{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:08:53Z","timestamp":1791216533312,"version":"4.1.0"},"reference-count":40,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2010,3,1]],"date-time":"2010-03-01T00:00:00Z","timestamp":1267401600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,3,1]],"date-time":"2010-03-01T00:00:00Z","timestamp":1267401600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,5,27]],"date-time":"2022-05-27T00:00:00Z","timestamp":1653609600000},"content-version":"vor","delay-in-days":4470,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","fertstert.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fertility and Sterility"],"published-print":{"date-parts":[[2010,3]]},"DOI":"10.1016\/j.fertnstert.2008.11.016","type":"journal-article","created":{"date-parts":[[2009,1,10]],"date-time":"2009-01-10T04:26:28Z","timestamp":1231561588000},"page":"1185-1191","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":58,"title":["Prevalence of polycystic ovary syndrome in young women who had idiopathic central precocious puberty"],"prefix":"10.1016","volume":"93","author":[{"given":"Roberto","family":"Franceschi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rossella","family":"Gaudino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alma","family":"Marcolongo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Chiara","family":"Gallo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Rossi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franco","family":"Antoniazzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciano","family":"Tat\u00f2","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fertnstert.2008.11.016_bib1","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1210\/jc.2006-2012","article-title":"Clinical review: identifying children at risk for polycystic ovary syndrome","volume":"92","author":"Rosenfield","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2008.11.016_bib2","doi-asserted-by":"crossref","first-page":"2745","DOI":"10.1210\/jc.2003-032046","article-title":"The prevalence and features of the polycystic ovary syndrome in an unselected population","volume":"89","author":"Azziz","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2008.11.016_bib3","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1210\/jc.2005-1666","article-title":"Adolescent girls with polycystic ovary syndrome have an increased risk of metabolic syndrome associated with increasing androgen levels independent of obesity and insulin resistance","volume":"91","author":"Coviello","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2008.11.016_bib4","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1001\/archpedi.156.6.556","article-title":"Quality of life in adolescents girls with polycystic ovary syndrome","volume":"156","author":"Trent","year":"2002","journal-title":"Arch Pediatr Adolesc Med"},{"key":"10.1016\/j.fertnstert.2008.11.016_bib5","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1093\/humrep\/deh098","article-title":"The Rotterdam ESHRE\/ASRM PCOS consensus workshop group. 2003 revised consensus on diagnostic criteria and long term health risks related to polycystic ovary syndrome (PCOS)","volume":"19","year":"2004","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2008.11.016_bib6","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1210\/jc.2005-2153","article-title":"Controversy in clinical endocrinology. Diagnosis of polycystic ovarian syndrome: the Rotterdam criteria are premature","volume":"91","author":"Azziz","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2008.11.016_bib7","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1210\/jc.2005-2501","article-title":"Controversy in clinical endocrinology. Diagnosis of polycystic ovarian syndrome: in defense of Rotterdam criteria","volume":"91","author":"Franks","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2008.11.016_bib8","doi-asserted-by":"crossref","first-page":"4237","DOI":"10.1210\/jc.2006-0178","article-title":"Position statement: criteria for defining polycystic ovary syndrome as a predominantly hyperandrogenic syndrome: an Androgen Excess Society guideline","volume":"91","author":"Azziz","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2008.11.016_bib9","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.jpag.2007.07.007","article-title":"Polycystic ovary syndrome in adolescents","volume":"21","author":"O'Brien","year":"2008","journal-title":"J\u00a0Pediatr Adolesc Gynecol"},{"key":"10.1016\/j.fertnstert.2008.11.016_bib10","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1055\/s-2007-984741","article-title":"Neuroendocrine effects of androgens in adult polycystic ovary syndrome and female puberty","volume":"25","author":"Blank","year":"2007","journal-title":"Semin Reprod Med"},{"key":"10.1016\/j.fertnstert.2008.11.016_bib11","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1056\/NEJMra041536","article-title":"Polycystic ovary syndrome","volume":"352","author":"Ehrmann","year":"2005","journal-title":"N Engl J