":"S6","DOI":"10.1016\/j.fertnstert.2006.04.015","article-title":"Clinical expression of polycystic ovary syndrome in adolescent girls","volume":"86","author":"Sultan","year":"2006","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2008.06.004_bib30","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/j.metabol.2005.11.003","article-title":"Obesity, free testosterone, and cardiovascular risk factors in adolescents with polycystic ovary syndrome and regularly cycling adolescents","volume":"55","author":"Glueck","year":"2006","journal-title":"Metabolism"},{"key":"10.1016\/j.fertnstert.2008.06.004_bib31","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1111\/j.1365-2265.2007.02849.x","article-title":"Serum leptin, oxidized low density lipoprotein and plasma asymmetric dimethylarginine levels and their relationship with dyslipidaemia in adolescent girls with polycystic ovary syndrome","volume":"67","author":"Demirel","year":"2007","journal-title":"Clin Endocrinol (Oxf)"},{"key":"10.1016\/j.fertnstert.2008.06.004_bib32","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1210\/jc.2005-1666","article-title":"Adolescent girls with polycystic ovary syndrome have an increased risk of metabolic syndrome associated with increasing androgen levels independent of obesity and insulin resistance","volume":"91","author":"Coviello","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2008.06.004_bib33","first-page":"73","article-title":"Effect of body composition on indices of insulin sensitivity and beta-cell function in healthy men","volume":"36","author":"Cervenakova","year":"2002","journal-title":"Endocr Regul"},{"key":"10.1016\/j.fertnstert.2008.06.004_bib34","first-page":"1052","article-title":"Enhanced early insulin response to glucose in relation to insulin resistance in women with polycystic ovary syndrome and normal glucose tolerance","volume":"78","author":"Holte","year":"1994","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2008.06.004_bib35","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.2337\/diacare.25.7.1217","article-title":"Insulin sensitivity and beta-cell function in women with polycystic ovary syndrome","volume":"25","author":"Vrb\u00edkov\u00e1","year":"2002","journal-title":"Diabetes Care"},{"issue":"Suppl 1","key":"10.1016\/j.fertnstert.2008.06.004_bib36","first-page":"487","article-title":"Insulin resistance in childhood obesity","volume":"15","author":"Caprio","year":"2002","journal-title":"J Pediatr Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2008.06.004_bib37","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1097\/00019501-199809080-00003","article-title":"Abdominal obesity and cardiovascular risk in children","volume":"9","author":"Goran","year":"1998","journal-title":"Coron Artery Dis"},{"key":"10.1016\/j.fertnstert.2008.06.004_bib38","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1093\/humupd\/dmi054","article-title":"Low-dose flutamide-metformin therapy for hyperinsulinemic hyperandrogenism in non-obese adolescents and women","volume":"12","author":"Ib\u00e1\u00f1ez","year":"2006","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.fertnstert.2008.06.004_bib39","doi-asserted-by":"crossref","first-page":"2289","DOI":"10.1093\/humrep\/deg440","article-title":"Differences in body weight between American and Italian women with polycystic ovary syndrome: influence of the diet","volume":"11","author":"Carmina","year":"2003","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2008.06.004_bib40","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1016\/S0015-0282(03)00347-9","article-title":"The androgen sex hormone profile is an essential feature of metabolic syndrome in premenopausal women: a controlled community-based study","volume":"79","author":"Korhonen","year":"2003","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2008.06.004_bib41","doi-asserted-by":"crossref","first-page":"2699","DOI":"10.1210\/jcem.83.8.5041","article-title":"The effect of a pure antiandrogen receptor blocker, flutamide, on the lipid profile in the polycystic ovary syndrome","volume":"83","author":"Diamanti-Kandarakis","year":"1998","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2008.06.004_bib42","first-page":"210","article-title":"Early onset adiposity: a pathway to polycystic ovary syndrome in adolescents?","volume":"6","author":"Diamanti-Kandarakis","year":"2007","journal-title":"Hormones"},{"key":"10.1016\/j.fertnstert.2008.06.004_bib43","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1111\/j.1365-2265.2007.02764.x","article-title":"Metabolic characteristics of women with polycystic ovaries and oligo-amenorrhoea but normal androgen levels: implications for the management of polycystic ovary syndrome","volume":"66","author":"Barber","year":"2007","journal-title":"Clin Endocrinol (Oxf)"},{"key":"10.1016\/j.fertnstert.2008.06.004_bib44","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1016\/j.fertnstert.2007.01.032","article-title":"Risk of metabolic complications in the new PCOS phenotypes based on the Rotterdam criteria","volume":"88","author":"Shroff","year":"2007","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2008.06.004_bib45","doi-asserted-by":"crossref","first-page":"4842","DOI":"10.1210\/jc.2006-1327","article-title":"Characterizing discrete subsets of polycystic ovary syndrome as defined by the Rotterdam criteria: the impact of weight on phenotype and metabolic features","volume":"91","author":"Welt","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2008.06.004_bib46","doi-asserted-by":"crossref","first-page":"2740","DOI":"10.1210\/jc.2004-2363","article-title":"Association of hyperandrogenemic and metabolic phenotype with carotid intima-media thickness in young women with polycystic ovary syndrome","volume":"90","author":"Vryonidou","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2008.06.004_bib47","doi-asserted-by":"crossref","first-page":"2545","DOI":"10.1210\/jc.2004-2279","article-title":"Phenotypic variations in hyperandrogenic women influences the findings of abnormal metabolic and cardiovascular risk parameters","volume":"90","author":"Carmina","year":"2005","journal-title":"J Clin Endocrinol Metab"}],"container-title":["Fertility and Sterility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028208013009?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028208013009?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T21:06:35Z","timestamp":1762895195000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0015028208013009"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,8]]},"references-count":47,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2009,8]]}},"alternative-id":["S0015028208013009"],"URL":"https:\/\/doi.org\/10.1016\/j.fertnstert.2008.06.004","relation":{},"ISSN":["0015-0282"],"issn-type":[{"value":"0015-0282","type":"print"}],"subject":[],"published":{"date-parts":[[2009,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Adolescent girls with polycystic ovary syndrome showing different phenotypes have a different metabolic profile associated with increasing androgen levels","name":"articletitle","label":"Article Title"},{"value":"Fertility and Sterility","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fertnstert.2008.06.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}