{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T14:18:40Z","timestamp":1777299520905,"version":"3.51.4"},"reference-count":11,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2009,3,1]],"date-time":"2009-03-01T00:00:00Z","timestamp":1235865600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,3,1]],"date-time":"2009-03-01T00:00:00Z","timestamp":1235865600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,5,27]],"date-time":"2022-05-27T00:00:00Z","timestamp":1653609600000},"content-version":"vor","delay-in-days":4835,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","fertstert.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fertility and Sterility"],"published-print":{"date-parts":[[2009,3]]},"DOI":"10.1016\/j.fertnstert.2008.10.003","type":"journal-article","created":{"date-parts":[[2009,1,11]],"date-time":"2009-01-11T04:47:37Z","timestamp":1231649257000},"page":"929.e13-929.e15","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["A case of a methotrexate-resistant ectopic pregnancy in which dactinomycin was effective as a second-line chemotherapy"],"prefix":"10.1016","volume":"91","author":[{"given":"Satoe","family":"Fujioka","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiki","family":"Yamashita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sachiko","family":"Kawabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideki","family":"Kamegai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshito","family":"Terai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahide","family":"Ohmichi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.fertnstert.2008.10.003_bib1","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/S0002-9378(16)37018-1","article-title":"Combined intra- and extrauterine pregnancy","volume":"74","author":"Winter","year":"1957","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.fertnstert.2008.10.003_bib2","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1016\/j.fertnstert.2007.01.064","article-title":"Does methotrexate treatment for ectopic pregnancy influence the patient's performance during a subsequent in vitro fertilization\/embryo transfer cycle?","volume":"88","author":"Orvieto","year":"2007","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2008.10.003_bib3","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/S0015-0282(97)80064-7","article-title":"Current status of surgical and non-surgical treatment of ectopic pregnancy","volume":"67","author":"Yao","year":"1997","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2008.10.003_bib4","doi-asserted-by":"crossref","first-page":"591","DOI":"10.7863\/jum.2005.24.5.591","article-title":"Presence of yolk sac on transvaginal sonography is the most reliable predictor of single dose methotrexate treatment failure in ectopic pregnancy","volume":"24","author":"Bixby","year":"2005","journal-title":"J Ultrasound Med"},{"key":"10.1016\/j.fertnstert.2008.10.003_bib5","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1056\/NEJM200011023431807","article-title":"Nonsurgical treatment of ectopic pregnancy","volume":"343","author":"Lipscomb","year":"2000","journal-title":"N Engl J Med"},{"key":"10.1016\/j.fertnstert.2008.10.003_bib6","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1067\/mob.2003.310","article-title":"Predictors of success with methotrexate treatment of tubal ectopic pregnancy at Grady Memorial Hospital","volume":"188","author":"Potter","year":"2003","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.fertnstert.2008.10.003_bib7","first-page":"192","article-title":"A randomized trial comparing single dose systemic methotrexate and laparoscopic surgery for the treatment of unruptured tubal pregnancy","volume":"108","author":"Sowter","year":"2001","journal-title":"Br J Obstet Gynecol"},{"key":"10.1016\/j.fertnstert.2008.10.003_bib8","first-page":"S54","article-title":"Methotrexate is safe for the management of interstitial ectopic pregnancy","volume":"101","author":"Rodriguez","year":"2003","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.fertnstert.2008.10.003_bib9","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0301-2115(98)00269-3","article-title":"Survival of cornual (interstitial) pregnancy","volume":"84","author":"Idama","year":"1999","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"10.1016\/j.fertnstert.2008.10.003_bib10","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S0015-0282(99)00242-3","article-title":"Conservative medical and surgical management of interstitial ectopic pregnancy","volume":"72","author":"Lau","year":"1999","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2008.10.003_bib11","first-page":"160","article-title":"Complete response of a persistent ectopic pregnancy to Dactinomycin after methotrexate failure, a case report","volume":"40","author":"Neary","year":"1995","journal-title":"J Reprod Med"}],"container-title":["Fertility and Sterility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028208041307?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028208041307?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T13:29:52Z","timestamp":1777296592000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0015028208041307"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,3]]},"references-count":11,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2009,3]]}},"alternative-id":["S0015028208041307"],"URL":"https:\/\/doi.org\/10.1016\/j.fertnstert.2008.10.003","relation":{},"ISSN":["0015-0282"],"issn-type":[{"value":"0015-0282","type":"print"}],"subject":[],"published":{"date-parts":[[2009,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A case of a methotrexate-resistant ectopic pregnancy in which dactinomycin was effective as a second-line chemotherapy","name":"articletitle","label":"Article Title"},{"value":"Fertility and Sterility","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fertnstert.2008.10.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}