{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:12:43Z","timestamp":1787238763250,"version":"build-2736575974"},"reference-count":33,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2010,4,1]],"date-time":"2010-04-01T00:00:00Z","timestamp":1270080000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,4,1]],"date-time":"2010-04-01T00:00:00Z","timestamp":1270080000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,5,27]],"date-time":"2022-05-27T00:00:00Z","timestamp":1653609600000},"content-version":"vor","delay-in-days":4439,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","fertstert.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fertility and Sterility"],"published-print":{"date-parts":[[2010,4]]},"DOI":"10.1016\/j.fertnstert.2008.12.052","type":"journal-article","created":{"date-parts":[[2009,2,7]],"date-time":"2009-02-07T05:45:01Z","timestamp":1233985501000},"page":"1805-1808","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":69,"title":["Fertility in women with BRCA mutations: a case-control study"],"prefix":"10.1016","volume":"93","author":[{"given":"Tuya","family":"Pal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Keefe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven A.","family":"Narod","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fertnstert.2008.12.052_bib1","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1086\/301749","article-title":"Genetic heterogeneity and penetrance analysis of the BRCA1 and BRCA2 genes in breast cancer families. The Breast Cancer Linkage Consortium","volume":"62","author":"Ford","year":"1998","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.fertnstert.2008.12.052_bib2","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/S1097-2765(00)80276-2","article-title":"Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells","volume":"2","author":"Chen","year":"1998","journal-title":"Mol Cell"},{"key":"10.1016\/j.fertnstert.2008.12.052_bib3","doi-asserted-by":"crossref","first-page":"7061","DOI":"10.1128\/MCB.19.10.7061","article-title":"Growth retardation, DNA repair defects, and lack of spermatogenesis in BRCA1-deficient mice","volume":"19","author":"Cressman","year":"1999","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.fertnstert.2008.12.052_bib4","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/S0092-8674(02)01052-8","article-title":"BRCA1 supports XIST RNA concentration on the inactive X chromosome","volume":"111","author":"Ganesan","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.fertnstert.2008.12.052_bib5","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.cell.2006.08.053","article-title":"The BRCA1\/BARD1 heterodimer modulates ran-dependent mitotic spindle assembly","volume":"127","author":"Joukov","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.fertnstert.2008.12.052_bib6","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0047-6374(00)00151-2","article-title":"Repair of telomeric DNA prior to replicative senescence","volume":"118","author":"Lansdorp","year":"2000","journal-title":"Mech Ageing Dev"},{"key":"10.1016\/j.fertnstert.2008.12.052_bib7","first-page":"5548","article-title":"BRCA1 and BRCA2 are necessary for the transcription-coupled repair of the oxidative 8-oxoguanine lesion in human cells","volume":"60","author":"Le Page","year":"2000","journal-title":"Cancer Res"},{"key":"10.1016\/j.fertnstert.2008.12.052_bib8","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1038\/emm.2003.58","article-title":"Impaired phosphorylation and mis-localization of Bub1 and BubR1 are responsible for the defective mitotic checkpoint function in Brca2-mutant thymic lymphomas","volume":"35","author":"Lee","year":"2003","journal-title":"Exp Mol Med"},{"key":"10.1016\/j.fertnstert.2008.12.052_bib9","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1093\/hmg\/ddl002","article-title":"A role for Brca1 in chromosome end maintenance","volume":"15","author":"McPherson","year":"2006","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.fertnstert.2008.12.052_bib10","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/S1097-2765(00)80035-0","article-title":"Involvement of Brca2 in DNA repair","volume":"1","author":"Patel","year":"1998","journal-title":"Mol Cell"},{"key":"10.1016\/j.fertnstert.2008.12.052_bib11","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0092-8674(00)81847-4","article-title":"Association of BRCA1 with Rad51 in mitotic and meiotic cells","volume":"88","author":"Scully","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.fertnstert.2008.12.052_bib12","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1038\/35044000","article-title":"In search of the tumour-suppressor functions of BRCA1 and BRCA2","volume":"408","author":"Scully","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.fertnstert.2008.12.052_bib13","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.4161\/cc.3.11.1364","article-title":"Meiotic recombination: an affair of two recombinases","volume":"3","author":"Sehorn","year":"2004","journal-title":"Cell Cycle"},{"key":"10.1016\/j.fertnstert.2008.12.052_bib14","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1016\/j.cell.2007.02.025","article-title":"Further evidence for BRCA1 communication with the inactive X chromosome","volume":"128","author":"Silver","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.fertnstert.2008.12.052_bib15","doi-asserted-by":"crossref","first-page":"7900","DOI":"10.1038\/sj.onc.1203334","article-title":"BRCA1 deficient embryonic stem cells display a decreased homologous recombination frequency and an increased frequency of non-homologous recombination that is corrected by expression of a brca1 transgene","volume":"18","author":"Snouwaert","year":"1999","journal-title":"Oncogene"},{"key":"10.1016\/j.fertnstert.2008.12.052_bib16","first-page":"649","article-title":"BRCA1 mRNA is expressed highly during meiosis and spermiogenesis but not during mitosis of male germ cells","volume":"13","author":"Zabludoff","year":"1996","journal-title":"Oncogene"},{"key":"10.1016\/j.fertnstert.2008.12.052_bib17","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1093\/jncimonographs\/lgi012","article-title":"Reproductive