Med"},{"key":"10.1016\/j.fertnstert.2008.11.016_bib12","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.gyobfe.2003.10.027","article-title":"Polycystic ovary syndrome in pubertal period: clinical, biological, metabolic and genetic polymorphism","volume":"32","author":"Trim\u00e8che","year":"2004","journal-title":"Gynecol Obstet Fertil"},{"key":"10.1016\/j.fertnstert.2008.11.016_bib13","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1210\/jc.2005-2099","article-title":"Inverse relationship between luteinizing hormone and body mass index in polycystic ovarian syndrome: investigation of hypothalamic and pituitary contributions","volume":"91","author":"Pag\u00e1n","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2008.11.016_bib14","first-page":"278","article-title":"Acceleration of luteinizing hormone pulse frequency in adolescent girls with a history of central precocious puberty with versus without hyperandrogenism","volume":"68","author":"Escobar","year":"2007","journal-title":"Horm Res"},{"key":"10.1016\/j.fertnstert.2008.11.016_bib15","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/0002-9378(84)90118-2","article-title":"Evolution of the hyperandrogenism\u2013polycystic ovary syndrome from isosexual precocious puberty: report of two cases","volume":"149","author":"Root","year":"1984","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.fertnstert.2008.11.016_bib16","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1159\/000182288","article-title":"Final height attainment and gonadal function in girls with precocious puberty treated with cyproterone acetate","volume":"37","author":"Cisternino","year":"1992","journal-title":"Horm Res"},{"key":"10.1016\/j.fertnstert.2008.11.016_bib17","first-page":"4480","article-title":"Is obesity an outcome of gonadotropin-releasing hormone agonist administration? Analysis of growth and body composition in 110 patients with central precocious puberty","volume":"84","author":"Palmert","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2008.11.016_bib18","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0022-3476(98)70493-7","article-title":"Central precocious puberty in girls: internal genitalia before, during and after treatment with long-acting gonadotropin-releasing hormone analogues","volume":"132","author":"Jensen","year":"1998","journal-title":"J Pediatr"},{"key":"10.1016\/j.fertnstert.2008.11.016_bib19","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1210\/jc.2007-1216","article-title":"Long-term observation of 87 girls with idiopathic central precocious puberty treated with GnRH analogues: impact on adult height, body mass index, bone mineral content and reproductive function","volume":"93","author":"Pasquino","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2008.11.016_bib20","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1136\/adc.45.244.755","article-title":"Standards for children's height at ages 2\u20139 allowing for height of parents","volume":"45","author":"Tanner","year":"1970","journal-title":"Arch Dis Child"},{"key":"10.1016\/j.fertnstert.2008.11.016_bib21","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/S0022-3476(52)80205-7","article-title":"Tables for predicting adult height from skeletal age: revised for use with the Greulich and Pyle hand standards","volume":"40","author":"Bayley","year":"1952","journal-title":"J Pediatr"},{"key":"10.1016\/j.fertnstert.2008.11.016_bib22","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1007\/BF03344156","article-title":"Italian cross-sectional growth charts for height, weight and BMI (2 to 20 yr)","volume":"29","author":"Cacciari","year":"2006","journal-title":"J Endocrinol Invest"},{"key":"10.1016\/j.fertnstert.2008.11.016_bib23","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1136\/adc.44.235.291","article-title":"Variations in pattern of pubertal changes in girls","volume":"44","author":"Marshall","year":"1969","journal-title":"Arch Dis Child"},{"key":"10.1016\/j.fertnstert.2008.11.016_bib24","first-page":"2248","article-title":"Determinants of abnormal gonadotropin secretion in clinically defined women with polycystic ovary syndrome","volume":"82","author":"Taylor","year":"1997","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2008.11.016_bib25","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.2337\/diacare.22.9.1462","article-title":"Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp","volume":"22","author":"Matzuda","year":"1999","journal-title":"Diabetes Care"},{"key":"10.1016\/j.fertnstert.2008.11.016_bib26","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1148\/125.2.477","article-title":"Gray-scale ultrasonography of the normal female pelvis","volume":"125","author":"Sample","year":"1977","journal-title":"Radiology"},{"key":"10.1016\/j.fertnstert.2008.11.016_bib27","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1148\/radiology.153.1.6473771","article-title":"Pelvic organs in premenarcheal girls: real-time ultrasonography","volume":"153","author":"Orsini","year":"1984","journal-title":"Radiology"},{"key":"10.1016\/j.fertnstert.2008.11.016_bib28","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1016\/S0140-6736(85)92552-8","article-title":"Multifollicular