issues for women with BRCA mutations","author":"Friedman","year":"2005","journal-title":"J Natl Cancer Inst Monogr"},{"key":"10.1016\/j.fertnstert.2008.12.052_bib18","doi-asserted-by":"crossref","first-page":"R15","DOI":"10.1186\/bcr1387","article-title":"Spontaneous and therapeutic abortions and the risk of breast cancer among BRCA mutation carriers","volume":"8","author":"Friedman","year":"2006","journal-title":"Breast Cancer Res"},{"key":"10.1016\/j.fertnstert.2008.12.052_bib19","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/35040500","article-title":"Telomere states and cell fates","volume":"408","author":"Blackburn","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.fertnstert.2008.12.052_bib20","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1097\/01.gco.0000193019.05686.49","article-title":"The telomere theory of reproductive senescence in women","volume":"18","author":"Keefe","year":"2006","journal-title":"Curr Opin Obstet Gynecol"},{"key":"10.1016\/j.fertnstert.2008.12.052_bib21","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1007\/BF00204931","article-title":"A test of the production line hypothesis of mammalian oogenesis","volume":"88","author":"Polani","year":"1991","journal-title":"Hum Genet"},{"key":"10.1016\/j.fertnstert.2008.12.052_bib22","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1002\/mrd.10041","article-title":"Oral antioxidants counteract the negative effects of female aging on oocyte quantity and quality in the mouse","volume":"61","author":"Tarin","year":"2002","journal-title":"Mol Reprod Dev"},{"key":"10.1016\/j.fertnstert.2008.12.052_bib23","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1093\/embo-reports\/kvf055","article-title":"Requirement of functional telomeres for metaphase chromosome alignments and integrity of meiotic spindles","volume":"3","author":"Liu","year":"2002","journal-title":"EMBO Rep"},{"key":"10.1016\/j.fertnstert.2008.12.052_bib24","doi-asserted-by":"crossref","first-page":"6496","DOI":"10.1073\/pnas.0400755101","article-title":"Irregular telomeres impair meiotic synapsis and recombination in mice","volume":"101","author":"Liu","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.fertnstert.2008.12.052_bib25","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1093\/molehr\/gag016","article-title":"Expression of apoptosis-related genes during human preimplantation embryo development: potential roles for the Harakiri gene product and Caspase-3 in blastomere fragmentation","volume":"9","author":"Jurisicova","year":"2003","journal-title":"Mol Hum Reprod"},{"key":"10.1016\/j.fertnstert.2008.12.052_bib26","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s00404-004-0690-2","article-title":"Is telomere length one of the determinants of reproductive life span?","volume":"272","author":"Aydos","year":"2005","journal-title":"Arch Gynecol Obstet"},{"key":"10.1016\/j.fertnstert.2008.12.052_bib27","doi-asserted-by":"crossref","first-page":"962","DOI":"10.4161\/cc.6.8.4105","article-title":"BRCA1 haploinsufficiency, but not heterozygosity for a BRCA1-truncating mutation, deregulates homologous recombination","volume":"6","author":"Cousineau","year":"2007","journal-title":"Cell Cycle"},{"key":"10.1016\/j.fertnstert.2008.12.052_bib28","doi-asserted-by":"crossref","first-page":"2510","DOI":"10.1245\/s10434-007-9372-1","article-title":"Heterogenic loss of the wild-type BRCA allele in human breast tumorigenesis","volume":"14","author":"King","year":"2007","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.fertnstert.2008.12.052_bib29","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/j.fertnstert.2005.02.037","article-title":"Upregulation of the BRCA1 gene in human germ cells and in preimplantation embryos","volume":"84","author":"Giscard d'Estaing","year":"2005","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2008.12.052_bib30","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.ydbio.2008.01.048","article-title":"Age-associated increase in aneuploidy and changes in gene expression in mouse eggs","volume":"316","author":"Pan","year":"2008","journal-title":"Dev Biol"},{"key":"10.1016\/j.fertnstert.2008.12.052_bib31","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1038\/35076590","article-title":"The emerging genetic and molecular basis of Fanconi anaemia","volume":"2","author":"Joenje","year":"2001","journal-title":"Nat Rev Genet"},{"key":"10.1016\/j.fertnstert.2008.12.052_bib32","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1093\/hmg\/ddg219","article-title":"Targeted disruption of exons 1 to 6 of the Fanconi Anemia group A gene leads to growth retardation, strain-specific microphthalmia, meiotic defects and primordial germ cell hypoplasia","volume":"12","author":"Wong","year":"2003","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.fertnstert.2008.12.052_bib33","doi-asserted-by":"crossref","first-page":"3226","DOI":"10.1182\/blood-2003-09-3138","article-title":"Germline mutations in BRCA2: shared genetic susceptibility to breast cancer, early onset leukemia, and Fanconi anemia","volume":"103","author":"Wagner","year":"2004","journal-title":"Blood"}],"container-title":["Fertility and Sterility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028208047936?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028208047936?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T07:40:58Z","timestamp":1758008458000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0015028208047936"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,4]]},"references-count":33,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2010,4]]}},"alternative-id":["S0015028208047936"],"URL":"https:\/\/doi.org\/10.1016\/j.fertnstert.2008.12.052","relation":{},"ISSN":["0015-0282"],"issn-type":[{"value":"0015-0282","type":"print"}],"subject":[],"published":{"date-parts":[[2010,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Fertility in women with BRCA mutations: a case-control study","name":"articletitle","label":"Article Title"},{"value":"Fertility and Sterility","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fertnstert.2008.12.052","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}