ovaries: clinical and endocrine features and response to pulsatile gonadotropin releasing hormone","volume":"2","author":"Adams","year":"1985","journal-title":"Lancet"},{"key":"10.1016\/j.fertnstert.2008.11.016_bib29","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1093\/humrep\/deg115","article-title":"Ultrasound examination of polycystic ovaries: is it worth counting the follicles?","volume":"18","author":"Jonard","year":"2003","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2008.11.016_bib30","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1136\/bmj.296.6626.878","article-title":"Polycystic ovaries in childhood","volume":"296","author":"Brook","year":"1988","journal-title":"Br Med J"},{"key":"10.1016\/j.fertnstert.2008.11.016_bib31","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1016\/S0140-6736(85)92552-8","article-title":"Multifollicular ovaries: clinical and endocrine features and response to pulsatile gonadotropin releasing hormone","volume":"2","author":"Adams","year":"1985","journal-title":"Lancet"},{"key":"10.1016\/j.fertnstert.2008.11.016_bib32","doi-asserted-by":"crossref","first-page":"3878","DOI":"10.1210\/jc.2006-1085","article-title":"Polycystic ovarian morphology in normal women does not predict the development of polycystic ovary syndrome","volume":"91","author":"Murphy","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2008.11.016_bib33","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/j.jpeds.2006.05.026","article-title":"Reproductive outcome in patients treated and not treated for idiopathic early puberty: long-term results of a randomized trial in adults","volume":"149","author":"Cassio","year":"2006","journal-title":"J Pediatr"},{"key":"10.1016\/j.fertnstert.2008.11.016_bib34","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1530\/eje.0.1330403","article-title":"Early polycystic ovary-like syndrome in girls with central precocious puberty and exaggerated adrenal response","volume":"133","author":"Lazar","year":"1995","journal-title":"Eur J Endocrinol"},{"key":"10.1016\/j.fertnstert.2008.11.016_bib35","doi-asserted-by":"crossref","first-page":"4208","DOI":"10.1210\/jc.2007-0870","article-title":"17-hydroxyprogesterone responses to gonadotropin-releasing hormone disclose distinct phenotypes of functional ovarian hyperandrogenism and polycystic ovary syndrome","volume":"92","author":"Pasquali","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2008.11.016_bib36","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1093\/humrep\/del395","article-title":"Polycystic ovaries after precocious pubarche: relation to prenatal growth","volume":"22","author":"Ib\u00e1\u00f1ez","year":"2007","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2008.11.016_bib37","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1056\/NEJMct0707092","article-title":"Metformin for the treatment of the polycystic ovary syndrome","volume":"358","author":"Nestler","year":"2008","journal-title":"N Engl J Med"},{"key":"10.1016\/j.fertnstert.2008.11.016_bib38","doi-asserted-by":"crossref","first-page":"3786","DOI":"10.1210\/jc.2006-0835","article-title":"Functional significance of polycystic-size ovaries in healthy adolescents","volume":"91","author":"Mortensen","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2008.11.016_bib39","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/S0015-0282(16)56160-3","article-title":"Standards for ovarian volume in childhood and puberty","volume":"60","author":"Bridges","year":"1993","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2008.11.016_bib40","doi-asserted-by":"crossref","first-page":"4343","DOI":"10.1210\/jc.2003-031600","article-title":"Polycystic ovarian morphology with regular ovulatory cycles: insights into the pathophysiology of polycystic ovarian syndrome","volume":"89","author":"Adams","year":"2004","journal-title":"J Clin Endocrinol Metab"}],"container-title":["Fertility and Sterility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028208045780?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028208045780?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T07:42:00Z","timestamp":1758008520000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0015028208045780"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,3]]},"references-count":40,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2010,3]]}},"alternative-id":["S0015028208045780"],"URL":"https:\/\/doi.org\/10.1016\/j.fertnstert.2008.11.016","relation":{},"ISSN":["0015-0282"],"issn-type":[{"value":"0015-0282","type":"print"}],"subject":[],"published":{"date-parts":[[2010,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prevalence of polycystic ovary syndrome in young women who had idiopathic central precocious puberty","name":"articletitle","label":"Article Title"},{"value":"Fertility and Sterility","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fertnstert.2008.11.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}